北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Enantiomeric separation of angular-type pyranocoumarins from Peucedani Radix using AD-RH chiral column
作者: Song, Yue-Lin1,2; Jing, Wang-Hui1; Tu, Peng-Fei2,3; Wang, Yi-Tao1
关键词: Peucedani Radix ; enantiomers ; enantiomeric separation ; angular-type pyranocoumarins ; absolute configuration
刊名: NATURAL PRODUCT RESEARCH
发表日期: 2014-04-18
DOI: 10.1080/14786419.2014.883397
卷: 28, 期:8, 页:545-550
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Chemistry, Medicinal
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: DRUG QIAN-HU ; (+/-)-PRAERUPTORIN ; METABOLISM ; COUMARINS
英文摘要:

Enantiomers and diastereoisomers of angular-type pyranocoumarins (APs) are abundant in Peucedani Radix (Chinese name: Qian-hu), eliciting distinct activities in vitro and in vivo. Our ongoing investigation on APs yielded eight pairs of enantiomers (1a and 1b, 2a and 2b, 3a and 3b, 4a and 4b, 5a and 5b, 6a and 6b, 7a and 7b and 8a and 8b) via enantiomeric separation of trans-3 ′-angeloylkhellactone (1), trans-3 ′-acetyl-4 ′-isobutyrylkhellactone (2), trans-3 ′-acetyl-4 ′-angeloyl-khellactone (3), 3 ′-angeloyloxy-4 ′-oxo-3 ′,4 ′-dihydroseselin (4), cis-3 ′-acetyl-4 ′-angeloylkhellactone (5), cis-3 ′-isovaleryl-4 ′-acetylkhellactone (6), cis-3 ′-angeloyl-4 ′-isovalerylkhellactone (7) and cis-3 ′,4 ′-diisovalerylkhellactone (8), respectively, using semi-preparative AD-RH chiral column. All the compounds (1-8) were enantioseparated for the first time, while the absolute configurations of 2a, 2b, 6a and 8b were reported first.

语种: 英语
所属项目编号: 2009CB522707 ; 077/2011/A3 ; 074/2012/A3 ; MYRG 208 (Y3-L4)-ICMS11-WYT ; MRG012/WYT/2013/ICMS ; MRG013/WYT/2013/ICMS
项目资助者: National Basic Research Program of China 973 program ; Macao Science and Technology Development Fund ; University of Macau
WOS记录号: WOS:000334070700008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63500
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macao, Macao Sar, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Song, Yue-Lin,Jing, Wang-Hui,Tu, Peng-Fei,et al. Enantiomeric separation of angular-type pyranocoumarins from Peucedani Radix using AD-RH chiral column[J]. NATURAL PRODUCT RESEARCH,2014,28(8):545-550.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Song, Yue-Lin]'s Articles
[Jing, Wang-Hui]'s Articles
[Tu, Peng-Fei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Song, Yue-Lin]‘s Articles
[Jing, Wang-Hui]‘s Articles
[Tu, Peng-Fei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace