IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Serum cystatin C assay for the detection of early renal impairment in diabetic patients
Xia, LH; Bing, XG; An, XT
关键词cystatin C type 2 diabetes serum creatinine glomerular filtration rate creatinine clearance receiver operating characteristic
刊名JOURNAL OF CLINICAL LABORATORY ANALYSIS
2004
DOI10.1002/jcla.20005
18期:1页:31-35
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]GLOMERULAR-FILTRATION-RATE ; SENSITIVE MARKER ; CREATININE ; GFR
英文摘要

The ability to assess renal function in diabetes patients rapidly and early is of major importance. This study was designed to determine whether cystatin C can replace serum creatinine as the screening marker for reduced glomerular filtration rate (GFR) in type 2 diabetes patients. The study was performed on 51 type 2 diabetic patients. GFR was estimated by the plasma clearance of Tc-99m-DTPA. The correlation between Tc-99m-DTPA clearance and levels of serum cystatin C, serum creatinine, and creatinine clearance was determined. Sensitivity and specificity for the diagnosis of renal impairment (defined as GFR<68 ml/ min) were calculated by a receiver operating characteristic (ROC) curve for serum cystatin C, serum creatinine, and creatinine clearance. The correlation coefficients with Tc-99m-DTPA clearance were -0.744 for serum cystatin C, -0.658 for serum creatinine, and +0.625 for creatinine clearance (P<0.001). With a cutoff value of 68 mL/min, the area under the ROC curve (AUC) was 0.891 for cystatin C, 0.77 for creatinine, and 0.753 for creatinine clearance. The AUC was statistically different between serum cystatin C and creatinine clearance (P<0.05). The ROC plot indicates that cystatin C is superior to serum creatinine and creatinine clearance for detecting impaired GFR. Serum cystatin C appropriately reflects GFR in diabetes, and is more efficacious than serum creatinine and creatinine clearance in detecting reduced GFR in type 2 diabetes patients. (C) 2004 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000189148900006
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63484
专题北京大学第一临床医学院
作者单位Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Xia, LH,Bing, XG,An, XT. Serum cystatin C assay for the detection of early renal impairment in diabetic patients[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2004,18(1):31-35.
APA Xia, LH,Bing, XG,&An, XT.(2004).Serum cystatin C assay for the detection of early renal impairment in diabetic patients.JOURNAL OF CLINICAL LABORATORY ANALYSIS,18(1),31-35.
MLA Xia, LH,et al."Serum cystatin C assay for the detection of early renal impairment in diabetic patients".JOURNAL OF CLINICAL LABORATORY ANALYSIS 18.1(2004):31-35.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xia, LH]的文章
[Bing, XG]的文章
[An, XT]的文章
百度学术
百度学术中相似的文章
[Xia, LH]的文章
[Bing, XG]的文章
[An, XT]的文章
必应学术
必应学术中相似的文章
[Xia, LH]的文章
[Bing, XG]的文章
[An, XT]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。