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学科主题基础医学
Electroacupuncture suppresses expression of gastric ghrelin and hypothalamic NPY in chronic food restricted rats
Tian, Nan; Wang, Fei; Tian, De-Run; Zou, Yuan; Wang, Shi-Wei; Guan, Li-Li; Shi, Yu-Shun; Chang, Jaw-Kang; Yang, Jun; Han, Ji-Sheng
关键词electroacupuncture ghrelin neuropeptide Y agouti-related peptide uncoupling protein 3
刊名PEPTIDES
2006-09-01
DOI10.1016/j.peptides.2006.03.010
27期:9页:2313-2320
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]HUMAN UNCOUPLING PROTEIN-3 ; SKELETAL-MUSCLE ; NEUROPEPTIDE-Y ; PERIPHERAL GHRELIN ; ARCUATE NUCLEUS ; PEPTIDE ; ACUPUNCTURE ; OBESITY ; METABOLISM ; HORMONE
英文摘要

Electroacupuncture (EA) has been reported to reduce body weight in overweight subjects in clinical practice, as well as in rats and mice with diet-induced obesity. In the present study, this effect of EA was tested in lean rats subjected to long-term food restriction (FR, food was offered only 1 h/day). Two hertz EA administered once every other day produced a further reduction in body weight in FR rats. Exploration of the mechanism involved revealed significant downregulation of the orexigenic peptides: ghrelin in the stomach, and neuropeptide Y (NPY) but not Agouti-related peptide (AgRP) in the hypothalamus, which was in line with the reduction in food intake in rats receiving EA stimulation as compared with those receiving restraint only. Uncoupling protein 3 (UCP3), involved in accelerating energy expenditure, was not significantly altered. These results suggest that the EA-induced body weight reduction was due mainly to a decrease in food intake rather than an increase in energy expenditure. A reduction in the orexigenic peptides ghrelin and NPY may be involved in the underlying mechanism. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000240379800035
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63491
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Phoenix Pharmaceut Inc, Belmont, CA 94002 USA
3.Tianjin Med Univ, Dept Anat, Tianjin 300070, Peoples R China
4.Dalian Med Univ, Dept Physiol, Dalian 116027, Peoples R China
推荐引用方式
GB/T 7714
Tian, Nan,Wang, Fei,Tian, De-Run,et al. Electroacupuncture suppresses expression of gastric ghrelin and hypothalamic NPY in chronic food restricted rats[J]. PEPTIDES,2006,27(9):2313-2320.
APA Tian, Nan.,Wang, Fei.,Tian, De-Run.,Zou, Yuan.,Wang, Shi-Wei.,...&Han, Ji-Sheng.(2006).Electroacupuncture suppresses expression of gastric ghrelin and hypothalamic NPY in chronic food restricted rats.PEPTIDES,27(9),2313-2320.
MLA Tian, Nan,et al."Electroacupuncture suppresses expression of gastric ghrelin and hypothalamic NPY in chronic food restricted rats".PEPTIDES 27.9(2006):2313-2320.
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