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学科主题: 临床医学
题名:
Selective Head Cooling with Mild Systemic Hypothermia after Neonatal Hypoxic-Ischemic Encephalopathy: A Multicenter Randomized Controlled Trial in China
作者: Zhou, Wen-hao1; Cheng, Guo-qiang1; Shao, Xiao-mei1; Liu, Xian-zhi; Shan, Ruo-bing; Zhuang, De-yi; Zhou, Cong-le2; Du, Li-zhong3; Cao, Yun1; Yang, Qun1; Wang, Lai-shuan1; China Study Grp
刊名: JOURNAL OF PEDIATRICS
发表日期: 2010-09-01
DOI: 10.1016/j.jpeds.2010.03.030
卷: 157, 期:3, 页:367-372
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pediatrics
研究领域[WOS]: Pediatrics
关键词[WOS]: WHOLE-BODY HYPOTHERMIA ; PERINATAL ASPHYXIA ; TERM INFANTS ; CEREBRAL-PALSY ; MORBIDITY ; OUTCOMES ; BRAIN ; RAT
英文摘要:

Objective To investigate the efficacy and safety of selective head cooling with mild systemic hypothermia in hypoxic-ischemic encephalopathy (HIE) in newborn infants.

Study design Infants with HIE were randomly assigned to the selective head cooling or control group. Selective head cooling was initiated within 6 hours after birth to a nasopharyngeal temperature of 34 degrees +/- 0.2 degrees C and rectal temperature of 34.5 degrees to 35.0 degrees C for 72 hours. Rectal temperature was maintained at 36.0 degrees to 37.5 degrees C in the control group. Neurodevelopmental outcome was assessed at 18 months of age. The primary outcome was a combined end point of death and severe disability.

Results One hundred ninety-four infants were available for analysis (100 and 94 infants in the selective head cooling and control group, respectively). For the selective head cooling and control groups, respectively, the combined outcome of death and severe disability was 31% and 49% (OR: 0.47; 95% CI: 0.26-0.84; P = .01), the mortality rate was 20% and 29% (OR: 0.62; 95% CI: 0.32-1.20; P = .16), and the severe disability rate was 14% (11/80) and 28% (19/67) (OR: 0.40; 95% CI: 0.17-0.92; P = .01).

Conclusions Selective head cooling combined with mild systemic hypothermia for 72 hours may significantly decrease the combined outcome of severe disability and death, as well as severe disability. (J Pediatr 2010; 157: 367-72).

语种: 英语
项目资助者: Ministry of Education of People&prime ; s Republic of China
WOS记录号: WOS:000281116100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63469
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Fudan Univ, Childrens Hosp, Shanghai 200433, Peoples R China
2.Beijing Univ, Hosp 1, Beijing 100871, Peoples R China
3.Zhejiang Univ, Childrens Hosp, Hangzhou, Zhejiang, Peoples R China

Recommended Citation:
Zhou, Wen-hao,Cheng, Guo-qiang,Shao, Xiao-mei,et al. Selective Head Cooling with Mild Systemic Hypothermia after Neonatal Hypoxic-Ischemic Encephalopathy: A Multicenter Randomized Controlled Trial in China[J]. JOURNAL OF PEDIATRICS,2010,157(3):367-372.
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