北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese
作者: Wu Jun1; Zhao Hui Ru1; Zhang Hui Ying1; Ge Yan Ling1; Qiu Shuang1; Zhao Jie2; Song Ying2; Zhao Jing Zhong2; Lu Song Song2
关键词: Calibrated automated thrombogram ; Thrombin generation ; Age ; Heparin ; Low molecular weight heparin
刊名: BIOMEDICAL AND ENVIRONMENTAL SCIENCES
发表日期: 2014-05-01
DOI: 10.3967/bes2014.063
卷: 27, 期:5, 页:378-384
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: IN-VITRO ; PLASMA
英文摘要:

Objective Calibrated Automated Thrombogram(CAT) is a test to monitor the generation of thrombin. It can be described by four parameters: lag time, peak thrombin, endogenous thrombin potential (ETP) and time to peak (ttPeak). This study aims to determine the normal ranges of CAT parameters in Chinese, and evaluate whether thrombin generation is correlated with the concentration of heparin/low molecular weight heparin.

Methods Plasma from 120 healthy subjects were collected to determine the normal rangea of CAT parameters in Chinese. Normal plasma pool (NPP, n=25) spiked with different concentrations of heparin or enoxaparin were used to detecte CAT parameters. The overall and age specific normal ranges of CAT parameters were calculated using descriptive statistics method with mean +/- 2SD. The correlation between CAT parameters and age or concentrations of heparin, enoxaparin were analyzed with linear regression model.

Results The normal ranges for lag time, peak thrombin, ETP, ttPeak in the subjects were 3.648 +/- 2.465 min, 367.39 +/- 151.93 nmol/L, 2277 +/- 1030 nmol/L.min and 6.372 +/- 4.280 min respectively. Age was linearly correlated with lag time (r=-0.6583, P<0.0001), peak thrombin (r=0.4863, P<0.0001), ETP (r=0.3608, P<0.0014) and ttPeak (r=-0.6313, P<0.0001). The values of ETP/peak ratio were linearly correlated with concentrations of heparin.

Conclusion The normal ranges of four CAT parameters for Chinese were determined. CAT parameters are associated with age. ETP/peak ratio could be used to monitor the process of anticoagulation therapy.

语种: 英语
所属项目编号: 20110001120088
项目资助者: Ministry of Education of China
WOS记录号: WOS:000336619400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63506
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Beijing Jishuitan Hosp, Dept Lab Med, Beijing 100035, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Lab Med, Beijing 100044, Peoples R China

Recommended Citation:
Wu Jun,Zhao Hui Ru,Zhang Hui Ying,et al. Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2014,27(5):378-384.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu Jun]'s Articles
[Zhao Hui Ru]'s Articles
[Zhang Hui Ying]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu Jun]‘s Articles
[Zhao Hui Ru]‘s Articles
[Zhang Hui Ying]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace