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学科主题: 公共卫生
题名:
Genetic and environmental influences on blood pressure and body mass index in Han Chinese: a twin study
作者: Wu, Ting1,2; Snieder, Harold1,3; Li, Liming2; Cao, Weihua2; Zhan, Siyan2; Lv, Jun2; Gao, Wenjing2; Wang, Xiaoling3; Ding, Xiuhua3; Hu, Yonghua2
关键词: blood pressure ; heritability ; interaction ; obesity ; twin
刊名: HYPERTENSION RESEARCH
发表日期: 2011-02-01
DOI: 10.1038/hr.2010.194
卷: 34, 期:2, 页:173-179
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: GENOME-WIDE ASSOCIATION ; RISK-FACTORS ; SOCIOECONOMIC-STATUS ; WAIST CIRCUMFERENCE ; COMPLEX DISEASES ; SERUM-LIPIDS ; ADULT TWINS ; HYPERTENSION ; OBESITY ; WEIGHT
英文摘要:

The familial aggregation of blood pressure (BP) may be partly due to the familial aggregation of obesity, caused by genetic and/or environmental factors that influence both. Gene-obesity interactions are expected to result in different heritability estimates for BP at different obesity levels. However, the latter hypothesis has never been tested. The present study included 1243 monozygotic and 833 dizygotic Han Chinese twins (mean +/- s.d. age: 37.81 +/- 9.82; range: 19.1-81.4) from the Chinese National Twin Registry. Body mass index (BMI) was used as the index of general obesity. The outcome measures were systolic BP (SBP) and diastolic BP (DBP). Quantitative genetic modeling was performed using Mx software. The SBP and DBP heritabilities were 46 and 30%, respectively. The positive correlations of BMI with SBP (r=0.26) and with DBP (r=0.27) were largely due to genetic factors (approximately 85%). Genetic factors, which also influence BMI, account for 6 and 7% of the total variance for SBP and DBP, respectively. The gene-obesity interaction analysis showed that both common and unique environmental influences on SBP increased with increasing levels of BMI, resulting in a lower heritability at higher BMI levels, whereas for DBP the heritability remained unchanged at higher BMI levels. Our results suggest that higher BMIs may reduce SBP heritability through a larger impact of environmental effects. These conclusions may be valuable for gene-finding studies. Hypertension Research (2011) 34, 173-179; doi: 10.1038/hr.2010.194; published online 4 November 2010

语种: 英语
所属项目编号: 01-746 ; 30070672
项目资助者: China Medical Board of New York ; National Natural Science Foundation of China
WOS记录号: WOS:000287020000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63448
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Univ Groningen, Univ Med Ctr Groningen, Unit Genet Epidemiol & Bioinformat, Dept Epidemiol, NL-9700 RB Groningen, Netherlands
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100083, Peoples R China
3.Med Coll Georgia, Georgia Prevent Inst, Dept Pediat, Augusta, GA 30912 USA

Recommended Citation:
Wu, Ting,Snieder, Harold,Li, Liming,et al. Genetic and environmental influences on blood pressure and body mass index in Han Chinese: a twin study[J]. HYPERTENSION RESEARCH,2011,34(2):173-179.
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