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学科主题: 临床医学
题名:
Dosimetric comparison between jaw tracking and static jaw techniques in intensity-modulated radiotherapy
作者: Feng, Zhongsu1; Wu, Hao2; Zhang, Yibao2; Zhang, Yunjun3; Cheng, Jinsheng1; Su, Xu1
关键词: Jaw tracking ; IMRT ; Dosimetry ; OARs sparing
刊名: RADIATION ONCOLOGY
发表日期: 2015-01-27
DOI: 10.1186/s13014-015-0329-4
卷: 10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: LUNG-CANCER NSCLC ; FILTER-FREE BEAMS ; CONFORMAL RADIOTHERAPY ; RADIATION PNEUMONITIS ; ESOPHAGEAL CANCER ; IMRT ; FEASIBILITY ; THERAPY ; SYSTEM
英文摘要:

Purpose: To compare the dosimetric differences between jaw tracking technique (JTT) and static jaw technique (SJT) in dynamic intensity-modulated radiotherapy (d-IMRT) and assess the potential advantages of jaw tracking technique.

Methods: Two techniques, jaw tracking and static jaw, were used respectively to develop the d-IMRT plans for 28 cancer patients with various lesion sites: head and neck, lungs, esophageal, abdominal, prostate, rectal and cervical. The dose volume histograms (DVH) and selected dosimetric indexes for the whole body and for organs at risk (OARs) were compared. A two dimensional ionization chamber Array Seven29 (PTW, Freiburg, Germany) and OCTAVIUS Octagonal phantom (PTW, Freiburg, Germany) were used to verify all the plans.

Results: For all patients, the treatment plans using both techniques met the clinical requirements. The V-5, V-10, V-20, V-30, V-40 (volumes receiving 5, 10, 20, 30 and 40 Gy at least, respectively), mean dose (D-mean) for the whole body and V-5, V-10, V-20, Dmean for lungs in the JTT d-IMRT plans were significantly less than the corresponding values of the SJT d-IMRT plans (p < 0.001). The JTT d-IMRT plans deposited lower maximum dose (D-max) to the lens, eyes, brainstem, spinal cord, and right optic nerve, the doses reductions for these OARs ranged from 2.2% to 28.6%. The JTT d-IMRT plans deposited significantly lower D-mean to various OARs (all p values < 0.05), the mean doses reductions for these OARs ranged from 1.1% to 31.0%, and the value reductions depend on the volume and the location of the OARs. The gamma evaluation method showed an excellent agreement between calculation and measurement for all techniques with criteria of 3%/3 mm.

Conclusions: Both jaw tracking and static jaw d-IMRT plans can achieve comparable target dose coverage. JTT displays superior OARs sparing than SJT plans. These results are of clinical importance, especially for the patients with large and complex targets but close to some highly radio-sensitive organs to spare, and for patients with local recurrent or secondary primary malignant lesion within a previously irradiated area.

语种: 英语
所属项目编号: 201002009
项目资助者: National Health and Family Planning Commission of China
WOS记录号: WOS:000349283700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63458
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Chinese Ctr Dis Control & Prevent, Chinese Ctr Med Response Radiat Emergency, Natl Inst Radiol Protect, Beijing 100088, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Radiotherapy, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Fdn Educ, Beijing 100191, Peoples R China

Recommended Citation:
Feng, Zhongsu,Wu, Hao,Zhang, Yibao,et al. Dosimetric comparison between jaw tracking and static jaw techniques in intensity-modulated radiotherapy[J]. RADIATION ONCOLOGY,2015,10.
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