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Enantiomeric separation of angular-type pyranocoumarins from Peucedani Radix using AD-RH chiral column
Song, Yue-Lin1,2; Jing, Wang-Hui1; Tu, Peng-Fei2,3; Wang, Yi-Tao1
关键词Peucedani Radix enantiomers enantiomeric separation angular-type pyranocoumarins absolute configuration
刊名NATURAL PRODUCT RESEARCH
2014-04-18
DOI10.1080/14786419.2014.883397
28期:8页:545-550
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Chemistry, Medicinal
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]DRUG QIAN-HU ; (+/-)-PRAERUPTORIN ; METABOLISM ; COUMARINS
英文摘要

Enantiomers and diastereoisomers of angular-type pyranocoumarins (APs) are abundant in Peucedani Radix (Chinese name: Qian-hu), eliciting distinct activities in vitro and in vivo. Our ongoing investigation on APs yielded eight pairs of enantiomers (1a and 1b, 2a and 2b, 3a and 3b, 4a and 4b, 5a and 5b, 6a and 6b, 7a and 7b and 8a and 8b) via enantiomeric separation of trans-3 ′-angeloylkhellactone (1), trans-3 ′-acetyl-4 ′-isobutyrylkhellactone (2), trans-3 ′-acetyl-4 ′-angeloyl-khellactone (3), 3 ′-angeloyloxy-4 ′-oxo-3 ′,4 ′-dihydroseselin (4), cis-3 ′-acetyl-4 ′-angeloylkhellactone (5), cis-3 ′-isovaleryl-4 ′-acetylkhellactone (6), cis-3 ′-angeloyl-4 ′-isovalerylkhellactone (7) and cis-3 ′,4 ′-diisovalerylkhellactone (8), respectively, using semi-preparative AD-RH chiral column. All the compounds (1-8) were enantioseparated for the first time, while the absolute configurations of 2a, 2b, 6a and 8b were reported first.

语种英语
WOS记录号WOS:000334070700008
项目编号2009CB522707 ; 077/2011/A3 ; 074/2012/A3 ; MYRG 208 (Y3-L4)-ICMS11-WYT ; MRG012/WYT/2013/ICMS ; MRG013/WYT/2013/ICMS
资助机构National Basic Research Program of China 973 program ; Macao Science and Technology Development Fund ; University of Macau
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63500
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macao, Macao Sar, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Song, Yue-Lin,Jing, Wang-Hui,Tu, Peng-Fei,et al. Enantiomeric separation of angular-type pyranocoumarins from Peucedani Radix using AD-RH chiral column[J]. NATURAL PRODUCT RESEARCH,2014,28(8):545-550.
APA Song, Yue-Lin,Jing, Wang-Hui,Tu, Peng-Fei,&Wang, Yi-Tao.(2014).Enantiomeric separation of angular-type pyranocoumarins from Peucedani Radix using AD-RH chiral column.NATURAL PRODUCT RESEARCH,28(8),545-550.
MLA Song, Yue-Lin,et al."Enantiomeric separation of angular-type pyranocoumarins from Peucedani Radix using AD-RH chiral column".NATURAL PRODUCT RESEARCH 28.8(2014):545-550.
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