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学科主题: 临床医学
题名:
Osthole Ameliorates Renal Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response
作者: Zheng, Yi1; Lu, Min2; Ma, Lulin1; Zhang, Shudong1; Qiu, Min1; Ma, Xin3
关键词: Cytokine ; Inflammation ; Ischemia-reperfusion ; Kidney ; Osthole
刊名: UROLOGIA INTERNATIONALIS
发表日期: 2013
DOI: 10.1159/000347191
卷: 91, 期:3, 页:350-356
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ISCHEMIA/REPERFUSION INJURY ; EXPRESSION ; FAILURE ; KIDNEY ; MICE ; ACTIVATION ; PROTECTION ; COMPOUND ; STRESS ; CELLS
英文摘要:

Introduction: Renal ischemia-reperfusion (I/R) injury is a primary cause of acute renal failure that results in high mortality. This study aimed to investigate the effect of osthole, a natural coumarin derivative, on renal I/R injury in a rat model. Materials and Methods: Rats were randomly allocated to the sham operation + vehicle, I/R + vehicle, and I/R + osthole groups. Renal I/R injury was induced by clamping the left renal artery for 45 min followed by 12 h of reperfusion and a contralateral nephrectomy. Osthole (40 mg/kg) was intraperitoneally injected 30 min before inducing I/R. Renal function and histological damage were determined subsequently. Myeloperoxidase activity, monocyte/macrophage infiltration, as well as tumor necrosis factor-alpha, IL-1 beta, and activated p38 mitogen-activated protein kinase expression in kidneys were also assessed. Results: Osthole treatment significantly ameliorated I/R-induced renal functional and morphological injuries. Moreover, osthole treatment attenuated myeloperoxidase activity, monocyte/macrophage infiltration, and tumor necrosis factor-alpha, IL-1 beta, and activated p38 mitogen-activated protein kinase expression in kidneys. Conclusions: Osthole treatment ameliorates renal I/R injury by inhibiting inflammatory responses in kidneys. Thus, osthole may represent a novel practical strategy to prevent renal I/R injury. Copyright (C) 2013 S. Karger AG, Basel

语种: 英语
所属项目编号: 30950018 ; 7113174
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000325832600019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63567
Appears in Collections:北京大学第三临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Urol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China
3.Beijing Univ Chinese Med, Sch Basic Med Sci, Beijing, Peoples R China

Recommended Citation:
Zheng, Yi,Lu, Min,Ma, Lulin,et al. Osthole Ameliorates Renal Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response[J]. UROLOGIA INTERNATIONALIS,2013,91(3):350-356.
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