IR@PKUHSC  > 北京大学第二临床医学院  > 心外科
学科主题临床医学
Influence of CYP4F2 genotype on warfarin dose requirement-a systematic review and meta-analysis
Liang, Ruijuan; Wang, Chunling; Zhao, Hong; Huang, Jie; Hu, Dayi; Sun, Yihong
关键词Warfarin CYP4F2 Polymorphisms Genetics Meta-analysis
刊名THROMBOSIS RESEARCH
2012-07-01
DOI10.1016/j.thromres.2011.11.043
130期:1页:38-44
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]AFRICAN-AMERICANS ; ORAL ANTICOAGULATION ; GENETIC-DETERMINANTS ; VKORC1 ; CYP2C9 ; POPULATION ; POLYMORPHISMS ; VARIABILITY ; VARIANTS ; ASSOCIATION
英文摘要

Introduction: Warfarin is a commonly used oral anticoagulant and the dosage is individually adjusted on the basis of the international normalized ratio (INR) monitoring. It is well known that gene polymorphisms of CytochromeP450 (CYP) 2 C9 gene and the vitamin K epoxide reductase complex 1 (VKORC1) were significantly associated with warfarin dose. However, the association between Cytochrome P450 4 F2 (CYP4F2) polymorphism and warfarin dose requirement is still controversial. This study was to investigate the influence of the CYP4F2 polymorphism, V433M (rs2108622) on warfarin dose for patients by meta-analysis.

Methods: Strict inclusion and exclusion criteria were set, and the studies prior to December 19, 2010 were searched in PubMed, EMBASE and CNKI. References were examined and experts of primary studies were consulted for additional information. Revman 5.0.2 software was used to analyze the relationship between warfarin maintenance dose and CYP4F2 polymorphism

Results: Thirteen studies were included in the meta-analysis which consisted of Caucasian, Asian and African populations. Compared to individuals with the homozygous CYP4F2 genotype (CC), carriers of CT, TT genotypes required 10.0% (95% confidence interval(CI) 4.0-15.0) and 21.0% (95% CI 9.0-33.0) higher warfarin doses respectively (P value <0.05). In addition, T carriers required 11.0% (95% CI 6.0-17.0) higher warfarin dose than CC genotype.

Conclusions: Our study showed that polymorphism of CYP4F2 had a moderate but statistically significant association with the variation of interindividual warfarin dose. However, whether CYP4F2 can improve the prediction of warfarin dose warrants need further investigation when combined with environmental factors. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000305267300008
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63527
专题北京大学第二临床医学院_心外科
北京大学第二临床医学院_老年科
作者单位Peking Univ Peoples Hosp, Ctr Heart, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Liang, Ruijuan,Wang, Chunling,Zhao, Hong,et al. Influence of CYP4F2 genotype on warfarin dose requirement-a systematic review and meta-analysis[J]. THROMBOSIS RESEARCH,2012,130(1):38-44.
APA Liang, Ruijuan,Wang, Chunling,Zhao, Hong,Huang, Jie,Hu, Dayi,&Sun, Yihong.(2012).Influence of CYP4F2 genotype on warfarin dose requirement-a systematic review and meta-analysis.THROMBOSIS RESEARCH,130(1),38-44.
MLA Liang, Ruijuan,et al."Influence of CYP4F2 genotype on warfarin dose requirement-a systematic review and meta-analysis".THROMBOSIS RESEARCH 130.1(2012):38-44.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liang, Ruijuan]的文章
[Wang, Chunling]的文章
[Zhao, Hong]的文章
百度学术
百度学术中相似的文章
[Liang, Ruijuan]的文章
[Wang, Chunling]的文章
[Zhao, Hong]的文章
必应学术
必应学术中相似的文章
[Liang, Ruijuan]的文章
[Wang, Chunling]的文章
[Zhao, Hong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。