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学科主题: 基础医学
题名:
Electroacupuncture frequency-related transcriptional response in rat arcuate nucleus revealed region-distinctive changes in response to low- and high-frequency electroacupuncture
作者: Wang, Ke1,5; Zhang, Rong2,3,4; He, Fei5; Lin, Li-Bo5; Xiang, Xiao-Hui2,3,4; Ping, Xing-Jie2,3,4; Han, Ji-Sheng2,3,4; Zhao, Guo-Ping1,5; Zhang, Qing-Hua1,5; Cui, Cai-Lian2,3,4
关键词: electroacupuncture ; transcriptional profile ; arcuate nucleus
刊名: JOURNAL OF NEUROSCIENCE RESEARCH
发表日期: 2012-07-01
DOI: 10.1002/jnr.23028
卷: 90, 期:7, 页:1464-1473
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: ACUPUNCTURE ANALGESIA ; C-FOS ; NEURONS ; STIMULATION ; EXPRESSION ; GENES ; NORMALIZATION ; INFLAMMATION ; MECHANISMS ; SURVIVAL
英文摘要:

Electroacupuncture (EA) has been clinically applied for treating different medical conditions, such as pain, strain, and immune diseases. Low- and high-frequency EAs have distinct therapeutic effects in clinical practice and experimental studies. However, the molecular mechanism of this difference remains obscure. The arcuate nucleus (Arc) is a critical region of the hypothalamus and is responsible for the effect of EA stimulation to remote acupoints. Gene expression profiling provides a powerful tool with which to explore the basis of physiopathological responses to external stimulus. In this study, using cDNA microarray, we investigated gene expressions in the rat Arc region induced by low-frequency (2-Hz) and high-frequency (100-Hz) EAs to two remote acupoints, zusanli (ST36) and sanyinjiao (SP6). We have found that more genes were differentially regulated by 2-Hz EA than 100-Hz EA (154 vs. 66 regulated genes/ESTs) in Arc, especially those related to neurogenesis, which was confirmed by qRT-PCR. These results demonstrate that the expression level of genes in the Arc region could be effectively regulated by low-frequency EA, compared with high-frequency EA, helping to uncover the mechanisms of the therapeutic effects of the low-frequency EA. Our results also indicate different-frequency EAs are spatially specific. (c) 2012 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 973-2007CB512501 ; 20100480643
项目资助者: Chinese National Key Basic Research Project ; China Postdoctoral Science Foundation
WOS记录号: WOS:000303857400017
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63445
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Natl Engn Res Ctr Biochip Shanghai, Shanghai 201203, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
3.Peking Univ, Minist Publ Hlth, Beijing 100191, Peoples R China
4.Peking Univ, Dept Neurobiol, Hlth Sci Ctr, Key Lab Neurosci,Minist Educ, Beijing 100191, Peoples R China
5.Chinese Natl Human Genome Ctr Shanghai, Shanghai MOST Key Lab Hlth & Dis Genom, Shanghai 201203, Peoples R China

Recommended Citation:
Wang, Ke,Zhang, Rong,He, Fei,et al. Electroacupuncture frequency-related transcriptional response in rat arcuate nucleus revealed region-distinctive changes in response to low- and high-frequency electroacupuncture[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2012,90(7):1464-1473.
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