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学科主题: 临床医学
题名:
Multicenter, Intraindividual Comparison of Single-Dose Gadobenate Dimeglumine and Double-Dose Gadopentetate Dimeglumine for MR Angiography of the Supra-Aortic Arteries (the Supra-Aortic VALUE Study)
作者: Li, Yanjun1; Li, X.2; Li, D.3; Lu, J.1; Xing, X.2; Yan, F.4; Li, Yuan5; Wang, X.6; Iezzi, R.7; De Cobelli, F.8
刊名: AMERICAN JOURNAL OF NEURORADIOLOGY
发表日期: 2013-04-01
DOI: 10.3174/ajnr.A3298
卷: 34, 期:4, 页:847-854
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: MAGNETIC-RESONANCE ANGIOGRAPHY ; SYMPTOMATIC CAROTID STENOSIS ; CONTRAST AGENTS ; DIAGNOSTIC-ACCURACY ; 3 TESLA ; GADOBUTROL ; ENDARTERECTOMY ; METAANALYSIS ; GADODIAMIDE ; LESIONS
英文摘要:

BACKGROUND AND PURPOSE: Gadobenate dimeglumine has markedly higher R1 relaxivity compared to gadopentetate dimeglumine meaning that lower doses can be used to achieve similar contrast enhancement. Our aim was to prospectively compare single-dose gadobenate dimeglumine with double-dose gadopentetate dimeglumine for contrast-enhanced MRA of the supra-aortic vasculature.

MATERIALS AND METHODS: Forty-six patients (37 men, 9 women; mean age, 63.5 +/- 10.1 years) with known or suspected steno-occlusive disease of the supra-aortic vessels underwent 2 identical CE-MRA examinations at 1.5T. Contrast agents were administered in randomized order, with the 2-fold greater volume of gadopentetate dimeglumine injected at a 2 times faster rate. Image assessment was performed by 3 independent blinded readers for vessel anatomic delineation, detection/exclusion of pathology, and global preference. Diagnostic performance (sensitivity, specificity, accuracy, PPV, and NPV) for detection of >= 60% stenosis was determined for 39/46 patients who underwent preinterventional DSA. Data were analyzed by using the Wilcoxon signed-rank, McNemar, and Wald tests in terms of the noninferiority of single-dose gadobenate dimeglumine compared with double-dose gadopentetate dimeglumine. Quantitative enhancement (signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR)) was also compared.

RESULTS: All images were technically adequate. No differences (P = 1.0) were noted by any reader for any qualitative parameter. All readers considered single-dose gadobenate dimeglumine and double-dose gadopentetate dimeglumine equivalent in at least 42/46 patients (91.3% three-reader agreement) for all parameters. Nonsignificant superiority for gadobenate dimeglumine was reported for all diagnostic performance indicators (sensitivity: 82.7%-88.5% versus 75.0%-80.8%; specificity: 96.4%-98.6% versus 94.6%-98.6%; accuracy: 94.6%-96.1% versus 92.4%-94.9%; PPV: 81.5%-91.5% versus 73.7%-90.7%; NPV: 96.8%-97.8% versus 95.4%-96.4%). No differences (P>.05) in quantitative enhancement were noted.

CONCLUSIONS: The image quality and diagnostic performance achieved with 0.1-mmol/kg gadobenate dimeglumine is at least equivalent to that achieved with 0.2-mmol/kg gadopentetate dimeglumine.

语种: 英语
项目资助者: Bracco Diagnostics Inc
WOS记录号: WOS:000330535300035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63522
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
2.Anhui Prov Hosp, Hefei, Anhui, Peoples R China
3.Shanghai Changhai Hosp, Dept Radiol, Shanghai 200433, Peoples R China
4.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai 200030, Peoples R China
5.Fudan Univ, Dept Radiol, Huashan Hosp, Shanghai 200433, Peoples R China
6.Peking Univ, Dept Radiol, Hosp 1, Beijing 100871, Peoples R China
7.Catholic Univ, Dept Bioimaging & Radiol Sci, Inst Radiol, A Gemelli Hosp, Rome, Italy
8.Univ Milan, Osped San Raffaele, UO Risonanza Magnet, I-20127 Milan, Italy

Recommended Citation:
Li, Yanjun,Li, X.,Li, D.,et al. Multicenter, Intraindividual Comparison of Single-Dose Gadobenate Dimeglumine and Double-Dose Gadopentetate Dimeglumine for MR Angiography of the Supra-Aortic Arteries (the Supra-Aortic VALUE Study)[J]. AMERICAN JOURNAL OF NEURORADIOLOGY,2013,34(4):847-854.
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