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Association between PADI4 gene polymorphisms and anti-cyclic citrullinated peptide antibody positive rheumatoid arthritis in a large Chinese Han cohort
Du, Y.1; Liu, X.1; Guo, J. P.1; Liu, X.2; Li, R.1; Zhao, Y.3; Liu, X.4; Li, M. H.1; Li, Z. G.1
关键词rheumatoid arthritis peptidyl-arginine-deiminase type IV single nucleotide polymorphism anti-cyclic citrullinated peptide antibody bone destruction
刊名CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
2014-05-01
32期:3页:377-382
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
资助者National Basic Research Program of China (973 program) ; MOST ; NSFC ; National Natural Science Foundation of China (NSFC) ; Chinese Medical Association ; Beijing Natural Science Foundation ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ; National Basic Research Program of China (973 program) ; MOST ; NSFC ; National Natural Science Foundation of China (NSFC) ; Chinese Medical Association ; Beijing Natural Science Foundation ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
研究领域[WOS]Rheumatology
关键词[WOS]PEPTIDYLARGININE DEIMINASE TYPE-4 ; SHARED EPITOPE ALLELES ; FUNCTIONAL HAPLOTYPE ; JAPANESE POPULATION ; METAANALYSIS ; GENOTYPE
英文摘要

Objective

The present study was undertaken to investigate the association of peptidyl-arginine-deiminase type IV gene (PADI4) single nucleotide polymorphisms (SNPs) with rheumatoid arthritis (RA) susceptibility, and to determine whether there is any impact of PADI4 polymorphisms on RA subsets or phenotypes in a large Chinese Han cohort.

Methods

Two PADI4 SNPs (rs2240340 and rs1748033) were genotyped in 1216 Chinese Han RA patients and 1040 unaffected controls by TaqMan SNP Assays. Serum anti-CCP antibody and anti-PAD4 antibody levels were measured by ELISA. Bone destruction was scored by Sharp-van der Heijde scores (SHSs) of hands in 463 patients.

Results

The two SNPs rs2240340 and rs1748033 of PADI4 showed strong association with RA susceptibility (OR=1.23, 95% CI 1.09-1.38, p=6.66x10(-4); and OR=1.24, 95% CI 1.10-1.41, p=6.98x10(-4), respectively). RA risk genotypes of PADI4 were specifically associated with anti-CCP positive RA (rs2240340: 19=5.13x10(-6); rs1748033: p=2.97x10(-3), respectively). Furthermore, there was a trend association between PADI4 rs2240340 and radiographic severity, though it did not reach statistical significance (p=0.088).

Conclusion

Our data provide strong evidence that PADI4 polymorphisms are risk factors contributed to RA susceptibility, especially for anti-CCP positive RA, and may confer higher risk of RA radiographic severity in Chinese Han population.

语种英语
所属项目编号2010CB529104 ; 2010DFB34000 ; 81120108020 ; 30901319 ; 31270914 ; 12040660366 ; 7122196 ; JWSL431
资助者National Basic Research Program of China (973 program) ; MOST ; NSFC ; National Natural Science Foundation of China (NSFC) ; Chinese Medical Association ; Beijing Natural Science Foundation ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ; National Basic Research Program of China (973 program) ; MOST ; NSFC ; National Natural Science Foundation of China (NSFC) ; Chinese Medical Association ; Beijing Natural Science Foundation ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
WOS记录号WOS:000337662900011
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63461
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Radiol, Beijing 100044, Peoples R China
3.Capital Med Univ, Xuanwu Hosp, Dept Rheumatol, Beijing, Peoples R China
4.China Japan Friendship Hosp, Dept Rheumatol, Beijing, Peoples R China
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GB/T 7714
Du, Y.,Liu, X.,Guo, J. P.,et al. Association between PADI4 gene polymorphisms and anti-cyclic citrullinated peptide antibody positive rheumatoid arthritis in a large Chinese Han cohort[J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,2014,32(3):377-382.
APA Du, Y..,Liu, X..,Guo, J. P..,Liu, X..,Li, R..,...&Li, Z. G..(2014).Association between PADI4 gene polymorphisms and anti-cyclic citrullinated peptide antibody positive rheumatoid arthritis in a large Chinese Han cohort.CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,32(3),377-382.
MLA Du, Y.,et al."Association between PADI4 gene polymorphisms and anti-cyclic citrullinated peptide antibody positive rheumatoid arthritis in a large Chinese Han cohort".CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 32.3(2014):377-382.
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