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学科主题基础医学
Glial cell line-derived neurotrophic factor contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model
Fang, M; Wang, Y; He, QH; Sun, YX; Deng, LB; Wang, XM; Han, JS
关键词GDNF pain pathway nociception arthritis IB4
刊名NEUROSCIENCE
2003
DOI10.1016/S0306-4522(02)00958-2
117期:3页:503-512
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]ANTEROGRADE AXONAL-TRANSPORT ; MIDBRAIN DOPAMINERGIC-NEURONS ; SENSORY NEURONS ; PRIMARY AFFERENTS ; SPINAL-CORD ; DORSAL HORN ; SUBSTANCE-P ; IMMUNOCYTOCHEMICAL LOCALIZATION ; NERVOUS-SYSTEM ; GANGLION-CELLS
英文摘要

Neurotrophic factors, such as nerve growth factor and brain-derived neurotrophic factor, are members of the structurally related neurotrophin family that play important roles in pain modulation. Although there are also indications for the involvement of glial cell line-derived neurotrophic factor (GDNF), it is unclear whether and how GDNF is involved in inflammatory pain. In the present study, we studied the expression pattern of GDNF in dorsal root ganglia (DRG) and spinal cord, using confocal microscopy. We demonstrate that GDNF is well associated with nonpeptidergic pain pathway and that GDNF could possibly be anterogradely transported from DRG neurons to superficial spinal cord dorsal horn. We also studied the dynamic changes of GDNF expression in rats during chronic inflammation using injection of complete Freund′s adjuvant as a model of chronic pain. We found that GDNF was down-regulated in both dorsal root ganglia and spinal cords 2 weeks after arthritis induction. To assess the impact of this down-regulation on pain transmission, we used a function-blocking antibody against GDNF delivered intrathecally in the same chronic-pain animal models. Injection of this antibody to GDNF produced no immediate effect, but decreased the delayed, bilateral hyperalgesia induced from a unilateral injection of complete Freund′s adjuvant. The effect of this antibody coincided with the downregulation of GDNF immunoreactivity in response to inflammation, suggesting that GDNF supports biochemical changes that contribute to hyperalgesia. (C) 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.

语种英语
WOS记录号WOS:000181624300001
引用统计
被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63489
专题北京大学基础医学院_神经生物学系
作者单位Peking Univ, Neurosci Res Inst, Hlth Sci Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Fang, M,Wang, Y,He, QH,et al. Glial cell line-derived neurotrophic factor contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model[J]. NEUROSCIENCE,2003,117(3):503-512.
APA Fang, M.,Wang, Y.,He, QH.,Sun, YX.,Deng, LB.,...&Han, JS.(2003).Glial cell line-derived neurotrophic factor contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model.NEUROSCIENCE,117(3),503-512.
MLA Fang, M,et al."Glial cell line-derived neurotrophic factor contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model".NEUROSCIENCE 117.3(2003):503-512.
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