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An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets
Fan, TY; Wei, SL; Yan, WW; Chen, DB; Li, J
关键词pulsatile release tablets diltiazem hydrochloride lag time bioavailability film coating
刊名JOURNAL OF CONTROLLED RELEASE
2001-12-13
77期:3页:245-251
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]DRUG-DELIVERY SYSTEM ; DESIGN ; MATRIX ; HYDROXYETHYLCELLULOSE ; ABSORPTION ; DOGS ; TES
英文摘要

To develop new pulsatile release tablets, which can suppress drug release in stomach and release the drug rapidly after a predetermined lag time of about 3 h in intestine, the use of tablets with ethylcellulose/Eudragit L as a coating film and cross-linked poly vinylpyrrolidone in the core tablets was investigated. The release of diltiazem hydrochloride (DIL) as a model drug in the core tablets was investigated in vitro. The lag time (t(10)) was prolonged with an increase of the coating level, whereas the drug release rate was almost constant, irrespective of the coating level. The water-uptake study and electron microscope photographs suggested the mechanism of pulsatile release of drug. Pulsatile release tablets containing 60 mg DIL with 4.4 h of lag time (t(10)) in vitro were administrated to eight volunteers. The mean plasma concentration curves showed 4.9 h of lag time (t(lag)), 8.0 h of time to maximum concentration (t(max)) and 3.1 h of time between t(max) and t(lag) (t(pst)) in vivo. Relative bioavailability was 1.05 for pulsatile release tablets compared to conventional tablets. (C) 2001 Published by Elsevier Science B.V.

语种英语
WOS记录号WOS:000173326300008
引用统计
被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63464
专题北京大学药学院_药剂学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Pharm, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Fan, TY,Wei, SL,Yan, WW,et al. An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets[J]. JOURNAL OF CONTROLLED RELEASE,2001,77(3):245-251.
APA Fan, TY,Wei, SL,Yan, WW,Chen, DB,&Li, J.(2001).An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets.JOURNAL OF CONTROLLED RELEASE,77(3),245-251.
MLA Fan, TY,et al."An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets".JOURNAL OF CONTROLLED RELEASE 77.3(2001):245-251.
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