北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 药剂学系  > 期刊论文
学科主题: 药学
题名:
A survey on "Trojan Horse" peptides: Opportunities, issues and controlled entry to "Troy"
作者: Shi, Nian-Qiu1,2; Qi, Xian-Rong2; Xiang, Bai2,3; Zhang, Yong4,5
关键词: Cell-penetrating peptides ; Clinical development ; Non-specificity ; Organelle-specific delivery ; Controlled delivery strategies
刊名: JOURNAL OF CONTROLLED RELEASE
发表日期: 2014-11-28
DOI: 10.1016/j.jconrel.2014.08.014
卷: 194, 页:53-70
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CELL-PENETRATING PEPTIDES ; HUMAN-IMMUNODEFICIENCY-VIRUS ; IRON-OXIDE NANOPARTICLES ; ARGININE-RICH PEPTIDES ; CENTRAL-NERVOUS-SYSTEM ; MESOPOROUS SILICA NANOPARTICLES ; PROTEIN TRANSDUCTION DOMAIN ; SOYBEAN-DERIVED STEROLS ; SMALL INTERFERING RNA ; TAT-FUSION PROTEINS
英文摘要:

Cell-penetrating peptides (CPPs), often vividly termed as the "Trojan Horse" peptides, have attracted considerable interest for the intracellular delivery of a wide range of cargoes, such as small molecules, peptides, proteins, nucleic acids, contrast agents, nanocarriers and so on. Some preclinical and clinical developments of CPP conjugates demonstrate their promise as therapeutic agents for drug discovery. There is increasing evidence to suggest that CPPs have the potential to cross several bio-barriers (e. g., blood-brain barriers, intestinal mucosa, nasal mucosa and skin barriers). Despite revolutionary process in many aspects, there are a lot of basic issues unclear for these entities, such as internalization mechanisms, translocation efficiency, translocation kinetics, metabolic degradation, toxicity, side effect, distribution and non-specificity. Among them, non-specificity remains a major drawback for the in vivo application of CPPs in the targeted delivery of cargoes. So far, diverse organelle-specific CPPs or controlled delivery strategies have emerged and improved their specificity. In this review, we will look at the opportunities of CPPs in clinical development, bio-barriers penetration and nanocarriers delivery. Then, a series of basic problems of CPPs will be discussed. Finally, this paper will highlight the use of various controlled strategies in the organelle-specific delivery and targeted delivery of CPPs. The purpose of this review will be to emphasize most influential advance in this field and present a fundamental understanding for challenges and utilizations of CPPs. This will accelerate their translation as efficient vectors from the in vitro setting into the clinic arena, and retrieve the entry art to "Troy". (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30970785 ; 81273454 ; 81302725 ; 7132113 ; 2013CB932501 ; 2009CB930303 ; 20100001110056 ; BMU20110263 ; C2011206073 ; C2011319001
项目资助者: NSFC ; Beijing NSF ; National Basic Research Program ; Doctoral Foundation of the Ministry of Education ; Innovation Team of Ministry of Education ; Hebei NSF ; Hebei Provincial Natural Science Foundation of China-Shijiazhuang Pharmaceutical Group (CSPC) Foundation
WOS记录号: WOS:000344229800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63512
Appears in Collections:北京大学药学院_药剂学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Jilin Univ, Coll Life Sci, Changchun 130012, Peoples R China
2.Jilin Med Coll, Sch Pharm, Dept Pharmaceut, Fengman Dist 132013, Jilin, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
4.Hebei Med Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Shijiazhuang 050017, Peoples R China
5.China Shijiazhuang Pharmaceut Grp Co Inc, State Key Lab New Pharmaceut Preparat & Excipient, Shijiazhuang 050017, Peoples R China

Recommended Citation:
Shi, Nian-Qiu,Qi, Xian-Rong,Xiang, Bai,et al. A survey on "Trojan Horse" peptides: Opportunities, issues and controlled entry to "Troy"[J]. JOURNAL OF CONTROLLED RELEASE,2014,194:53-70.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shi, Nian-Qiu]'s Articles
[Qi, Xian-Rong]'s Articles
[Xiang, Bai]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shi, Nian-Qiu]‘s Articles
[Qi, Xian-Rong]‘s Articles
[Xiang, Bai]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace