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学科主题临床医学
Leptomeningeal carcinomatosis as the initial manifestation of gastric adenocarcinoma: A case report
Guo, Jian-Wen1; Zhang, Xiao-Tian2,3; Chen, Xiao-Sheng1; Zhang, Xin-Chun1; Zheng, Guang-Juan1; Zhang, Bei-Ping1; Cai, Ye-Feng1
关键词Meningeal carcinomatosis Stomach neoplasms Endoscopes Gastrointestinal Spinal puncture Cytological techniques Pathology Clinical
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2014-02-28
DOI10.3748/wjg.v20.i8.2120
20期:8页:2120-2126
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; MENINGEAL CARCINOMATOSIS ; F-18-FDG PET ; PRESENTING MANIFESTATION ; SOLID TUMORS ; CANCER ; METASTASES ; SYMPTOM ; CT ; MR
英文摘要

Leptomeningeal involvement is usually reported as a secondary event in advanced gastric carcinoma. Leptomeningeal carcinomatosis (LMC), as the initial manifestation of asymptomatic gastric cancer, is exceedingly rare with only a few cases reported in recent years. The presenting neurologic symptoms include headache, vomiting and seizures and are usually clinically atypical. The diagnosis of LMC is made via identification of malignant cells that originate from epithelial cells in the cerebrospinal fluid by cytological examination and provides cues to track the primary tumor. Endoscopic examinations are crucial to confirm the presence of gastric cancer, and imaging studies, especially gadolinium-enhanced magnetic resonance imaging of the brain, are sometimes helpful in diagnosis. Thus far, there is no standard therapy for LMC, and despite all measures, the prognosis of the condition is extremely poor. Here, we report on the clinical features and diagnostic procedures for a patient with occult gastric cancer with Bormann type. macroscopic appearance and poor differentiation in pathology, who presented with LMC-induced neurological symptoms as the initial clinical manifestation. Additionally, we review the similar cases reported over the past years, making comparison among cases in order to provide more information for the future diagnosis. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.

语种英语
WOS记录号WOS:000331957900027
项目编号20104425120009
资助机构Research Fund for the Doctoral Program of Higher Education of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63471
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_消化肿瘤内科
作者单位1.Sch Oncol, Beijing 100142, Peoples R China
2.Guangzhou Univ Tradit Chinese Med, Guangdong Prov Hosp Tradit Chinese Med, Brain Ctr, Guangzhou 510120, Guangdong, Peoples R China
3.Peking Univ, Canc Hosp, Dept GI Oncol, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Guo, Jian-Wen,Zhang, Xiao-Tian,Chen, Xiao-Sheng,et al. Leptomeningeal carcinomatosis as the initial manifestation of gastric adenocarcinoma: A case report[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2014,20(8):2120-2126.
APA Guo, Jian-Wen.,Zhang, Xiao-Tian.,Chen, Xiao-Sheng.,Zhang, Xin-Chun.,Zheng, Guang-Juan.,...&Cai, Ye-Feng.(2014).Leptomeningeal carcinomatosis as the initial manifestation of gastric adenocarcinoma: A case report.WORLD JOURNAL OF GASTROENTEROLOGY,20(8),2120-2126.
MLA Guo, Jian-Wen,et al."Leptomeningeal carcinomatosis as the initial manifestation of gastric adenocarcinoma: A case report".WORLD JOURNAL OF GASTROENTEROLOGY 20.8(2014):2120-2126.
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