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学科主题: 临床医学
题名:
Implication of ermCX gene of Corynebacterium striatum in macrolide resistance in Beijing, China
作者: Li, Wei; Zhang, Zheng
关键词: Antimicrobial resistance ; Corynebacterium striatum ; ermCX ; PCR
刊名: BANGLADESH JOURNAL OF PHARMACOLOGY
发表日期: 2013
DOI: 10.3329/bjp.v8i1.13169
卷: 8, 期:1, 页:54-57
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: STREPTOCOCCUS-PYOGENES
英文摘要:

To study the resistance mechanism of Corynebacterium striatum clinical isolates to macrolide antibiotic, 57 strains of C. striatum clinical isolates were detected by susceptibility testing, PCR amplification and DNA sequencing. The MICs of erythromycin and azithromycin were measured. The Staphylococcus aureus (ATCC 29213) strain was used as control strain for susceptibility testing. A novel pair of specific primers for C. striatum was firstly designed. Out of the 57 strains of C. striatum isolates there were 9 strains of ermCX-carrying isolates screened. The amplified ermCX gene of C. striatum was characterized. High MICs (>= 256 mg/L) of erythromycin and azithromycin was showed in 9 strains which carried ermCX gene. Thus, ermCX gene plays an important role in resistant mechanism of C. striatum in China to macrolide antibiotic. The ermCX gene DNA sequences of two strains (one C. striatum from blood and one C. striatum from pleural fluid) were submitted to GenBank database.

语种: 英语
WOS记录号: WOS:000315282600010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63524
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Clin Lab Med, Beijing 100044, Peoples R China

Recommended Citation:
Li, Wei,Zhang, Zheng. Implication of ermCX gene of Corynebacterium striatum in macrolide resistance in Beijing, China[J]. BANGLADESH JOURNAL OF PHARMACOLOGY,2013,8(1):54-57.
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