IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Implication of ermCX gene of Corynebacterium striatum in macrolide resistance in Beijing, China
Li, Wei; Zhang, Zheng
关键词Antimicrobial resistance Corynebacterium striatum ermCX PCR
刊名BANGLADESH JOURNAL OF PHARMACOLOGY
2013
DOI10.3329/bjp.v8i1.13169
8期:1页:54-57
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]STREPTOCOCCUS-PYOGENES
英文摘要

To study the resistance mechanism of Corynebacterium striatum clinical isolates to macrolide antibiotic, 57 strains of C. striatum clinical isolates were detected by susceptibility testing, PCR amplification and DNA sequencing. The MICs of erythromycin and azithromycin were measured. The Staphylococcus aureus (ATCC 29213) strain was used as control strain for susceptibility testing. A novel pair of specific primers for C. striatum was firstly designed. Out of the 57 strains of C. striatum isolates there were 9 strains of ermCX-carrying isolates screened. The amplified ermCX gene of C. striatum was characterized. High MICs (>= 256 mg/L) of erythromycin and azithromycin was showed in 9 strains which carried ermCX gene. Thus, ermCX gene plays an important role in resistant mechanism of C. striatum in China to macrolide antibiotic. The ermCX gene DNA sequences of two strains (one C. striatum from blood and one C. striatum from pleural fluid) were submitted to GenBank database.

语种英语
WOS记录号WOS:000315282600010
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63524
Collection北京大学第二临床医学院
作者单位Peking Univ, Peoples Hosp, Dept Clin Lab Med, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Li, Wei,Zhang, Zheng. Implication of ermCX gene of Corynebacterium striatum in macrolide resistance in Beijing, China[J]. BANGLADESH JOURNAL OF PHARMACOLOGY,2013,8(1):54-57.
APA Li, Wei,&Zhang, Zheng.(2013).Implication of ermCX gene of Corynebacterium striatum in macrolide resistance in Beijing, China.BANGLADESH JOURNAL OF PHARMACOLOGY,8(1),54-57.
MLA Li, Wei,et al."Implication of ermCX gene of Corynebacterium striatum in macrolide resistance in Beijing, China".BANGLADESH JOURNAL OF PHARMACOLOGY 8.1(2013):54-57.
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