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学科主题: 基础医学
题名:
IQGAP3 Promotes EGFR-ERK Signaling and the Growth and Metastasis of Lung Cancer Cells
作者: Yang, Ying; Zhao, Wei; Xu, Qing-Wen; Wang, Xiao-Song; Zhang, Yu; Zhang, Jun
刊名: PLOS ONE
发表日期: 2014-05-21
DOI: 10.1371/journal.pone.0097578
卷: 9, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: TYROSINE KINASE ; HUMAN-BREAST ; COPY NUMBER ; RECEPTOR ; THERAPY ; TARGETS ; CALMODULIN ; EXPRESSION ; CARCINOMA ; PROTEINS
英文摘要:

Proteins of the IQGAP family display complicated and often contradictory activities in tumorigenesis. IQGAP1 has well documented oncogenic potential and IQGAP2 has putative tumor-suppressive function. IQGAP3 is the latest addition to this family and its role in cancer development remains to be defined. Here we demonstrate IQGAP3 expression is markedly increased in lung cancer tissues at both mRNA and protein levels. Overexpression of IQGAP3 promoted tumor cell growth, and migration and invasion, whereas knockdown of IQGAP3 exhibited opposite effects. Moreover, suppression of IQGAP3 in a lung cancer cell line caused a reduction in the tumorigenicity of these cells in lung tissue after intravenous injection. Furthermore, we showed that IQGAP3 is able to interact with ERK1 and enhance its phosphorylation following treatment with EGF. These data suggest that IQGAP3 may contribute to the pathogenesis of lung cancer by modulating EGFR-ERK signaling.

语种: 英语
所属项目编号: 2011CB946103 ; 31330025 ; 30830091 ; 7122104 ; B07001
项目资助者: National Basic Research Program of China ; National Natural Sciences Foundation of China ; Beijing Municipal Natural Science Foundation ; 111 Project of China
WOS记录号: WOS:000336730600038
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63571
Appears in Collections:基础医学院_免疫学系_期刊论文

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10.1371-journal.pone.0097578.PDF(3580KB)期刊论文出版稿限制开放 联系获取全文

作者单位: Peking Univ, Hlth Sci Ctr, Dept Immunol, Sch Basic Med Sci,Key Lab Med Immunol,Minist Publ, Beijing 100871, Peoples R China

Recommended Citation:
Yang, Ying,Zhao, Wei,Xu, Qing-Wen,et al. IQGAP3 Promotes EGFR-ERK Signaling and the Growth and Metastasis of Lung Cancer Cells[J]. PLOS ONE,2014,9(5).
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