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学科主题: 基础医学
题名:
Effect of A beta(1-40) on membrane permeability and intracellular free Ca2+ of nerve cells
作者: Ma, XC; Sha, YL; Lin, KC; Nie, SQ
关键词: soluble and fibrillar A beta(1-40) ; membrane permeability ; intracellular calcium
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2003-05-01
DOI: 10.1360/02wc0343
卷: 48, 期:10, 页:974-978
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ALZHEIMERS-DISEASE ; AMYLOID PROTEIN ; CALCIUM ; RECEPTOR
英文摘要:

The effects of soluble and fibrillar Abeta(1-40) on membrane permeability and intracellular free Ca2+ of nerve cells were investigated by the laser confocal microscopy. Results indicate that: i) Effects of soluble and fibrillar Abeta(1-40) on cell membrane permeability are both concentration-dependent. Soluble Abeta(1-40) increases membrane permeability only at concentration of 3 mumol/L, while the toxic effect of fibrillar Abeta(1-40) is much stronger, its evident effect begins from 1 mumol/L. When its concentration rose to 3 mumol/L, not only the membrane permeability increased, but also the nuclear membrane broke seriously. ii) Both soluble and fibrillar Abeta(1-40) at high concentrations increased the intracellular free Ca2+, and the increased amplitudes are concentration-dependent. However, the fibrillar one induces the increase of intracellular Ca2+ much quicker and synchronously. These results indicate that some correlation exists between the neurotoxicity of high concentration soluble and fibrillar Abeta(1-40) and the change of physico-chemical properties and intracellular Ca ion imbalance.

语种: 英语
WOS记录号: WOS:000183349600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63452
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100083, Peoples R China

Recommended Citation:
Ma, XC,Sha, YL,Lin, KC,et al. Effect of A beta(1-40) on membrane permeability and intracellular free Ca2+ of nerve cells[J]. CHINESE SCIENCE BULLETIN,2003,48(10):974-978.
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