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学科主题: 临床医学
题名:
Leptomeningeal carcinomatosis as the initial manifestation of gastric adenocarcinoma: A case report
作者: Guo, Jian-Wen1; Zhang, Xiao-Tian2,3; Chen, Xiao-Sheng1; Zhang, Xin-Chun1; Zheng, Guang-Juan1; Zhang, Bei-Ping1; Cai, Ye-Feng1
关键词: Meningeal carcinomatosis ; Stomach neoplasms ; Endoscopes ; Gastrointestinal ; Spinal puncture ; Cytological techniques ; Pathology ; Clinical
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2014-02-28
DOI: 10.3748/wjg.v20.i8.2120
卷: 20, 期:8, 页:2120-2126
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: POSITRON-EMISSION-TOMOGRAPHY ; MENINGEAL CARCINOMATOSIS ; F-18-FDG PET ; PRESENTING MANIFESTATION ; SOLID TUMORS ; CANCER ; METASTASES ; SYMPTOM ; CT ; MR
英文摘要:

Leptomeningeal involvement is usually reported as a secondary event in advanced gastric carcinoma. Leptomeningeal carcinomatosis (LMC), as the initial manifestation of asymptomatic gastric cancer, is exceedingly rare with only a few cases reported in recent years. The presenting neurologic symptoms include headache, vomiting and seizures and are usually clinically atypical. The diagnosis of LMC is made via identification of malignant cells that originate from epithelial cells in the cerebrospinal fluid by cytological examination and provides cues to track the primary tumor. Endoscopic examinations are crucial to confirm the presence of gastric cancer, and imaging studies, especially gadolinium-enhanced magnetic resonance imaging of the brain, are sometimes helpful in diagnosis. Thus far, there is no standard therapy for LMC, and despite all measures, the prognosis of the condition is extremely poor. Here, we report on the clinical features and diagnostic procedures for a patient with occult gastric cancer with Bormann type. macroscopic appearance and poor differentiation in pathology, who presented with LMC-induced neurological symptoms as the initial clinical manifestation. Additionally, we review the similar cases reported over the past years, making comparison among cases in order to provide more information for the future diagnosis. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.

语种: 英语
所属项目编号: 20104425120009
项目资助者: Research Fund for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000331957900027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63471
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Sch Oncol, Beijing 100142, Peoples R China
2.Guangzhou Univ Tradit Chinese Med, Guangdong Prov Hosp Tradit Chinese Med, Brain Ctr, Guangzhou 510120, Guangdong, Peoples R China
3.Peking Univ, Canc Hosp, Dept GI Oncol, Beijing 100142, Peoples R China

Recommended Citation:
Guo, Jian-Wen,Zhang, Xiao-Tian,Chen, Xiao-Sheng,et al. Leptomeningeal carcinomatosis as the initial manifestation of gastric adenocarcinoma: A case report[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2014,20(8):2120-2126.
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