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Effect of A beta(1-40) on membrane permeability and intracellular free Ca2+ of nerve cells
Ma, XC; Sha, YL; Lin, KC; Nie, SQ
关键词soluble and fibrillar A beta(1-40) membrane permeability intracellular calcium
刊名CHINESE SCIENCE BULLETIN
2003-05-01
DOI10.1360/02wc0343
48期:10页:974-978
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ALZHEIMERS-DISEASE ; AMYLOID PROTEIN ; CALCIUM ; RECEPTOR
英文摘要

The effects of soluble and fibrillar Abeta(1-40) on membrane permeability and intracellular free Ca2+ of nerve cells were investigated by the laser confocal microscopy. Results indicate that: i) Effects of soluble and fibrillar Abeta(1-40) on cell membrane permeability are both concentration-dependent. Soluble Abeta(1-40) increases membrane permeability only at concentration of 3 mumol/L, while the toxic effect of fibrillar Abeta(1-40) is much stronger, its evident effect begins from 1 mumol/L. When its concentration rose to 3 mumol/L, not only the membrane permeability increased, but also the nuclear membrane broke seriously. ii) Both soluble and fibrillar Abeta(1-40) at high concentrations increased the intracellular free Ca2+, and the increased amplitudes are concentration-dependent. However, the fibrillar one induces the increase of intracellular Ca2+ much quicker and synchronously. These results indicate that some correlation exists between the neurotoxicity of high concentration soluble and fibrillar Abeta(1-40) and the change of physico-chemical properties and intracellular Ca ion imbalance.

语种英语
WOS记录号WOS:000183349600008
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63452
专题基础医学院_生物物理学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100083, Peoples R China
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GB/T 7714
Ma, XC,Sha, YL,Lin, KC,et al. Effect of A beta(1-40) on membrane permeability and intracellular free Ca2+ of nerve cells[J]. CHINESE SCIENCE BULLETIN,2003,48(10):974-978.
APA Ma, XC,Sha, YL,Lin, KC,&Nie, SQ.(2003).Effect of A beta(1-40) on membrane permeability and intracellular free Ca2+ of nerve cells.CHINESE SCIENCE BULLETIN,48(10),974-978.
MLA Ma, XC,et al."Effect of A beta(1-40) on membrane permeability and intracellular free Ca2+ of nerve cells".CHINESE SCIENCE BULLETIN 48.10(2003):974-978.
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