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学科主题: 药学
题名:
Analytical strategy to reveal the in vivo process of multi-component herbal medicine: A pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry
作者: Qiao, Xue; Ye, Min; Xiang, Cheng; Wang, Qing; Liu, Chun-fang; Miao, Wen-juan; Guo, De-an
关键词: Multi-component pharmacokinetics ; Herbal medicine ; LC/MS/MS ; Licorice ; Glycyrrhiza uralensis Fisch
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2012-10-05
DOI: 10.1016/j.chroma.2012.08.041
卷: 1258, 页:84-93
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: ORIENTAL PLANT DRUGS ; GLYCYRRHIZAE-RADIX ; TRITERPENE OLIGOGLYCOSIDES ; RAT PLASMA ; CANCER ; ROOT ; ACID ; TRANSPORTERS ; PHARMACOLOGY ; METABOLITES
英文摘要:

Although various techniques have been employed to analyze drug metabolites, the metabolism of multicomponent herbal medicine has seldom been fully addressed. In contrast to chemical drugs, a number of compounds in herbal medicine could get into circulation and then be metabolized. Moreover, these compounds may have metabolic interactions which make their pharmacokinetics (PK) even more complicated. The present work aims to elucidate the multi-component pharmacokinetics of a herbal medicine, and to demonstrate how PK behaviors were altered by co-existing constituents. Licorice (Glycyrrhiza uralensis Fisch.), a most commonly used herbal medicine, was chosen as a model. A strategy was proposed to compare the PK profiles of licorice extract with those of nine single compounds. These compounds were major bioactive constituents of licorice, and represented various structural types (flavanone, chalcone, isoflavone, saponin, and coumarin). We established a segmented selected reaction monitoring LC/MS/MS method to simultaneously monitor 63 licorice metabolites in rat plasma, and obtained the PK profiles of 55 metabolites. The results indicated that interactions among licorice compounds altered their PK behaviors in 4 aspects: improvement in bioavailability for aglycones (133- and 109-fold increase for liquiritigenin and isoliquiritigenin, respectively), prolongation in system circulation for glycosides (0.3 h delay in T-max for liquiritin apioside and isoliquiritin apioside), decrease of potential toxicity for saponins such as glycyrrhizic acid, and shift in plasma distribution for phase II metabolites. This is the first attempt to systematically reveal the in vivo process of licorice. Moreover, the study indicates noticeable interactions to alter pharmacokinetics among licorice compounds, which may be characteristic for herbal medicines. (C) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81173644 ; BMU20110269
项目资助者: National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from China Ministry of Education ; Scholarship for Excellent Doctoral Students from China Ministry of Education
WOS记录号: WOS:000309294200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63556
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Qiao, Xue,Ye, Min,Xiang, Cheng,et al. Analytical strategy to reveal the in vivo process of multi-component herbal medicine: A pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2012,1258:84-93.
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