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An Update of Radiolabeled Bombesin Analogs for Gastrin-Releasing Peptide Receptor Targeting
Yu, Zilin1,2; Ananias, Hildo J. K.2; Carlucci, Giuseppe1,2; Hoving, Hilde D.2; Helfrich, Wijnand3; Dierckx, Rudi A. J. O.1,5; Wang, Fan4; de Jong, Igle J.2; Elsinga, Philip H.1,5
关键词Bombesin GRPR prostate cancer Bone Metastasis Pet Spect Targeting Imaging
刊名CURRENT PHARMACEUTICAL DESIGN
2013-06-01
19期:18页:3329-3341
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; IMPROVING TUMOR UPTAKE ; PROSTATE-CANCER ; POSITIVE TUMORS ; BIFUNCTIONAL CHELATORS ; BIOLOGICAL EVALUATION ; PEG(4) LINKERS ; IMAGING AGENT ; BREAST-CANCER ; RGD DIMERS
英文摘要

Prostate cancer is a critical public health problem in USA and Europe. New non-invasive imaging methods are urgently needed, due to the low accuracy and specificity of current screen methods and the desire of localizing primary prostate cancer and bone metastasis. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are the non-invasive and sensitive imaging methods which have been widely used for diagnosing diseases in the clinic. Lack of suitable radiotracers is the major issue for nuclear imaging of prostate cancer, although radiolabeled bombesin (BN) peptides targeting the Gastrin-Releasing Peptide Receptor (GRPR) on tumor cells are widely investigated. In this review we discuss the recent trends in the development of GRPR-targeted radiopharmaceuticals based on BN analogs with regard to their potential for imaging and therapy of GRPR-expressing malignancies. Following a brief introduction of GRPR and bombesin peptides, we summarize the properties of prostate cancer specific radiolabeled bombesins. New bombesin tracers published in the last five years are reviewed and compared according to their novelties in biomolecules, radionuclides, labeling methods, bifunctional chelators and linkers. Hot topics such as multimerization, application of agonists and antagonists are highlighted in the review. Lastly, a few clinical trials of cancer nuclear imaging with radiolabeled bombesin have been discussed.

语种英语
WOS记录号WOS:000318156100015
项目编号03O-203
资助机构CTMM, project PCMM
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63476
专题北京大学医药卫生分析中心
作者单位1.Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, Groningen, Netherlands
2.Univ Groningen, Univ Med Ctr Groningen, Dept Urol, Groningen, Netherlands
3.Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Groningen, Netherlands
4.Peking Univ, Med Isotopes Res Ctr, Beijing 100871, Peoples R China
5.Univ Ghent, Dept Nucl Med, B-9000 Ghent, Belgium
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Yu, Zilin,Ananias, Hildo J. K.,Carlucci, Giuseppe,et al. An Update of Radiolabeled Bombesin Analogs for Gastrin-Releasing Peptide Receptor Targeting[J]. CURRENT PHARMACEUTICAL DESIGN,2013,19(18):3329-3341.
APA Yu, Zilin.,Ananias, Hildo J. K..,Carlucci, Giuseppe.,Hoving, Hilde D..,Helfrich, Wijnand.,...&Elsinga, Philip H..(2013).An Update of Radiolabeled Bombesin Analogs for Gastrin-Releasing Peptide Receptor Targeting.CURRENT PHARMACEUTICAL DESIGN,19(18),3329-3341.
MLA Yu, Zilin,et al."An Update of Radiolabeled Bombesin Analogs for Gastrin-Releasing Peptide Receptor Targeting".CURRENT PHARMACEUTICAL DESIGN 19.18(2013):3329-3341.
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