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学科主题临床医学
Plasma Hydrogen Sulfide in Differential Diagnosis between Vasovagal Syncope and Postural Orthostatic Tachycardia Syndrome in Children
Zhang, Fengwen1; Li, Xueying2; Stella, Chen3; Chen, Li1; Liao, Ying1; Tang, Chaoshu4; Jin, Hongfang1; Du, Junbao1,5
刊名JOURNAL OF PEDIATRICS
2012-02-01
DOI10.1016/j.jpeds.2011.08.008
160期:2页:227-231
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics
研究领域[WOS]Pediatrics
关键词[WOS]SULFUR-COMPOUNDS ; H2S ; BLOOD ; ELECTRODE ; TILT ; RATS ; GAS
英文摘要

Objective To explore the predictive value of plasma hydrogen sulfide (H(2)S) in differentiating between vasovagal syncope (VVS) and postural orthostatic tachycardia syndrome (POTS) in children.

Study design Patients were divided between the POTS group (n = 60) and VVS group (n = 17) by using either the head-up test or head-up tilt test. Twenty-eight healthy children were selected for the control group. Plasma concentrations of H(2)S were determined for children in all groups (POTS, VVS, and control).

Results Plasma levels of H(2)S were significantly higher in children with VVS (95.3 +/- 3.8 mu mol/L) and POTS (100.9 +/- 2.1 mu mol/L) than in children in the control group (82.6 +/- 6.5 mu mol/L). Compared with the VVS group, the POTS group had plasma levels of H(2)S that were significantly increased. The receiver operating characteristic curve for the predictive value of H(2)S differentiation of VVS from POTS showed a H(2)S plasma level of 98 mu mol/L as the cutoff value for high probability of distinction. Such a level produced both high sensitivity (90%) and specificity (80%) rates of correctly discriminating between patients with VVS and patients with POTS.

Conclusion H(2)S plasma level has both high sensitivity and specificity rates to predict the probability of correctly differentiating between patients with VVS and patients with POTS. (J Pediatr 2012;160:227-31).

语种英语
WOS记录号WOS:000299112400015
项目编号2007-2003 ; D10100050010059 ; 30821001 ; 2011CB503904
资助机构Capital Medical Scientific Development Project, China ; Beijing Science and Technology Project, China ; National Natural Science Foundation of China ; Major Basic Research Project of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63479
专题北京大学第一临床医学院_儿科
北京大学基础医学院
北京大学第一临床医学院_医学统计室
作者单位1.Peking Univ, Dept Stat, Hosp 1, Beijing 100034, Peoples R China
2.Minist Educ, Key Lab Mol Cardiol, Taipei, Taiwan
3.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
4.Univ Calif San Diego, Dept Biochem & Cellular Biol, La Jolla, CA 92093 USA
5.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Fengwen,Li, Xueying,Stella, Chen,et al. Plasma Hydrogen Sulfide in Differential Diagnosis between Vasovagal Syncope and Postural Orthostatic Tachycardia Syndrome in Children[J]. JOURNAL OF PEDIATRICS,2012,160(2):227-231.
APA Zhang, Fengwen.,Li, Xueying.,Stella, Chen.,Chen, Li.,Liao, Ying.,...&Du, Junbao.(2012).Plasma Hydrogen Sulfide in Differential Diagnosis between Vasovagal Syncope and Postural Orthostatic Tachycardia Syndrome in Children.JOURNAL OF PEDIATRICS,160(2),227-231.
MLA Zhang, Fengwen,et al."Plasma Hydrogen Sulfide in Differential Diagnosis between Vasovagal Syncope and Postural Orthostatic Tachycardia Syndrome in Children".JOURNAL OF PEDIATRICS 160.2(2012):227-231.
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