|Protein-Losing Enteropathy in Systemic Lupus Erythematosus: 12 Years Experience from a Chinese Academic Center|
|Chen, Zhen1,2,3; Li, Meng-Tao1,2,3; Xu, Dong1,2,3; Yang, Hong2,4; Li, Jing1,2,3; Zhao, Jiu-Liang1,2,3; Zhang, Heng-Hui5; Han, Shao-Mei2,6; Xu, Tao2,6; Zeng, Xiao-Feng1,2,3|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||SERUM-ALBUMIN SCINTIGRAPHY ; CLASSIFICATION CRITERIA ; PATIENT ; GASTROENTEROPATHY ; PREDNISOLONE ; DIAGNOSIS ; DIARRHEA ; DISEASE ; EDEMA|
Objective: Protein-losing enteropathy (PLE) is a complication in some systemic lupus erythematosus (SLE) patients that is often misdiagnosed. With this study, we provide insight into clinical characteristics, laboratory characteristics, diagnostic tests, risk factors, treatment, and prognosis of the disease.
Methods: A retrospective, case-control study was performed in 44 patients with SLE-related PLE (PLE group) and 88 patients with active SLE (control group) admitted to our care from January 2000-January 2012. Risk factors for SLE-related PLE were examined, and we analyzed the accuracy of single and combined laboratory characteristics in discriminating SLE-related PLE from active SLE. Serum albumin and C3 levels were measured as outcome during and after treatment with corticosteroids and immunosuppressive agents.
Results: The PLE group had lower mean serum albumin and 24-hour urine protein levels, higher mean total plasma cholesterol levels, and greater frequencies of anti-SSA and SSB seropositivity compared with the control group. Anti-SSA seropositivity, hypoalbuminemia, and hypercholesterolemia were independent risk factors for SLE-related PLE. The simultaneous presence of serum albumin (<22 g/l) and 24-hour urine protein (<0.8 g/24 h) had high specificity, positive predictive value, negative predictive value, and positive likelihood ratio, a low negative likelihood ratio and no significant reduction in sensitivity. High dosage of glucocorticosteroid combined with cyclophosphomide were mostly prescribed for SLE-related PLE.
Conclusion: SLE-related PLE should be considered when an SLE patient presents with generalized edema, anti-SSA antibody seropositivity, hypercholesterolemia, severe hypoalbuminemia, and low 24-hour urine protein levels. Aggressive treatment for lupus might improve prognosis.
|项目编号||2008BAI59B02 ; 2012AA02A513 ; 201202004 ; 2012ZX09303006-002|
|资助机构||Chinese National Key Technology RD Program ; Ministry of Science and Technology ; Chinese National High Technology Research and Development Program ; Research Special Fund for Public Welfare Industry of Health, Ministry of Health ; National Major Scientific and Technological Special Project for "Significant New Drugs Development&prime ; &prime ; Ministry of Science and Technology|
|作者单位||1.Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing, Peoples R China|
2.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Rheumatol, Beijing 100730, Peoples R China
3.Peking Union Med Coll, Beijing 100021, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Gastroenterol, Beijing 100730, Peoples R China
5.Peking Univ, Peoples Hosp, Peking Univ Hepatol Inst, Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing 100871, Peoples R China
6.Chinese Acad Med Sci, Dept Epidemiol & Stat, Beijing 100730, Peoples R China
|Chen, Zhen,Li, Meng-Tao,Xu, Dong,et al. Protein-Losing Enteropathy in Systemic Lupus Erythematosus: 12 Years Experience from a Chinese Academic Center[J]. PLOS ONE,2014,9(12).|
|APA||Chen, Zhen.,Li, Meng-Tao.,Xu, Dong.,Yang, Hong.,Li, Jing.,...&Zeng, Xiao-Feng.(2014).Protein-Losing Enteropathy in Systemic Lupus Erythematosus: 12 Years Experience from a Chinese Academic Center.PLOS ONE,9(12).|
|MLA||Chen, Zhen,et al."Protein-Losing Enteropathy in Systemic Lupus Erythematosus: 12 Years Experience from a Chinese Academic Center".PLOS ONE 9.12(2014).|