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学科主题临床医学
CARD9 Deficiencies Linked to Impaired Neutrophil Functions Against Phialophora verrucosa
Liang, Pin1,2,3; Wang, Xiaowen1,2,3; Wang, Runchao1,2,3; Wan, Zhe1,2,3; Han, Wenling4; Li, Ruoyu1,2,3
关键词Phialophora verrucosa CARD9 Neutrophil ROS Phagocytosis Pro-inflammatory cytokines
刊名MYCOPATHOLOGIA
2015-06-01
DOI10.1007/s11046-015-9877-2
179期:5-6页:347-357
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
研究领域[WOS]Mycology
关键词[WOS]CANDIDA-ALBICANS ; OXIDATIVE BURST ; BLACK YEASTS ; PHEOHYPHOMYCOSIS ; SUSCEPTIBILITY ; PHAGOCYTOSIS ; INFLAMMATION ; RECRUITMENT ; COMPLEMENT ; MECHANISMS
英文摘要

Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor molecule that is critical for NF-kappa B activation and forms a complex with B cell lymphoma 10 and mucosa-associated lymphoid tissue lymphoma translocation gene 1 that mediates C-type lectin receptors (CLRs)-triggered intracellular signaling during antifungal immunity. However, the role of CARD9 in the host defense against Phialophora verrucosa (P. verrucosa) infection remains to be elucidated. In the present study, we investigated the functions of polymorphonuclear neutrophils (PMNs) from patients with CARD9 deficiencies against P. verrucosa. By isolating PMNs from patients and healthy blood donors and subsequently challenging the cells with P. verrucosa, we demonstrated that, compared with healthy donors, CARD9-deficient PMNs exhibited defects in P. verrucosa killing and pro-inflammatory cytokine productions, which can be rescued in the presence of serum; however, the CARD9-deficient PMNs exhibited normal reactive oxygen species generation and phagocytotic ability. In conclusion, our results indicate that CARD9 is indispensable for P. verrucosa killing by PMNs, and serum opsonization acts as a CARD9-independent way, which could be a promising immunotherapy in the future.

语种英语
WOS记录号WOS:000354488000002
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63483
专题北京大学第一临床医学院_皮肤性病科
北京大学基础医学院
作者单位1.Peking Univ, Res Ctr Med Mycol, Beijing 100871, Peoples R China
2.Beijing Key Lab Mol Diag Dermatoses, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Dermatol, Beijing, Peoples R China
4.Peking Univ, Ctr Human Dis Genom, Key Lab Med Immunol, Dept Immunol,Sch Basic Med Sci,Hlth Sci Ctr,Minis, Beijing, Peoples R China
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Liang, Pin,Wang, Xiaowen,Wang, Runchao,et al. CARD9 Deficiencies Linked to Impaired Neutrophil Functions Against Phialophora verrucosa[J]. MYCOPATHOLOGIA,2015,179(5-6):347-357.
APA Liang, Pin,Wang, Xiaowen,Wang, Runchao,Wan, Zhe,Han, Wenling,&Li, Ruoyu.(2015).CARD9 Deficiencies Linked to Impaired Neutrophil Functions Against Phialophora verrucosa.MYCOPATHOLOGIA,179(5-6),347-357.
MLA Liang, Pin,et al."CARD9 Deficiencies Linked to Impaired Neutrophil Functions Against Phialophora verrucosa".MYCOPATHOLOGIA 179.5-6(2015):347-357.
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