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学科主题: 临床医学
题名:
Serum cystatin C assay for the detection of early renal impairment in diabetic patients
作者: Xia, LH; Bing, XG; An, XT
关键词: cystatin C ; type 2 diabetes ; serum creatinine ; glomerular filtration rate ; creatinine clearance ; receiver operating characteristic
刊名: JOURNAL OF CLINICAL LABORATORY ANALYSIS
发表日期: 2004
DOI: 10.1002/jcla.20005
卷: 18, 期:1, 页:31-35
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: GLOMERULAR-FILTRATION-RATE ; SENSITIVE MARKER ; CREATININE ; GFR
英文摘要:

The ability to assess renal function in diabetes patients rapidly and early is of major importance. This study was designed to determine whether cystatin C can replace serum creatinine as the screening marker for reduced glomerular filtration rate (GFR) in type 2 diabetes patients. The study was performed on 51 type 2 diabetic patients. GFR was estimated by the plasma clearance of Tc-99m-DTPA. The correlation between Tc-99m-DTPA clearance and levels of serum cystatin C, serum creatinine, and creatinine clearance was determined. Sensitivity and specificity for the diagnosis of renal impairment (defined as GFR<68 ml/ min) were calculated by a receiver operating characteristic (ROC) curve for serum cystatin C, serum creatinine, and creatinine clearance. The correlation coefficients with Tc-99m-DTPA clearance were -0.744 for serum cystatin C, -0.658 for serum creatinine, and +0.625 for creatinine clearance (P<0.001). With a cutoff value of 68 mL/min, the area under the ROC curve (AUC) was 0.891 for cystatin C, 0.77 for creatinine, and 0.753 for creatinine clearance. The AUC was statistically different between serum cystatin C and creatinine clearance (P<0.05). The ROC plot indicates that cystatin C is superior to serum creatinine and creatinine clearance for detecting impaired GFR. Serum cystatin C appropriately reflects GFR in diabetes, and is more efficacious than serum creatinine and creatinine clearance in detecting reduced GFR in type 2 diabetes patients. (C) 2004 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000189148900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63484
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China

Recommended Citation:
Xia, LH,Bing, XG,An, XT. Serum cystatin C assay for the detection of early renal impairment in diabetic patients[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2004,18(1):31-35.
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