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学科主题基础医学
Synthesis and characterization of a six-coordinate monomeric Mn(III) complex with SOD-like activity
Shi, W; Liu, Y; Liu, B; Song, YG; Xu, YK; Wang, HM; Sha, YL; Xu, GZ; Styring, S; Huang, P
关键词Manganese(III) 2-o-hydroxyphenylbenzimidazole pyridine X-ray structure superoxide dismutase superoxide ion reactivity 2,2-dimethyl-3,4-dihydro-2H-pyrrole-1-oxide spin trap pyrogallol autoxidation
刊名JOURNAL OF COORDINATION CHEMISTRY
2006-01-20
DOI10.1080/00958970500249814
59期:2页:119-130
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Inorganic & Nuclear
研究领域[WOS]Chemistry
关键词[WOS]MANGANESE SUPEROXIDE-DISMUTASE ; ELECTRON-TRANSFER ; THERMUS-THERMOPHILUS ; CRYSTAL-STRUCTURE ; CYANINE DYES ; MIMICS ; SITE ; DISPROPORTIONATION ; METALLOPORPHYRINS ; REACTIVITY
英文摘要

The complex [Mn-III(HL)(L)(py)(CH3OH)](CH3OH)-C-. (H2L=2-ortho-hydroxyphenylbenzimidazole, py pyridine), 1, has been characterized spectroscopically and by X-ray crystallography. The complex is triclinic, space group P-1(-) with a = 10.396(2), b = 10.7340(10), c = 15.193(2) angstrom, alpha = 73.193(4)degrees, beta = 76.283(8)degrees, gamma = 61.400(40)degrees, V = 1415.1(4)angstrom(3), Z = 2, D-c = 1.445 Mg m(-3), M-r = 615.56, mu = 0.515 mm(-1), F(000) = 640, R = 0.0631, wR = 0.1525. Manganese is six-coordinate in an N3O3 ligand sphere created by two bidentate H2L ligands and solvent molecules with a slightly distorted, axially elongated octahedral geometry. Electronic absorption spectra show pi-pi* and Ligand Metal Charge Transfer (LMCT) transitions in the UV region and d-d transitions in the visible region. Solvent molecules coordinated to the Mn(III) ion in the crystal are thought to retain their coordination in solution. It is shown that 1 has reaction activity with the superoxide ion, as indicated by inhibition of pyrogallol autoxidation and by spin trapping electron paramagnetic resonance (EPR) spectroscopy. The N3O3 ligand set in 1 is similar to that in native MnSOD (superoxide dismutatase) in the substrate-bound state. The correlation between the ligand set in 1 and its reaction with the superoxide ion is discussed.

语种英语
WOS记录号WOS:000235500600001
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63478
Collection北京大学基础医学院_生物物理学系
作者单位1.Chinese Acad Sci, State Key Lab Struct Chem Unstable & Stable Speci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biophys, Beijing 10083, Peoples R China
3.Uppsala Univ, Dept Mol Biomimet, S-75236 Uppsala, Sweden
4.Lund Univ, Ctr Chem & Chem Engn, Dept Biochem, S-22100 Lund, Sweden
Recommended Citation
GB/T 7714
Shi, W,Liu, Y,Liu, B,et al. Synthesis and characterization of a six-coordinate monomeric Mn(III) complex with SOD-like activity[J]. JOURNAL OF COORDINATION CHEMISTRY,2006,59(2):119-130.
APA Shi, W.,Liu, Y.,Liu, B.,Song, YG.,Xu, YK.,...&Huang, P.(2006).Synthesis and characterization of a six-coordinate monomeric Mn(III) complex with SOD-like activity.JOURNAL OF COORDINATION CHEMISTRY,59(2),119-130.
MLA Shi, W,et al."Synthesis and characterization of a six-coordinate monomeric Mn(III) complex with SOD-like activity".JOURNAL OF COORDINATION CHEMISTRY 59.2(2006):119-130.
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