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学科主题: 基础医学
题名:
LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma
作者: Yang, Yu2; Yang, Hua1; McNutt, Michael A.2; Xiong, Fuxia1; Nie, Xiu3; Li, Li4; Zhou, Rouli1
关键词: lysosome-associated protein transmembrane 4 beta ; immunohistochemistry ; ovarian carcinoma ; survival
刊名: ONCOLOGY REPORTS
发表日期: 2008-11-01
DOI: 10.3892/or_00000112
卷: 20, 期:5, 页:1077-1083
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; EXPRESSION ; CANCER ; TUMORS
英文摘要:

Lysosome-associated protein transmembrane 4 beta (LAPTM4B) is a member of the mammalian 4-tetratransmembrane spanning protein superfamily, which is strongly expressed in some solid malignancies. The present study investigated the correlation of LAPTM4B expression with clinicopathological features and prognosis in ovarian carcinoma. Expression of LAPTM4B was evaluated semiquantitatively by immunohistochemistry in 85 cases of ovarian carcinoma. High LAPTM4B expression was found in 54 (63.5%) of these 85 carcinomas, and was positively correlated with FIGO stage, histological subtype and residual tumor after primary surgery, but not with age and tumor grade. Patients with high LAPTM4B expression had significantly poorer overall survival (OS) and progression-free survival (PFS) (P < 0.001 and P < 0.001, respectively) compared to patients with low expression of LAPTM4B. On multivariate analysis, LAPTM4B expression was found to be an independent prognostic factor for OS and PFS (P=0.01 and P=0.03, respectively). These results showed that high LAPTM4B expression was associated with progression of ovarian carcinoma and correlated with unfavorable clinical outcome, suggesting that LAPTM4B may be a clinically useful prognostic indicator for ovarian carcinoma.

语种: 英语
WOS记录号: WOS:000260648200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63459
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Peking Univ, Ctr Hlth Sci, Dept Cell Biol, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Dept Pathol, Beijing 100083, Peoples R China
3.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pathol, Wuhan 430022, Peoples R China
4.Peking Univ, Dept Obstet & Gynecol, Beijing 100083, Peoples R China

Recommended Citation:
Yang, Yu,Yang, Hua,McNutt, Michael A.,et al. LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma[J]. ONCOLOGY REPORTS,2008,20(5):1077-1083.
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