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Noninvasive Surface Detection of Papillary Thyroid Carcinoma by Fourier Transform Infrared Spectroscopy
Zhang Weitao1; Tian Peirong1; Zhu Qing2; Zhang Yuanfu2; Cui Long1; Xu Zhi1
关键词Noninvasive detection Papillary thyroid carcinoma Fourier transform infrared(FTIR) spectroscopy Fisher&prime s discriminant analysis
刊名CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
2015-04-01
DOI10.1007/s40242-015-4354-5
31期:2页:198-202
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]CANCER ; MICROSPECTROSCOPY ; NODULE ; CELLS
英文摘要

Previously Fourier transform infrared(FTIR) spectroscopy has been applied to detecting thyroid cancer during operations and to discriminating cervical metastatic ones from non-metastatic lymph nodes. This study explored the possibility of establishing a sensitive, accurate and noninvasive screen or diagnosis by preoperative FTIR spectroscopy. 111 patients undergone a thyroid operation and 50 healthy volunteers were enrolled in the study. The FTIR spectra were obtained by two mid-infrared optical fibers with an attenuated total reflectance(ATR) probe closely contacting the subjects′ skin on the thyroid nodules. The FTIR spectra obtained from normal thyroid, nodular goiter(NG) and papillary thyroid carcinoma(PTC) patients were compared. A Fisher′s discriminant analysis was created based on these data. There were 41 PTC patients and 70 NG patients according to their histopathological examinations. A total of 23(of 39) parameters were statistically different among the three groups(P<0.05). The F-1300 and F-1080 parameters were significantly different between the three groups. In total, 9 out of 39 FTIR parameters were selected as independent factors by the Wilks′ lambda stepwise discriminant analysis. The discrimination accuracy of papillary thyroid carcinoma in the three groups was 88.8%. Surface detection of PTC by FTIR spectroscopy is feasible. FTIR spectroscopy can be used for rapid and noninvasive PTC screen and auxiliary diagnosis.

语种英语
WOS记录号WOS:000354441500007
项目编号2122059 ; B59427-01 ; BYSY201207
资助机构Natural Science Foundation of Beijing City, China ; Clinical Research Project of Peking University Third Hospital, China ; Major Research Project of Peking University Third Hospital, China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63475
专题北京大学第三临床医学院_普通外科
作者单位1.Peking Univ, Dept Gen Surg, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang Weitao,Tian Peirong,Zhu Qing,et al. Noninvasive Surface Detection of Papillary Thyroid Carcinoma by Fourier Transform Infrared Spectroscopy[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2015,31(2):198-202.
APA Zhang Weitao,Tian Peirong,Zhu Qing,Zhang Yuanfu,Cui Long,&Xu Zhi.(2015).Noninvasive Surface Detection of Papillary Thyroid Carcinoma by Fourier Transform Infrared Spectroscopy.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,31(2),198-202.
MLA Zhang Weitao,et al."Noninvasive Surface Detection of Papillary Thyroid Carcinoma by Fourier Transform Infrared Spectroscopy".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 31.2(2015):198-202.
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