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学科主题: 药学
题名:
ADME/Tox approach in inorganic medicinal chemistry
作者: Yang, XD; Yang, XG
关键词: inorganic pharmaceutics ; ADME/Tox ; pharmacokinetics ; pharmaceutical chemistry ; metal ions
刊名: PROGRESS IN CHEMISTRY
发表日期: 2002-07-01
卷: 14, 期:4, 页:273-278
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: MOLECULAR MECHANISMS ; COPPER TRANSPORT ; IRON-METABOLISM ; DRUG DISCOVERY ; HEAVY-METALS ; TOXICITY ; ABSORPTION ; CACO-2 ; ALUMINUM ; MODEL
英文摘要:

High throughput techniques and computer models are widely used in the absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) studies of drugs. Study of metal complexes and other inorganic compounds via the approach of ADME/Tox is a novel, active, and promising research area. The absorption, transport, cellular uptake, and metabolism of iron and copper currently received more attentions and some of the mechanisms were elucidated. The across membrane transportation of lanthanide ions was found to be through multiple pathways. Advances in the ADME/Tox research of other inorganic compounds were also reviewed.

语种: 中文
WOS记录号: WOS:000178090100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63447
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: Peking Univ, Natl Res Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

Recommended Citation:
Yang, XD,Yang, XG. ADME/Tox approach in inorganic medicinal chemistry[J]. PROGRESS IN CHEMISTRY,2002,14(4):273-278.
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