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学科主题: 药学
题名:
Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264
作者: Huang, Fei-xia1; Yang, Wen-zhi1; Ye, Fei2,3; Tian, Jin-ying2,3; Hu, Hong-bo4; Feng, Lin-min1; Guo, De-an1; Ye, Min1
关键词: Biotransformation ; PTP1B ; Syncephalastrum racemosum ; Triterpenoids ; Ursolic acid
刊名: PHYTOCHEMISTRY
发表日期: 2012-10-01
DOI: 10.1016/j.phytochem.2012.06.020
卷: 82, 页:56-60
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]: TYROSINE-PHOSPHATASE 1B ; NOCARDIA-SP NRRL-5646 ; OLEANOLIC ACID ; CYTOTOXIC ACTIVITY ; DERIVATIVES ; BIOTRANSFORMATION ; TRITERPENOIDS ; CONSTITUENTS ; ANTIOXIDANT ; INHIBITORS
英文摘要:

Biotransformation of ursolic acid by the filamentous fungus Syncephalastrum racemosum (Cohn) Schroter AS 3.264 yielded five metabolites. Their structures were identified as 3 beta,21 beta-dihydroxy-urs-11-en-28-oic acid-13-lactone, 3 beta,7 beta,21 beta-trihydroxy-urs-11-en-28-oic acid-13-lactone, 1 beta,3 beta-dihydroxy-urs-12-en-21-one-28-oic acid, 1 beta,3 beta,21 beta-trihydroxy-urs-12-en-28-oic acid and 11,26-epoxy-3 beta,21 beta-dihydroxy-urs-12-en-28-oic acid based on NMR and MS spectroscopic analyses. The condensation reactions to form 28-oic acid-13-lactone ring and 11,26-epoxy ring are not frequently seen for the biotransformation of triterpenoids. One compound showed moderate inhibitory activity against protein tyrosine phosphatase 1B (PTP1B). (c) 2012 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009B02 ; 7102103
项目资助者: Scientific Research Foundation for the Returned Overseas Chinese Scholars (Ministry of Education, China) ; Beijing Nova Program ; Beijing Natural Science Foundation
WOS记录号: WOS:000309317900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63505
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
3.Peking Union Med Coll, Beijing 100050, Peoples R China
4.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China

Recommended Citation:
Huang, Fei-xia,Yang, Wen-zhi,Ye, Fei,et al. Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264[J]. PHYTOCHEMISTRY,2012,82:56-60.
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