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IR@PKUHSC  > 北京大学药学院  > 药剂学系  > 期刊论文
学科主题: 药学
题名:
An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets
作者: Fan, TY; Wei, SL; Yan, WW; Chen, DB; Li, J
关键词: pulsatile release tablets ; diltiazem hydrochloride ; lag time ; bioavailability ; film coating
刊名: JOURNAL OF CONTROLLED RELEASE
发表日期: 2001-12-13
卷: 77, 期:3, 页:245-251
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: DRUG-DELIVERY SYSTEM ; DESIGN ; MATRIX ; HYDROXYETHYLCELLULOSE ; ABSORPTION ; DOGS ; TES
英文摘要:

To develop new pulsatile release tablets, which can suppress drug release in stomach and release the drug rapidly after a predetermined lag time of about 3 h in intestine, the use of tablets with ethylcellulose/Eudragit L as a coating film and cross-linked poly vinylpyrrolidone in the core tablets was investigated. The release of diltiazem hydrochloride (DIL) as a model drug in the core tablets was investigated in vitro. The lag time (t(10)) was prolonged with an increase of the coating level, whereas the drug release rate was almost constant, irrespective of the coating level. The water-uptake study and electron microscope photographs suggested the mechanism of pulsatile release of drug. Pulsatile release tablets containing 60 mg DIL with 4.4 h of lag time (t(10)) in vitro were administrated to eight volunteers. The mean plasma concentration curves showed 4.9 h of lag time (t(lag)), 8.0 h of time to maximum concentration (t(max)) and 3.1 h of time between t(max) and t(lag) (t(pst)) in vivo. Relative bioavailability was 1.05 for pulsatile release tablets compared to conventional tablets. (C) 2001 Published by Elsevier Science B.V.

语种: 英语
WOS记录号: WOS:000173326300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63464
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Pharm, Beijing 100083, Peoples R China

Recommended Citation:
Fan, TY,Wei, SL,Yan, WW,et al. An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets[J]. JOURNAL OF CONTROLLED RELEASE,2001,77(3):245-251.
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