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学科主题: 药学
题名:
Studies on the large scale synthesis and anti-tumor activity of YSL
作者: Wang, C; Ding, WF; Zhao, M; Lin, G; Peng, SQ
关键词: YSL ; synthesis ; anti-tumor activity ; large scale
刊名: PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
发表日期: 2003
DOI: 10.1081/PB-120022987
卷: 33, 期:3, 页:189-195
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
关键词[WOS]: PEPTIDE
英文摘要:

H-Tyr-Ser-Leu-OH (YSL), isolated from the degradation products of porcine spleen, was synthesized by a solution method on a large scale via two synthetic strategies. Its structure was confirmed by spectroscopic and related analyses. The in vivo anti-tumor activity was evaluated with murine H22 tumor models. The result indicated that, with the administration of YSL, the survival time of the murine H22 implanted mice was significantly prolonged.

语种: 英语
WOS记录号: WOS:000184533200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63562
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, C,Ding, WF,Zhao, M,et al. Studies on the large scale synthesis and anti-tumor activity of YSL[J]. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY,2003,33(3):189-195.
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