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A survey on "Trojan Horse" peptides: Opportunities, issues and controlled entry to "Troy"
Shi, Nian-Qiu1,2; Qi, Xian-Rong2; Xiang, Bai2,3; Zhang, Yong4,5
关键词Cell-penetrating peptides Clinical development Non-specificity Organelle-specific delivery Controlled delivery strategies
刊名JOURNAL OF CONTROLLED RELEASE
2014-11-28
DOI10.1016/j.jconrel.2014.08.014
194页:53-70
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CELL-PENETRATING PEPTIDES ; HUMAN-IMMUNODEFICIENCY-VIRUS ; IRON-OXIDE NANOPARTICLES ; ARGININE-RICH PEPTIDES ; CENTRAL-NERVOUS-SYSTEM ; MESOPOROUS SILICA NANOPARTICLES ; PROTEIN TRANSDUCTION DOMAIN ; SOYBEAN-DERIVED STEROLS ; SMALL INTERFERING RNA ; TAT-FUSION PROTEINS
英文摘要

Cell-penetrating peptides (CPPs), often vividly termed as the "Trojan Horse" peptides, have attracted considerable interest for the intracellular delivery of a wide range of cargoes, such as small molecules, peptides, proteins, nucleic acids, contrast agents, nanocarriers and so on. Some preclinical and clinical developments of CPP conjugates demonstrate their promise as therapeutic agents for drug discovery. There is increasing evidence to suggest that CPPs have the potential to cross several bio-barriers (e. g., blood-brain barriers, intestinal mucosa, nasal mucosa and skin barriers). Despite revolutionary process in many aspects, there are a lot of basic issues unclear for these entities, such as internalization mechanisms, translocation efficiency, translocation kinetics, metabolic degradation, toxicity, side effect, distribution and non-specificity. Among them, non-specificity remains a major drawback for the in vivo application of CPPs in the targeted delivery of cargoes. So far, diverse organelle-specific CPPs or controlled delivery strategies have emerged and improved their specificity. In this review, we will look at the opportunities of CPPs in clinical development, bio-barriers penetration and nanocarriers delivery. Then, a series of basic problems of CPPs will be discussed. Finally, this paper will highlight the use of various controlled strategies in the organelle-specific delivery and targeted delivery of CPPs. The purpose of this review will be to emphasize most influential advance in this field and present a fundamental understanding for challenges and utilizations of CPPs. This will accelerate their translation as efficient vectors from the in vitro setting into the clinic arena, and retrieve the entry art to "Troy". (C) 2014 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000344229800006
引用统计
被引频次:52[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63512
专题北京大学药学院_药剂学系
作者单位1.Jilin Univ, Coll Life Sci, Changchun 130012, Peoples R China
2.Jilin Med Coll, Sch Pharm, Dept Pharmaceut, Fengman Dist 132013, Jilin, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
4.Hebei Med Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Shijiazhuang 050017, Peoples R China
5.China Shijiazhuang Pharmaceut Grp Co Inc, State Key Lab New Pharmaceut Preparat & Excipient, Shijiazhuang 050017, Peoples R China
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Shi, Nian-Qiu,Qi, Xian-Rong,Xiang, Bai,et al. A survey on "Trojan Horse" peptides: Opportunities, issues and controlled entry to "Troy"[J]. JOURNAL OF CONTROLLED RELEASE,2014,194:53-70.
APA Shi, Nian-Qiu,Qi, Xian-Rong,Xiang, Bai,&Zhang, Yong.(2014).A survey on "Trojan Horse" peptides: Opportunities, issues and controlled entry to "Troy".JOURNAL OF CONTROLLED RELEASE,194,53-70.
MLA Shi, Nian-Qiu,et al."A survey on "Trojan Horse" peptides: Opportunities, issues and controlled entry to "Troy"".JOURNAL OF CONTROLLED RELEASE 194(2014):53-70.
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