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学科主题: 基础医学
题名:
Immunoglobulin mRNA and protein expression in human oral epithelial tumor cells
作者: Zhu, Xiaohui1; Li, Cuiying2; Sun, Xin1; Mao, Yuntao1; Li, Guohui1; Litt, Xiaoyong2; Zhang, Youhui3,4; Qiu, Xiaoyan1
关键词: immunoglobulin ; expression ; V(D)J rearrangement ; oral ; epithelial tumor
刊名: APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
发表日期: 2008-05-01
卷: 16, 期:3, 页:232-238
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
研究领域[WOS]: Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
关键词[WOS]: CHAIN CONSTANT-REGION ; BREAST-CANCER ; PATIENT ; PLASMA ; LINES
英文摘要:

In our previous work, we have reported the expression of immunoglobulin (Ig) molecules by numerous epithelial cancer cells and hyperplastic epithelial cells. In the present study, we extended our investigation to study the frequencies of expression of IgG and IgA in some types of oral epithelial tumor cells, and analyzed the oral tumor-derived V regions characteristic of Ig gamma chain gene transcripts by immunohistochemistry, in situ hybridization, laser capture microdissection-correlated reverse-transcription polymerase chain reaction, and sequencing. IgG and IgA immunoreactivity was prominent in the cytoplasmic or plasma membrane or secretion of malignant cells, pleomorphic adenoma tumor cells, and some normal glandular epithelial cells or squamous cells adjacent to tumors. More importantly, rearranged Ig gene transcripts were identified in these tumor cells, and in some normal glandular epithelial cells, the V-DJ region sequences revealed that IgG transcripts in 2 tested oral tumors were oligoclonal. These results support that the phenomenon of Ig could also be expressed in oral cavity epithelial tumor cells.

语种: 英语
WOS记录号: WOS:000255692800005
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63553
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
2.Capital Univ Med Sci, Beijing Stomatol Hosp, Dept Pathol, Beijing, Peoples R China
3.Chinese Acad Med Sci, Dept Immunol, Inst Canc, Beijing 100037, Peoples R China
4.Peking Union Med Coll, Beijing 100021, Peoples R China

Recommended Citation:
Zhu, Xiaohui,Li, Cuiying,Sun, Xin,et al. Immunoglobulin mRNA and protein expression in human oral epithelial tumor cells[J]. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY,2008,16(3):232-238.
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