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学科主题基础医学
LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma
Yang, Yu2; Yang, Hua1; McNutt, Michael A.2; Xiong, Fuxia1; Nie, Xiu3; Li, Li4; Zhou, Rouli1
关键词lysosome-associated protein transmembrane 4 beta immunohistochemistry ovarian carcinoma survival
刊名ONCOLOGY REPORTS
2008-11-01
DOI10.3892/or_00000112
20期:5页:1077-1083
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; EXPRESSION ; CANCER ; TUMORS
英文摘要

Lysosome-associated protein transmembrane 4 beta (LAPTM4B) is a member of the mammalian 4-tetratransmembrane spanning protein superfamily, which is strongly expressed in some solid malignancies. The present study investigated the correlation of LAPTM4B expression with clinicopathological features and prognosis in ovarian carcinoma. Expression of LAPTM4B was evaluated semiquantitatively by immunohistochemistry in 85 cases of ovarian carcinoma. High LAPTM4B expression was found in 54 (63.5%) of these 85 carcinomas, and was positively correlated with FIGO stage, histological subtype and residual tumor after primary surgery, but not with age and tumor grade. Patients with high LAPTM4B expression had significantly poorer overall survival (OS) and progression-free survival (PFS) (P < 0.001 and P < 0.001, respectively) compared to patients with low expression of LAPTM4B. On multivariate analysis, LAPTM4B expression was found to be an independent prognostic factor for OS and PFS (P=0.01 and P=0.03, respectively). These results showed that high LAPTM4B expression was associated with progression of ovarian carcinoma and correlated with unfavorable clinical outcome, suggesting that LAPTM4B may be a clinically useful prognostic indicator for ovarian carcinoma.

语种英语
WOS记录号WOS:000260648200012
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被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63459
专题基础医学院_细胞生物学系
作者单位1.Peking Univ, Ctr Hlth Sci, Dept Cell Biol, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Dept Pathol, Beijing 100083, Peoples R China
3.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pathol, Wuhan 430022, Peoples R China
4.Peking Univ, Dept Obstet & Gynecol, Beijing 100083, Peoples R China
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Yang, Yu,Yang, Hua,McNutt, Michael A.,et al. LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma[J]. ONCOLOGY REPORTS,2008,20(5):1077-1083.
APA Yang, Yu.,Yang, Hua.,McNutt, Michael A..,Xiong, Fuxia.,Nie, Xiu.,...&Zhou, Rouli.(2008).LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma.ONCOLOGY REPORTS,20(5),1077-1083.
MLA Yang, Yu,et al."LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma".ONCOLOGY REPORTS 20.5(2008):1077-1083.
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