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Analytical strategy to reveal the in vivo process of multi-component herbal medicine: A pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry
Qiao, Xue; Ye, Min; Xiang, Cheng; Wang, Qing; Liu, Chun-fang; Miao, Wen-juan; Guo, De-an
关键词Multi-component pharmacokinetics Herbal medicine LC/MS/MS Licorice Glycyrrhiza uralensis Fisch
刊名JOURNAL OF CHROMATOGRAPHY A
2012-10-05
DOI10.1016/j.chroma.2012.08.041
1258页:84-93
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]ORIENTAL PLANT DRUGS ; GLYCYRRHIZAE-RADIX ; TRITERPENE OLIGOGLYCOSIDES ; RAT PLASMA ; CANCER ; ROOT ; ACID ; TRANSPORTERS ; PHARMACOLOGY ; METABOLITES
英文摘要

Although various techniques have been employed to analyze drug metabolites, the metabolism of multicomponent herbal medicine has seldom been fully addressed. In contrast to chemical drugs, a number of compounds in herbal medicine could get into circulation and then be metabolized. Moreover, these compounds may have metabolic interactions which make their pharmacokinetics (PK) even more complicated. The present work aims to elucidate the multi-component pharmacokinetics of a herbal medicine, and to demonstrate how PK behaviors were altered by co-existing constituents. Licorice (Glycyrrhiza uralensis Fisch.), a most commonly used herbal medicine, was chosen as a model. A strategy was proposed to compare the PK profiles of licorice extract with those of nine single compounds. These compounds were major bioactive constituents of licorice, and represented various structural types (flavanone, chalcone, isoflavone, saponin, and coumarin). We established a segmented selected reaction monitoring LC/MS/MS method to simultaneously monitor 63 licorice metabolites in rat plasma, and obtained the PK profiles of 55 metabolites. The results indicated that interactions among licorice compounds altered their PK behaviors in 4 aspects: improvement in bioavailability for aglycones (133- and 109-fold increase for liquiritigenin and isoliquiritigenin, respectively), prolongation in system circulation for glycosides (0.3 h delay in T-max for liquiritin apioside and isoliquiritin apioside), decrease of potential toxicity for saponins such as glycyrrhizic acid, and shift in plasma distribution for phase II metabolites. This is the first attempt to systematically reveal the in vivo process of licorice. Moreover, the study indicates noticeable interactions to alter pharmacokinetics among licorice compounds, which may be characteristic for herbal medicines. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000309294200010
项目编号81173644 ; BMU20110269
资助机构National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from China Ministry of Education ; Scholarship for Excellent Doctoral Students from China Ministry of Education
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63556
专题北京大学药学院
北京大学药学院_天然药物学系
北京大学精神卫生研究所_药房
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Qiao, Xue,Ye, Min,Xiang, Cheng,et al. Analytical strategy to reveal the in vivo process of multi-component herbal medicine: A pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2012,1258:84-93.
APA Qiao, Xue.,Ye, Min.,Xiang, Cheng.,Wang, Qing.,Liu, Chun-fang.,...&Guo, De-an.(2012).Analytical strategy to reveal the in vivo process of multi-component herbal medicine: A pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry.JOURNAL OF CHROMATOGRAPHY A,1258,84-93.
MLA Qiao, Xue,et al."Analytical strategy to reveal the in vivo process of multi-component herbal medicine: A pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry".JOURNAL OF CHROMATOGRAPHY A 1258(2012):84-93.
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