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学科主题: 公共卫生
题名:
The Measurement of Lipids Currently and 9 Years Ago-Which Is More Associated With Carotid Intima-Media Thickness?
作者: Huang, Yubei1; Yu, Xuequn2; Millican, Danielle3; Wu, Liuxin4; Shi, Ping5; Lu, Min6; Wu, Yangfeng1,3
刊名: CLINICAL CARDIOLOGY
发表日期: 2012-08-01
DOI: 10.1002/clc.22015
卷: 35, 期:8, 页:512-517
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: DENSITY-LIPOPROTEIN CHOLESTEROL ; CORONARY-HEART-DISEASE ; POPULATION-BASED ULTRASONOGRAPHY ; CARDIOVASCULAR RISK-FACTORS ; MYOCARDIAL-INFARCTION ; GENERAL-POPULATION ; SERUM-CHOLESTEROL ; CLINICAL-TRIALS ; ARTERY INTIMA ; ATHEROSCLEROSIS
英文摘要:

Background: Massive evidence supports that increase of lipids bring more risk of atherosclerosis. However, it is not clear if lipids measured a long time ago bear more risk than the current measurement. Hypothesis: Lipids measured currently is more associated with carotid atherosclerosis than lipids measured long time ago. Methods: A cohort of 1195 participants age 35 to 64 years was examined in both 19931994 and 2002 for serum lipids, and in 2002 for carotid intima-media thickness (CIMT) with B mode ultrasound. The associations of lipids at baseline and at reexamination with CIMT were analyzed and compared using multiple linear regressions. Results: All lipid variables, except for high-density lipoprotein cholesterol (HDL-C) both at baseline and reexamination, were significantly associated with age-adjusted CIMT in both males and females (all Ptrend <0.01). The age-adjusted mean of CIMT in all of the population was 0.696 mm in those having low low-density lipoprotein cholesterol (LDL-C) at both examinations, 0.719 mm in those having high LDL-C only at baseline, 0.706 mm in those having high LDL-C only at reexamination, and 0.727 mm in those having high LDL-C at both examinations. Further analysis showed that lipids measured at baseline remained significant, whereas lipids at reexamination became not significant in all models, except those for HDL-C and total cholesterol (TC)/HDL-C, which allow the lipids at different times to compete in association with CIMT. Conclusions: Both the current measurement of lipids (TC, LDL-C, non-HDL-C, TC/HDL-C, and LDL-C/HDL-C) and the measurement from 9 years ago are significantly associated with CIMT, but the measurement from 9 years ago had an even stronger association. Clin. Cardiol. 2012 doi: 10.1002/clc.22015 Additional Supporting Information may be found in the online version of this article. The authors have no funding, financial relationships, or conflicts of interest to disclose.

语种: 英语
WOS记录号: WOS:000307116500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63543
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Shijingshan Dist Ctr Dis Control, Beijing, Peoples R China
2.Beijing Municipal Ctr Dis Control, Beijing, Peoples R China
3.Int Ctr Alcohol Policies, Beijing, Peoples R China
4.George Inst Global Hlth, Beijing, Peoples R China
5.Inst Aeromed AF, Beijing, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China

Recommended Citation:
Huang, Yubei,Yu, Xuequn,Millican, Danielle,et al. The Measurement of Lipids Currently and 9 Years Ago-Which Is More Associated With Carotid Intima-Media Thickness?[J]. CLINICAL CARDIOLOGY,2012,35(8):512-517.
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