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Genetic and environmental influences on blood pressure and body mass index in Han Chinese: a twin study
Wu, Ting1,2; Snieder, Harold1,3; Li, Liming2; Cao, Weihua2; Zhan, Siyan2; Lv, Jun2; Gao, Wenjing2; Wang, Xiaoling3; Ding, Xiuhua3; Hu, Yonghua2
关键词blood pressure heritability interaction obesity twin
刊名HYPERTENSION RESEARCH
2011-02-01
DOI10.1038/hr.2010.194
34期:2页:173-179
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]GENOME-WIDE ASSOCIATION ; RISK-FACTORS ; SOCIOECONOMIC-STATUS ; WAIST CIRCUMFERENCE ; COMPLEX DISEASES ; SERUM-LIPIDS ; ADULT TWINS ; HYPERTENSION ; OBESITY ; WEIGHT
英文摘要

The familial aggregation of blood pressure (BP) may be partly due to the familial aggregation of obesity, caused by genetic and/or environmental factors that influence both. Gene-obesity interactions are expected to result in different heritability estimates for BP at different obesity levels. However, the latter hypothesis has never been tested. The present study included 1243 monozygotic and 833 dizygotic Han Chinese twins (mean +/- s.d. age: 37.81 +/- 9.82; range: 19.1-81.4) from the Chinese National Twin Registry. Body mass index (BMI) was used as the index of general obesity. The outcome measures were systolic BP (SBP) and diastolic BP (DBP). Quantitative genetic modeling was performed using Mx software. The SBP and DBP heritabilities were 46 and 30%, respectively. The positive correlations of BMI with SBP (r=0.26) and with DBP (r=0.27) were largely due to genetic factors (approximately 85%). Genetic factors, which also influence BMI, account for 6 and 7% of the total variance for SBP and DBP, respectively. The gene-obesity interaction analysis showed that both common and unique environmental influences on SBP increased with increasing levels of BMI, resulting in a lower heritability at higher BMI levels, whereas for DBP the heritability remained unchanged at higher BMI levels. Our results suggest that higher BMIs may reduce SBP heritability through a larger impact of environmental effects. These conclusions may be valuable for gene-finding studies. Hypertension Research (2011) 34, 173-179; doi: 10.1038/hr.2010.194; published online 4 November 2010

语种英语
WOS记录号WOS:000287020000007
项目编号01-746 ; 30070672
资助机构China Medical Board of New York ; National Natural Science Foundation of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63448
专题北京大学公共卫生学院
北京大学公共卫生学院_公共卫生学院
北京大学临床肿瘤学院_麻醉科
作者单位1.Univ Groningen, Univ Med Ctr Groningen, Unit Genet Epidemiol & Bioinformat, Dept Epidemiol, NL-9700 RB Groningen, Netherlands
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100083, Peoples R China
3.Med Coll Georgia, Georgia Prevent Inst, Dept Pediat, Augusta, GA 30912 USA
推荐引用方式
GB/T 7714
Wu, Ting,Snieder, Harold,Li, Liming,et al. Genetic and environmental influences on blood pressure and body mass index in Han Chinese: a twin study[J]. HYPERTENSION RESEARCH,2011,34(2):173-179.
APA Wu, Ting.,Snieder, Harold.,Li, Liming.,Cao, Weihua.,Zhan, Siyan.,...&Hu, Yonghua.(2011).Genetic and environmental influences on blood pressure and body mass index in Han Chinese: a twin study.HYPERTENSION RESEARCH,34(2),173-179.
MLA Wu, Ting,et al."Genetic and environmental influences on blood pressure and body mass index in Han Chinese: a twin study".HYPERTENSION RESEARCH 34.2(2011):173-179.
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