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学科主题: 基础医学
题名:
Identification of promiscuous HLA-DR-restricted CD4(+) T-cell epitopes on the cancer-testis antigen HCA587
作者: Wen, Weigang1; Zhang, Lijie1; Peng, Jirun2; Chen, Juanjuan1; Hao, Jiaqing1; Li, Xiaofeng1; Qian, Xiaoping1; Zeng, Pumei1; Zhang, Yu1; Yin, Yanhui1
刊名: CANCER SCIENCE
发表日期: 2011-08-01
DOI: 10.1111/j.1349-7006.2011.01986.x
卷: 102, 期:8, 页:1455-1461
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; IMMUNE-RESPONSES ; DENDRITIC CELLS ; PEPTIDE EPITOPE ; HIGH-THROUGHPUT ; TUMOR-ANTIGENS ; IFN-GAMMA ; IN-VIVO ; MELANOMA ; ANTITUMOR
英文摘要:

The cancer testis antigen HCA587 is an attractive candidate for T cell-based immunotherapy because it is overexpressed in a wide spectrum of malignant tumors but not normal tissues, except testis. Several CTL epitopes derived from HCA587 have been described. Our aim was to identify helper T lymphocyte epitopes of HCA587 for the optimization of T cell-based immunotherapies against HCA587-expressing tumors. Candidate helper T lymphocyte epitopes for HCA587 were predicted using the SYFPEITHI algorithm and were tested for their ability to induce helper T lymphocyte responses by in vitro peptide vaccination of CD4(+) T lymphocytes from healthy individuals and hepatocellular carcinoma patients. Four CD4(+) T-cell epitopes for HCA587 (p43-57, p145-159, p186-200 and p249-263) were identified. Among them, the p43-57 epitope was shown to be naturally processed and presented by HCA587-expressing tumor cells as well as autologous dendritic cells pulsed with whole-protein HCA587. Notably, this epitope behaved as a promiscuous T-cell epitope as it stimulated T cells in the context of more than one HLA class II allele. Thus, p43-57 is the first HCA587-derived major histocompatibility complex class II-restricted epitope to fulfil all prerequisites for use as a peptide vaccine in patients with HCA587-expressing tumors. (Cancer Sci 2011; 102: 1455-1461)

语种: 英语
所属项目编号: 2006AA02Z486 ; 7071006
项目资助者: National 863 High Technology Program of China ; Beijing Municipal Government Foundation for Natural Sciences
WOS记录号: WOS:000292863700004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63502
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Ctr Hepatobiliary Surg, Hlth Sci Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Wen, Weigang,Zhang, Lijie,Peng, Jirun,et al. Identification of promiscuous HLA-DR-restricted CD4(+) T-cell epitopes on the cancer-testis antigen HCA587[J]. CANCER SCIENCE,2011,102(8):1455-1461.
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