IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Paraplegia and Paraparesis From Intrathecal Methotrexate and Cytarabine Contaminated With Trace Amounts of Vincristine in China During 2007
Zeng, Guang1; Ma, Huilai; Wang, Xiangbo; Yan, Huifang; Wan, Xinhua; Jiang, Bin; Fontaine, Robert E.; Wu, Zhenglai; Lin, Shaobin; Ruan, Feng; Liu, Huihui
刊名JOURNAL OF CLINICAL ONCOLOGY
2011-05-01
DOI10.1200/JCO.2010.32.7072
29期:13页:1765-1770
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]ACUTE LYMPHOBLASTIC-LEUKEMIA ; CHEMOTHERAPY ; INJECTION ; MYELOPATHY
英文摘要

Purpose The production and administration of drugs used intrathecally requires special care to prevent contamination with neurotoxic agents. In 2007, we investigated a widespread outbreak of paraplegia and paraparesis among Chinese patients who received intrathecal drugs to identify the presumed contaminant and its source to prevent further cases.

Patients and Methods We defined a case as onset from January 1 to October 31, 2007, of bilateral flaccid paraparesis or paraplegia or retention and incontinence of stool or urine, in a patient receiving intrathecal drugs. Using a retrospective cohort approach, we selected 12 hospitals from all hospitals that had reported cases. In these hospitals, we identified all 448 patients (including 107 cases) who received intrathecal chemotherapy or chemoprophylaxis in 2007. We calculated attack rates and Mantel-Haenszel adjusted risk ratios for intrathecal drug type and lot.

Results All 12 hospitals used intrathecal methotrexate or cytarabine produced by one pharmaceutical plant. Only two lots of each drug were associated with cases. Lot-specific attack rates ranged from 42% to 100% (risk ratio, infinity; lower confidence bounds, 1.8 to 7.3). Vincristine production had immediately preceded production of the implicated lots on the same equipment. By using ultra performance liquid chromatography, we detected vincristine (0.28 to 18 mu g) in unused vials from implicated lots of methotrexate and cytarabine.

Conclusion Trace amounts of vincristine that contaminated intrathecal drugs caused a large outbreak of severe neurologic damage. Vincristine and other neurotoxic drugs should not be produced on any equipment that is also used for producing drugs that are to be administered intrathecally.

语种英语
WOS记录号WOS:000290090400034
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63508
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Ctr Dis Control & Prevent, Atlanta, GA USA
3.Natl Inst Occupat Hlth & Poison Control, Beijing, Peoples R China
4.Capital Med Univ, Xuan Wu Hosp, Beijing, Peoples R China
5.Chinese Ctr Dis Control & Prevent, Chinese Field Epidemiol Training Program, Beijing 100050, Peoples R China
6.Natl Inst Environm Hlth & Related Product Safety, Beijing, Peoples R China
7.Peking Union Med Coll, Beijing 100021, Peoples R China
推荐引用方式
GB/T 7714
Zeng, Guang,Ma, Huilai,Wang, Xiangbo,et al. Paraplegia and Paraparesis From Intrathecal Methotrexate and Cytarabine Contaminated With Trace Amounts of Vincristine in China During 2007[J]. JOURNAL OF CLINICAL ONCOLOGY,2011,29(13):1765-1770.
APA Zeng, Guang.,Ma, Huilai.,Wang, Xiangbo.,Yan, Huifang.,Wan, Xinhua.,...&Liu, Huihui.(2011).Paraplegia and Paraparesis From Intrathecal Methotrexate and Cytarabine Contaminated With Trace Amounts of Vincristine in China During 2007.JOURNAL OF CLINICAL ONCOLOGY,29(13),1765-1770.
MLA Zeng, Guang,et al."Paraplegia and Paraparesis From Intrathecal Methotrexate and Cytarabine Contaminated With Trace Amounts of Vincristine in China During 2007".JOURNAL OF CLINICAL ONCOLOGY 29.13(2011):1765-1770.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zeng, Guang]的文章
[Ma, Huilai]的文章
[Wang, Xiangbo]的文章
百度学术
百度学术中相似的文章
[Zeng, Guang]的文章
[Ma, Huilai]的文章
[Wang, Xiangbo]的文章
必应学术
必应学术中相似的文章
[Zeng, Guang]的文章
[Ma, Huilai]的文章
[Wang, Xiangbo]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。