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ADME/Tox approach in inorganic medicinal chemistry
Yang, XD; Yang, XG
关键词inorganic pharmaceutics ADME/Tox pharmacokinetics pharmaceutical chemistry metal ions
刊名PROGRESS IN CHEMISTRY
2002-07-01
14期:4页:273-278
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]MOLECULAR MECHANISMS ; COPPER TRANSPORT ; IRON-METABOLISM ; DRUG DISCOVERY ; HEAVY-METALS ; TOXICITY ; ABSORPTION ; CACO-2 ; ALUMINUM ; MODEL
英文摘要

High throughput techniques and computer models are widely used in the absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) studies of drugs. Study of metal complexes and other inorganic compounds via the approach of ADME/Tox is a novel, active, and promising research area. The absorption, transport, cellular uptake, and metabolism of iron and copper currently received more attentions and some of the mechanisms were elucidated. The across membrane transportation of lanthanide ions was found to be through multiple pathways. Advances in the ADME/Tox research of other inorganic compounds were also reviewed.

语种中文
WOS记录号WOS:000178090100007
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63447
专题北京大学药学院_化学生物学系
作者单位Peking Univ, Natl Res Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yang, XD,Yang, XG. ADME/Tox approach in inorganic medicinal chemistry[J]. PROGRESS IN CHEMISTRY,2002,14(4):273-278.
APA Yang, XD,&Yang, XG.(2002).ADME/Tox approach in inorganic medicinal chemistry.PROGRESS IN CHEMISTRY,14(4),273-278.
MLA Yang, XD,et al."ADME/Tox approach in inorganic medicinal chemistry".PROGRESS IN CHEMISTRY 14.4(2002):273-278.
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