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学科主题: 基础医学
题名:
HPtaa database-potential target genes for clinical diagnosis and immunotherapy of human carcinoma
作者: Wang, Xiaosong; Zhao, Haitao; Xu, Qingwen; Jin, Weibo; Liu, Changning; Zhang, Huagang; Huang, Zhibin; Zhang, Xinyu; Zhang, Yu; Xin, Dianqi; Simpson, Andrew J. G.; Old, Lloyd J.; Na, Yanqun; Zhao, Yi; Chen, Weifeng
刊名: NUCLEIC ACIDS RESEARCH
发表日期: 2006
DOI: 10.1093/nar/gkj082
卷: 34, 期:SI, 页:D607-D612
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: EXPRESSION PATTERNS ; PROSTATE-CANCER ; ADENOCARCINOMA ; PROTEIN ; TRANSCRIPTOMES ; IDENTIFICATION ; PROFILES ; RESOURCE ; ANTIGENS ; ANTIBODY
英文摘要:

Tumor-associated antigens (TAAs) have been the most actively employed targets in the clinical diagnosis and treatment of human carcinoma, such as PSA in the diagnosis of prostate cancer and NY-ESO-1 in the immunotherapy of melanoma and other cancers. However, identification of TAAs has often been hampered by the complicated and laborsome laboratory procedures. In order to accelerate the process of tumor antigen discovery, and thereby improve diagnosis and treatment of human carcinoma, we have made an effort to establish a publicly available Human Potential Tumor Associated Antigen database (HPtaa) with potential TAAs identified by in silico computing (http://www.hptaa.org). Tumor specificity was chosen as the core of tumor antigen evaluation, together with other relevant clues. Various platforms of gene expression, including microarray, expressed sequence tag and SAGE data, were processed and integrated by several penalty algorithms. A total of 3518 potential TAAs have been included in the database, which is freely available to academic users. As far as we know, this database is the first one addressing human potential TAAs, and the first one integrating various kinds of expression platforms for one purpose.

语种: 英语
WOS记录号: WOS:000239307700129
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63450
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Immunol, Beijing 100083, Peoples R China
2.Inst Comp Technol, Bioinformat Res Grp, Key Lab Intelligent Informat Proc, Beijing 100080, Peoples R China
3.Peking Univ, Inst Urol, Dept Urol, Hosp Peking Univ 1, Beijing 100034, Peoples R China
4.Chinese Acad Med Sci, Dept Gen Surg, Peking Union Med Coll Hosp, Beijing 100032, Peoples R China
5.Mem Sloan Kettering Canc Ctr, Ludwig Inst Canc Res, New York Branch, New York, NY 10021 USA
6.Tsinghua Univ, Dept Biol Sci & Biotechnol, Minist Educ Key Lab Bioinformat, Beijing 100084, Peoples R China

Recommended Citation:
Wang, Xiaosong,Zhao, Haitao,Xu, Qingwen,et al. HPtaa database-potential target genes for clinical diagnosis and immunotherapy of human carcinoma[J]. NUCLEIC ACIDS RESEARCH,2006,34(SI):D607-D612.
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