IR@PKUHSC  > 北京大学第三临床医学院  > 泌尿外科
学科主题临床医学
Osthole Ameliorates Renal Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response
Zheng, Yi1; Lu, Min2; Ma, Lulin1; Zhang, Shudong1; Qiu, Min1; Ma, Xin3
关键词Cytokine Inflammation Ischemia-reperfusion Kidney Osthole
刊名UROLOGIA INTERNATIONALIS
2013
DOI10.1159/000347191
91期:3页:350-356
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
研究领域[WOS]Urology & Nephrology
关键词[WOS]ISCHEMIA/REPERFUSION INJURY ; EXPRESSION ; FAILURE ; KIDNEY ; MICE ; ACTIVATION ; PROTECTION ; COMPOUND ; STRESS ; CELLS
英文摘要

Introduction: Renal ischemia-reperfusion (I/R) injury is a primary cause of acute renal failure that results in high mortality. This study aimed to investigate the effect of osthole, a natural coumarin derivative, on renal I/R injury in a rat model. Materials and Methods: Rats were randomly allocated to the sham operation + vehicle, I/R + vehicle, and I/R + osthole groups. Renal I/R injury was induced by clamping the left renal artery for 45 min followed by 12 h of reperfusion and a contralateral nephrectomy. Osthole (40 mg/kg) was intraperitoneally injected 30 min before inducing I/R. Renal function and histological damage were determined subsequently. Myeloperoxidase activity, monocyte/macrophage infiltration, as well as tumor necrosis factor-alpha, IL-1 beta, and activated p38 mitogen-activated protein kinase expression in kidneys were also assessed. Results: Osthole treatment significantly ameliorated I/R-induced renal functional and morphological injuries. Moreover, osthole treatment attenuated myeloperoxidase activity, monocyte/macrophage infiltration, and tumor necrosis factor-alpha, IL-1 beta, and activated p38 mitogen-activated protein kinase expression in kidneys. Conclusions: Osthole treatment ameliorates renal I/R injury by inhibiting inflammatory responses in kidneys. Thus, osthole may represent a novel practical strategy to prevent renal I/R injury. Copyright (C) 2013 S. Karger AG, Basel

语种英语
所属项目编号30950018 ; 7113174
资助者National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号WOS:000325832600019
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63567
Collection北京大学第三临床医学院_泌尿外科
作者单位1.Peking Univ, Hosp 3, Dept Urol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China
3.Beijing Univ Chinese Med, Sch Basic Med Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Yi,Lu, Min,Ma, Lulin,et al. Osthole Ameliorates Renal Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response[J]. UROLOGIA INTERNATIONALIS,2013,91(3):350-356.
APA Zheng, Yi,Lu, Min,Ma, Lulin,Zhang, Shudong,Qiu, Min,&Ma, Xin.(2013).Osthole Ameliorates Renal Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response.UROLOGIA INTERNATIONALIS,91(3),350-356.
MLA Zheng, Yi,et al."Osthole Ameliorates Renal Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response".UROLOGIA INTERNATIONALIS 91.3(2013):350-356.
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