IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese
Wu Jun1; Zhao Hui Ru1; Zhang Hui Ying1; Ge Yan Ling1; Qiu Shuang1; Zhao Jie2; Song Ying2; Zhao Jing Zhong2; Lu Song Song2
关键词Calibrated automated thrombogram Thrombin generation Age Heparin Low molecular weight heparin
刊名BIOMEDICAL AND ENVIRONMENTAL SCIENCES
2014-05-01
DOI10.3967/bes2014.063
27期:5页:378-384
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]IN-VITRO ; PLASMA
英文摘要

Objective Calibrated Automated Thrombogram(CAT) is a test to monitor the generation of thrombin. It can be described by four parameters: lag time, peak thrombin, endogenous thrombin potential (ETP) and time to peak (ttPeak). This study aims to determine the normal ranges of CAT parameters in Chinese, and evaluate whether thrombin generation is correlated with the concentration of heparin/low molecular weight heparin.

Methods Plasma from 120 healthy subjects were collected to determine the normal rangea of CAT parameters in Chinese. Normal plasma pool (NPP, n=25) spiked with different concentrations of heparin or enoxaparin were used to detecte CAT parameters. The overall and age specific normal ranges of CAT parameters were calculated using descriptive statistics method with mean +/- 2SD. The correlation between CAT parameters and age or concentrations of heparin, enoxaparin were analyzed with linear regression model.

Results The normal ranges for lag time, peak thrombin, ETP, ttPeak in the subjects were 3.648 +/- 2.465 min, 367.39 +/- 151.93 nmol/L, 2277 +/- 1030 nmol/L.min and 6.372 +/- 4.280 min respectively. Age was linearly correlated with lag time (r=-0.6583, P<0.0001), peak thrombin (r=0.4863, P<0.0001), ETP (r=0.3608, P<0.0014) and ttPeak (r=-0.6313, P<0.0001). The values of ETP/peak ratio were linearly correlated with concentrations of heparin.

Conclusion The normal ranges of four CAT parameters for Chinese were determined. CAT parameters are associated with age. ETP/peak ratio could be used to monitor the process of anticoagulation therapy.

语种英语
WOS记录号WOS:000336619400008
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63506
专题北京大学第二临床医学院
作者单位1.Beijing Jishuitan Hosp, Dept Lab Med, Beijing 100035, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Lab Med, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wu Jun,Zhao Hui Ru,Zhang Hui Ying,et al. Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2014,27(5):378-384.
APA Wu Jun.,Zhao Hui Ru.,Zhang Hui Ying.,Ge Yan Ling.,Qiu Shuang.,...&Lu Song Song.(2014).Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,27(5),378-384.
MLA Wu Jun,et al."Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 27.5(2014):378-384.
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