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学科主题: 临床医学
题名:
Comparison of Different Loading Dose of Celecoxib on Postoperative Anti-inflammation and Analgesia in Patients Undergoing Endoscopic Nasal Surgery-200 mg Is Equivalent to 400 mg
作者: Zhao, Hong1; Feng, Yi1; Wang, Ying1; Yang, Baxian1; Xing, Zhimin2
关键词: COX-2 Inhibitor ; Prostaglandin ; Preventive Analgesia
刊名: PAIN MEDICINE
发表日期: 2011
DOI: 10.1111/j.1526-4637.2011.01196.x
卷: 12, 期:8, 页:1267-1275
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: RANDOMIZED CONTROLLED-TRIAL ; PAIN MANAGEMENT ; ANTIINFLAMMATORY DRUGS ; TONSILLECTOMY ; RECOVERY ; RISK
英文摘要:

Objective. To demonstrate the efficacy and non-inferiority of loading dose of celecoxib 200 mg compared with 400 mg in pain management after endoscopic nasal surgery.

Design. A prospective randomized controlled study.

Setting. A university hospital.

Patients. Consecutive 120 patients undergoing endoscopic nasal surgery under general anesthesia were randomly assigned to three groups of 40 patients each, celecoxib 400 mg, celecoxib 200 mg, or a control group with no celecoxib.

Interventions. Patients received different doses of celecoxib as described 1 hour before anesthesia. Two celecoxib groups received celecoxib 200 mg every 12 hours until the fifth day after surgery.

Outcome Measures. Noninferiority could be claimed if the lower limit of the confidence interval (CI) for pain score difference was greater than -0.6. At 0, 6, and 48 hours after surgery, prostaglandin E(2) (PGE(2)) and thromboxane A(2) (TXA(2)) to prostaglandin I(2) (PGI(2)) ratios were measured from incision drainage and in plasma.

Results. Estimated difference between two loading doses for pain scores over 5 days was 0.275 (95% CI -0.255 to 0.805, P > 0.05), indicating the noninferiority of celecoxib 200-400 mg. Local PGE(2) at 6 hours and 48 hours positively correlated with pain scores, with correlation coefficients 0.371 (P = 0.005) and 0.288 (P = 0.033). Systemic TXA(2) to PGI(2) ratios did not differ among groups.

Conclusions. An initial dose of celecoxib 200 mg was equivalent to celecoxib 400 mg with regard to the margin previously specified at -0.6 in reducing moderate postoperative pain in endoscopic nasal surgery both in analgesic efficacy and anti-inflammatory property. One hundred and twenty patients were included in this prospective randomized controlled study. Patients treated with celecoxib had lower pain scores than controls, pain scores correlating with local PGE(2) level. An initial dose of celecoxib 200 mg was equivalent to 400 mg in reducing moderate pain after endoscopic nasal surgery.

语种: 英语
所属项目编号: IR8267
项目资助者: Pfizer for biochemical tests
WOS记录号: WOS:000293997700018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63477
Appears in Collections:北京大学第二临床医学院_麻醉科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Anesthesiol, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Otolaryngol, Beijing, Peoples R China

Recommended Citation:
Zhao, Hong,Feng, Yi,Wang, Ying,et al. Comparison of Different Loading Dose of Celecoxib on Postoperative Anti-inflammation and Analgesia in Patients Undergoing Endoscopic Nasal Surgery-200 mg Is Equivalent to 400 mg[J]. PAIN MEDICINE,2011,12(8):1267-1275.
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