IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Preclinical evaluation of a two-dose vaccination schedule of recombinant Hansenula polymorpha hepatitis B vaccine in animals
Li, Jin1,2,3; Zhang, Deyou3; Ma, Rui3; Yang, Xuqin3; Wang, Xi3; Li, Caimei3; Zhang, Sucai4; Xue, Hesheng5; Zhao, Kai6; Zhuang, Hui1,2
关键词hepatitis B Vaccine 2-dose regimen Hansenula Polymorpha-derived vaccine Cynomolgus monkey
刊名HUMAN VACCINES & IMMUNOTHERAPEUTICS
2013-04-01
DOI10.4161/hv.23227
9期:4页:736-743
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Immunology
研究领域[WOS]Biotechnology & Applied Microbiology ; Immunology
关键词[WOS]SURFACE-ANTIGEN VACCINE ; RANDOMIZED-TRIAL ; VIRUS-INFECTION ; HOMOSEXUAL-MEN ; EFFICACY TRIAL ; FOLLOW-UP ; CHINA ; YEAST ; IMMUNOGENICITY ; DISEASE
英文摘要

Aims: The current 3-dose regimen of hepatitis B vaccination for infants requiring over 6 mo period may pose the poor rate of compliance and later protection from hepatitis B virus (HBV) infection. This preclinical study is to investigate the feasibility of reducing the number of doses of hepatitis B (HB) vaccine. Results:Eight groups of guinea pigs immunized with two doses of HP-HB vaccines at either 0 and 4 weeks or 0 and 8 weeks elicited geometric titers (GMT) of anti-HBs similar to that of four groups immunized with three doses of controls. The overall GMT of anti-HBs were not significantly different between the E- and C-groups (p > 0.05) of monkeys. Specifically, the anti-HBs titers in the C-group reached the peak of 24857 (938.3-104585) mIU/mL one week after the 3rd dose, which were statistically higher than those of the E-group. However, they were reduced to comparable levels of anti-HBs in the E-group during weeks 9-12, suggesting comparable immune response of both vaccination regimens. Methods:Twelve groups of guinea pigs (four animals in each group) were immunized with 2 experimental recombinant yeast Hansenula Polymorpha derived HB vaccines (HP-HB vaccine) and 2 commercial recombinant yeast Saccharomyces Cerevisiae vaccines (Temrevac-HB) as controls at 0, 4 and 8 weeks, 0 and 4 weeks, and 0 and 8 weeks respectively. Each guinea pig received 2 mu g vaccine. Twelve Cynomolgus monkeys were randomly divided into two groups (six animals in each group). Animals in the experimental group (E-group) were injected with two doses of pilot produced 20 mu g HP-HB vaccine. Animals in the control group (C-Group) were immunized with three doses of 10 mu g Temrevac-HB. Both vaccines were administered at an interval of 3 weeks for monkeys. Conclusions:The 2-dose regimen of the HP-HB vaccine has comparable HBV immune responses as the 3-dose regimen of Temrevac-HB vaccine in Cynomolgus monkeys.

语种英语
WOS记录号WOS:000327549500012
项目编号2008ZX10002-002 ; 2012ZX10002002-002
资助机构National Projects on the Control of Major Infectious Diseases
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63546
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Infect Dis, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100871, Peoples R China
3.Joinn Labs, Beijing, Peoples R China
4.Natl Vaccine & Serum Inst, Beijing, Peoples R China
5.Beijing Tiantan Biol Prod Co Ltd, Vaccine Res Dept 2, Beijing, Peoples R China
6.Chinese Ctr Dis Control & Prevent China CDC, Ctr Publ Hlth Surveillance & Informat Serv, Beijing, Peoples R China
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GB/T 7714
Li, Jin,Zhang, Deyou,Ma, Rui,et al. Preclinical evaluation of a two-dose vaccination schedule of recombinant Hansenula polymorpha hepatitis B vaccine in animals[J]. HUMAN VACCINES & IMMUNOTHERAPEUTICS,2013,9(4):736-743.
APA Li, Jin.,Zhang, Deyou.,Ma, Rui.,Yang, Xuqin.,Wang, Xi.,...&Zhuang, Hui.(2013).Preclinical evaluation of a two-dose vaccination schedule of recombinant Hansenula polymorpha hepatitis B vaccine in animals.HUMAN VACCINES & IMMUNOTHERAPEUTICS,9(4),736-743.
MLA Li, Jin,et al."Preclinical evaluation of a two-dose vaccination schedule of recombinant Hansenula polymorpha hepatitis B vaccine in animals".HUMAN VACCINES & IMMUNOTHERAPEUTICS 9.4(2013):736-743.
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