IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Daily protein intake and survival in patients on peritoneal dialysis
Dong, Jie1,2,3; Li, Yanjun1,2,3; Xu, Ying; Xu, Rong1,2,3
关键词cardiovascular dietary energy nutrition peritoneal dialysis protein
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2011-11-01
DOI10.1093/ndt/gfr142
26期:11页:3715-3721
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
研究领域[WOS]Transplantation ; Urology & Nephrology
关键词[WOS]CHRONIC-RENAL-FAILURE ; INTRADIALYTIC PARENTERAL-NUTRITION ; CLINICAL-PRACTICE GUIDELINES ; CHRONIC KIDNEY-DISEASE ; LEAN BODY-MASS ; HEMODIALYSIS-PATIENTS ; TRANSPORT CHARACTERISTICS ; NITROGEN APPEARANCE ; DOQI GUIDELINES ; ESRD PATIENTS
英文摘要

Background. The decreased protein intake may lead to protein-energy wasting and poor survival. It is unknown what the appropriate protein intake in patients on peritoneal dialysis (PD) is. We aimed to explore the appropriate levels of daily protein intake (DPI) in favor of outcome in a large PD cohort.

Methods. Our study enrolled 305 incident patients, who could be followed regularly. Demographic data were collected at baseline. Biochemical, dietary and nutritional data and dialysis adequacy were measured at the baseline and thereafter at regular intervals. Outcome events included all-cause death, cardiovascular disease (CVD) death and first-episode peritonitis.

Results. A total of 127 patients died during the 44.5-month follow-up, 41.7% of whom died from CVD. A total of 129 cases first-episode peritonitis were observed. Patients with a high tertile of baseline DPI (>= 0.94 g/kg/day) had significantly higher serum albumin, prealbumin, hemoglobin, lean body mass and handgrip strength compared to the low tertile group (<= 0.73 g/kg/day) (P < 0.05-0.001). They also had significantly lower risk for all-cause, CVD death and first-episode peritonitis than the low tertile group adjusted for commonly recognized confounders. Although patients in the middle tertile of DPI (0.74-0.93 g/kg/day) did not show significant differences in the majority of nutritional markers, all-cause and CVD mortality compared to high tertile group, they had a trend to a negative nitrogen balance and similar risk for first-episode peritonitis to the low tertile group. The DPI included as a time-dependent variable could not predict any outcome events in multivariate Cox models.

Conclusions. Our study revealed that DPI < 0.73 g/kg/day was associated with protein-energy wasting and worst outcome for PD patients. The DPI > 0.94 g/kg/day was in favor of nutrition status and long-term outcome in this population.

语种英语
WOS记录号WOS:000296350400046
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63467
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Dept Med, Renal Div, Beijing 100871, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Dong, Jie,Li, Yanjun,Xu, Ying,et al. Daily protein intake and survival in patients on peritoneal dialysis[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2011,26(11):3715-3721.
APA Dong, Jie,Li, Yanjun,Xu, Ying,&Xu, Rong.(2011).Daily protein intake and survival in patients on peritoneal dialysis.NEPHROLOGY DIALYSIS TRANSPLANTATION,26(11),3715-3721.
MLA Dong, Jie,et al."Daily protein intake and survival in patients on peritoneal dialysis".NEPHROLOGY DIALYSIS TRANSPLANTATION 26.11(2011):3715-3721.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Dong, Jie]的文章
[Li, Yanjun]的文章
[Xu, Ying]的文章
百度学术
百度学术中相似的文章
[Dong, Jie]的文章
[Li, Yanjun]的文章
[Xu, Ying]的文章
必应学术
必应学术中相似的文章
[Dong, Jie]的文章
[Li, Yanjun]的文章
[Xu, Ying]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。