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学科主题: 临床医学
题名:
Influence of CYP4F2 genotype on warfarin dose requirement-a systematic review and meta-analysis
作者: Liang, Ruijuan; Wang, Chunling; Zhao, Hong; Huang, Jie; Hu, Dayi; Sun, Yihong
关键词: Warfarin ; CYP4F2 ; Polymorphisms ; Genetics ; Meta-analysis
刊名: THROMBOSIS RESEARCH
发表日期: 2012-07-01
DOI: 10.1016/j.thromres.2011.11.043
卷: 130, 期:1, 页:38-44
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: AFRICAN-AMERICANS ; ORAL ANTICOAGULATION ; GENETIC-DETERMINANTS ; VKORC1 ; CYP2C9 ; POPULATION ; POLYMORPHISMS ; VARIABILITY ; VARIANTS ; ASSOCIATION
英文摘要:

Introduction: Warfarin is a commonly used oral anticoagulant and the dosage is individually adjusted on the basis of the international normalized ratio (INR) monitoring. It is well known that gene polymorphisms of CytochromeP450 (CYP) 2 C9 gene and the vitamin K epoxide reductase complex 1 (VKORC1) were significantly associated with warfarin dose. However, the association between Cytochrome P450 4 F2 (CYP4F2) polymorphism and warfarin dose requirement is still controversial. This study was to investigate the influence of the CYP4F2 polymorphism, V433M (rs2108622) on warfarin dose for patients by meta-analysis.

Methods: Strict inclusion and exclusion criteria were set, and the studies prior to December 19, 2010 were searched in PubMed, EMBASE and CNKI. References were examined and experts of primary studies were consulted for additional information. Revman 5.0.2 software was used to analyze the relationship between warfarin maintenance dose and CYP4F2 polymorphism

Results: Thirteen studies were included in the meta-analysis which consisted of Caucasian, Asian and African populations. Compared to individuals with the homozygous CYP4F2 genotype (CC), carriers of CT, TT genotypes required 10.0% (95% confidence interval(CI) 4.0-15.0) and 21.0% (95% CI 9.0-33.0) higher warfarin doses respectively (P value <0.05). In addition, T carriers required 11.0% (95% CI 6.0-17.0) higher warfarin dose than CC genotype.

Conclusions: Our study showed that polymorphism of CYP4F2 had a moderate but statistically significant association with the variation of interindividual warfarin dose. However, whether CYP4F2 can improve the prediction of warfarin dose warrants need further investigation when combined with environmental factors. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000305267300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63527
Appears in Collections:北京大学第二临床医学院_心外科_期刊论文

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作者单位: Peking Univ Peoples Hosp, Ctr Heart, Beijing, Peoples R China

Recommended Citation:
Liang, Ruijuan,Wang, Chunling,Zhao, Hong,et al. Influence of CYP4F2 genotype on warfarin dose requirement-a systematic review and meta-analysis[J]. THROMBOSIS RESEARCH,2012,130(1):38-44.
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