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学科主题: 精神卫生
题名:
Prolongation of T-2 relaxation times of hippocampus and amygdala in Alzheimer′s disease
作者: Wang, HL; Yuan, HS; Shu, L; Xie, JX; Zhang, D
关键词: Alzheimer&prime ; s disease ; vascular dementia ; magnetic resonance imaging ; T-2 ; relaxation time ; hippocampus ; amygdala
刊名: NEUROSCIENCE LETTERS
发表日期: 2004-06-10
DOI: 10.1016/j.neulet.2004.03.061
卷: 363, 期:2, 页:150-153
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: ENTORHINAL CORTEX ; MEMORY IMPAIRMENT ; MRI ; DEMENTIA
英文摘要:

There exists controversy on the MR T-2 relaxometry of hippocampus in Alzheimer′s disease (AD). The aim of our study was to examine whether there was a prolonged T-2 relaxation time (T-2) in hippocampus and amygdala in AD, and whether in AD, the relaxometry data correlated to cognitive performance. In a 1.5 T MR scanner, T-2 of hippocampus and amygdala was measured from 51 patients with AD, 23 subjects with vascular dementia (VaD) and 31 healthy elderly controls. The cognitive performance was assessed with the Alzheimer′s Disease Assessment Scale - Cognitive Subscale (ADAS-Cog). The AD patients had longer T-2 in hippocampus and amygdala than VaD subjects and healthy elderly controls. In AD, the right hippocampal T-2 was correlated with ADAS-Cog scores, whereas amygdaloid T-2 was not. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000221942300012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63507
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, HL,Yuan, HS,Shu, L,et al. Prolongation of T-2 relaxation times of hippocampus and amygdala in Alzheimer′s disease[J]. NEUROSCIENCE LETTERS,2004,363(2):150-153.
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