IR@PKUHSC  > 北京大学药学院
学科主题药学
Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264
Huang, Fei-xia1; Yang, Wen-zhi1; Ye, Fei2,3; Tian, Jin-ying2,3; Hu, Hong-bo4; Feng, Lin-min1; Guo, De-an1; Ye, Min1
关键词Biotransformation PTP1B Syncephalastrum racemosum Triterpenoids Ursolic acid
刊名PHYTOCHEMISTRY
2012-10-01
DOI10.1016/j.phytochem.2012.06.020
82页:56-60
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]TYROSINE-PHOSPHATASE 1B ; NOCARDIA-SP NRRL-5646 ; OLEANOLIC ACID ; CYTOTOXIC ACTIVITY ; DERIVATIVES ; BIOTRANSFORMATION ; TRITERPENOIDS ; CONSTITUENTS ; ANTIOXIDANT ; INHIBITORS
英文摘要

Biotransformation of ursolic acid by the filamentous fungus Syncephalastrum racemosum (Cohn) Schroter AS 3.264 yielded five metabolites. Their structures were identified as 3 beta,21 beta-dihydroxy-urs-11-en-28-oic acid-13-lactone, 3 beta,7 beta,21 beta-trihydroxy-urs-11-en-28-oic acid-13-lactone, 1 beta,3 beta-dihydroxy-urs-12-en-21-one-28-oic acid, 1 beta,3 beta,21 beta-trihydroxy-urs-12-en-28-oic acid and 11,26-epoxy-3 beta,21 beta-dihydroxy-urs-12-en-28-oic acid based on NMR and MS spectroscopic analyses. The condensation reactions to form 28-oic acid-13-lactone ring and 11,26-epoxy ring are not frequently seen for the biotransformation of triterpenoids. One compound showed moderate inhibitory activity against protein tyrosine phosphatase 1B (PTP1B). (c) 2012 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000309317900006
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63505
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
3.Peking Union Med Coll, Beijing 100050, Peoples R China
4.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Huang, Fei-xia,Yang, Wen-zhi,Ye, Fei,et al. Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264[J]. PHYTOCHEMISTRY,2012,82:56-60.
APA Huang, Fei-xia.,Yang, Wen-zhi.,Ye, Fei.,Tian, Jin-ying.,Hu, Hong-bo.,...&Ye, Min.(2012).Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264.PHYTOCHEMISTRY,82,56-60.
MLA Huang, Fei-xia,et al."Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264".PHYTOCHEMISTRY 82(2012):56-60.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Huang, Fei-xia]的文章
[Yang, Wen-zhi]的文章
[Ye, Fei]的文章
百度学术
百度学术中相似的文章
[Huang, Fei-xia]的文章
[Yang, Wen-zhi]的文章
[Ye, Fei]的文章
必应学术
必应学术中相似的文章
[Huang, Fei-xia]的文章
[Yang, Wen-zhi]的文章
[Ye, Fei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。