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学科主题: 基础医学
题名:
Synthesis and characterization of a six-coordinate monomeric Mn(III) complex with SOD-like activity
作者: Shi, W; Liu, Y; Liu, B; Song, YG; Xu, YK; Wang, HM; Sha, YL; Xu, GZ; Styring, S; Huang, P
关键词: Manganese(III) ; 2-o-hydroxyphenylbenzimidazole ; pyridine ; X-ray structure ; superoxide dismutase ; superoxide ion reactivity ; 2,2-dimethyl-3,4-dihydro-2H-pyrrole-1-oxide ; spin trap ; pyrogallol autoxidation
刊名: JOURNAL OF COORDINATION CHEMISTRY
发表日期: 2006-01-20
DOI: 10.1080/00958970500249814
卷: 59, 期:2, 页:119-130
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Inorganic & Nuclear
研究领域[WOS]: Chemistry
关键词[WOS]: MANGANESE SUPEROXIDE-DISMUTASE ; ELECTRON-TRANSFER ; THERMUS-THERMOPHILUS ; CRYSTAL-STRUCTURE ; CYANINE DYES ; MIMICS ; SITE ; DISPROPORTIONATION ; METALLOPORPHYRINS ; REACTIVITY
英文摘要:

The complex [Mn-III(HL)(L)(py)(CH3OH)](CH3OH)-C-. (H2L=2-ortho-hydroxyphenylbenzimidazole, py pyridine), 1, has been characterized spectroscopically and by X-ray crystallography. The complex is triclinic, space group P-1(-) with a = 10.396(2), b = 10.7340(10), c = 15.193(2) angstrom, alpha = 73.193(4)degrees, beta = 76.283(8)degrees, gamma = 61.400(40)degrees, V = 1415.1(4)angstrom(3), Z = 2, D-c = 1.445 Mg m(-3), M-r = 615.56, mu = 0.515 mm(-1), F(000) = 640, R = 0.0631, wR = 0.1525. Manganese is six-coordinate in an N3O3 ligand sphere created by two bidentate H2L ligands and solvent molecules with a slightly distorted, axially elongated octahedral geometry. Electronic absorption spectra show pi-pi* and Ligand Metal Charge Transfer (LMCT) transitions in the UV region and d-d transitions in the visible region. Solvent molecules coordinated to the Mn(III) ion in the crystal are thought to retain their coordination in solution. It is shown that 1 has reaction activity with the superoxide ion, as indicated by inhibition of pyrogallol autoxidation and by spin trapping electron paramagnetic resonance (EPR) spectroscopy. The N3O3 ligand set in 1 is similar to that in native MnSOD (superoxide dismutatase) in the substrate-bound state. The correlation between the ligand set in 1 and its reaction with the superoxide ion is discussed.

语种: 英语
WOS记录号: WOS:000235500600001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63478
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Struct Chem Unstable & Stable Speci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biophys, Beijing 10083, Peoples R China
3.Uppsala Univ, Dept Mol Biomimet, S-75236 Uppsala, Sweden
4.Lund Univ, Ctr Chem & Chem Engn, Dept Biochem, S-22100 Lund, Sweden

Recommended Citation:
Shi, W,Liu, Y,Liu, B,et al. Synthesis and characterization of a six-coordinate monomeric Mn(III) complex with SOD-like activity[J]. JOURNAL OF COORDINATION CHEMISTRY,2006,59(2):119-130.
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