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学科主题: 基础医学
题名:
Preclinical evaluation of a two-dose vaccination schedule of recombinant Hansenula polymorpha hepatitis B vaccine in animals
作者: Li, Jin1,2,3; Zhang, Deyou3; Ma, Rui3; Yang, Xuqin3; Wang, Xi3; Li, Caimei3; Zhang, Sucai4; Xue, Hesheng5; Zhao, Kai6; Zhuang, Hui1,2
关键词: hepatitis B ; Vaccine ; 2-dose regimen ; Hansenula Polymorpha-derived vaccine ; Cynomolgus monkey
刊名: HUMAN VACCINES & IMMUNOTHERAPEUTICS
发表日期: 2013-04-01
DOI: 10.4161/hv.23227
卷: 9, 期:4, 页:736-743
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Immunology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Immunology
关键词[WOS]: SURFACE-ANTIGEN VACCINE ; RANDOMIZED-TRIAL ; VIRUS-INFECTION ; HOMOSEXUAL-MEN ; EFFICACY TRIAL ; FOLLOW-UP ; CHINA ; YEAST ; IMMUNOGENICITY ; DISEASE
英文摘要:

Aims: The current 3-dose regimen of hepatitis B vaccination for infants requiring over 6 mo period may pose the poor rate of compliance and later protection from hepatitis B virus (HBV) infection. This preclinical study is to investigate the feasibility of reducing the number of doses of hepatitis B (HB) vaccine. Results:Eight groups of guinea pigs immunized with two doses of HP-HB vaccines at either 0 and 4 weeks or 0 and 8 weeks elicited geometric titers (GMT) of anti-HBs similar to that of four groups immunized with three doses of controls. The overall GMT of anti-HBs were not significantly different between the E- and C-groups (p > 0.05) of monkeys. Specifically, the anti-HBs titers in the C-group reached the peak of 24857 (938.3-104585) mIU/mL one week after the 3rd dose, which were statistically higher than those of the E-group. However, they were reduced to comparable levels of anti-HBs in the E-group during weeks 9-12, suggesting comparable immune response of both vaccination regimens. Methods:Twelve groups of guinea pigs (four animals in each group) were immunized with 2 experimental recombinant yeast Hansenula Polymorpha derived HB vaccines (HP-HB vaccine) and 2 commercial recombinant yeast Saccharomyces Cerevisiae vaccines (Temrevac-HB) as controls at 0, 4 and 8 weeks, 0 and 4 weeks, and 0 and 8 weeks respectively. Each guinea pig received 2 mu g vaccine. Twelve Cynomolgus monkeys were randomly divided into two groups (six animals in each group). Animals in the experimental group (E-group) were injected with two doses of pilot produced 20 mu g HP-HB vaccine. Animals in the control group (C-Group) were immunized with three doses of 10 mu g Temrevac-HB. Both vaccines were administered at an interval of 3 weeks for monkeys. Conclusions:The 2-dose regimen of the HP-HB vaccine has comparable HBV immune responses as the 3-dose regimen of Temrevac-HB vaccine in Cynomolgus monkeys.

语种: 英语
所属项目编号: 2008ZX10002-002 ; 2012ZX10002002-002
项目资助者: National Projects on the Control of Major Infectious Diseases
WOS记录号: WOS:000327549500012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63546
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Infect Dis, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100871, Peoples R China
3.Joinn Labs, Beijing, Peoples R China
4.Natl Vaccine & Serum Inst, Beijing, Peoples R China
5.Beijing Tiantan Biol Prod Co Ltd, Vaccine Res Dept 2, Beijing, Peoples R China
6.Chinese Ctr Dis Control & Prevent China CDC, Ctr Publ Hlth Surveillance & Informat Serv, Beijing, Peoples R China

Recommended Citation:
Li, Jin,Zhang, Deyou,Ma, Rui,et al. Preclinical evaluation of a two-dose vaccination schedule of recombinant Hansenula polymorpha hepatitis B vaccine in animals[J]. HUMAN VACCINES & IMMUNOTHERAPEUTICS,2013,9(4):736-743.
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