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学科主题: 基础医学
题名:
Observation of mesenteric microcirculatory disturbance in rat by laser oblique scanning optical microscopy
作者: Ding, Yichen1; Zhang, Yu2; Peng, Tong1; Lu, Yiqing4; Jin, Dayong4; Ren, Qiushi1; Liu, Yuying2; Han, Jingyan2,3; Xi, Peng1
刊名: SCIENTIFIC REPORTS
发表日期: 2013-05-03
DOI: 10.1038/srep01762
卷: 3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ISCHEMIA-REPERFUSION ; LEUKOCYTE ADHESION ; LACTIC-ACID ; IN-VIVO ; ISCHEMIA/REPERFUSION ; INFLAMMATION ; RESPONSES ; INJURY
英文摘要:

Ischemia-reperfusion (I/R) injury model has been widely applied to the study of microcirculation disturbance. In this work, we used laser oblique scanning optical microscopy (LOSOM) to observe the microcirculation system in the mesentery of rat model. Utilizing a localized point-scanning detection scheme, high-contrast images of leukocytes were obtained. The extended detection capability facilitated both the automatic in vivo cell counting and the accurate measurement of the rolling velocity of leukocytes. Statistical analysis of the different treatment groups suggested that the distinction between I/R and sham groups with time lapse is significant.

语种: 英语
所属项目编号: 2011CB809101 ; 2010CB933901 ; 2011CB707502 ; 61178076 ; 81072909 ; BMU20100114
项目资助者: "973" Major State Basic Research Development Program of China ; National Natural Science Foundation of China ; PKU Med-Engineering seed grant
WOS记录号: WOS:000318333900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63465
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
4.Macquarie Univ, MQphoton Res Ctr, Adv Cytometry Labs, Sydney, NSW 2109, Australia

Recommended Citation:
Ding, Yichen,Zhang, Yu,Peng, Tong,et al. Observation of mesenteric microcirculatory disturbance in rat by laser oblique scanning optical microscopy[J]. SCIENTIFIC REPORTS,2013,3.
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