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Design and characterization of Amoitone B-loaded nanostructured lipid carriers for controlled drug release
Luan, Jingjing1; Zhang, Dianrui1; Hao, Leilei1; Li, Caiyun1; Qi, Lisi1; Guo, Hejian1; Liu, Xinquan1; Zhang, Qiang2
关键词Amoitone B (AmB) drug entrapment efficacy (EE) in vitro release nanostructured lipid carriers (NLC) various amounts of liquid lipid
刊名DRUG DELIVERY
2013-11-01
DOI10.3109/10717544.2013.835007
20期:8页:324-330
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]SOLVENT DIFFUSION METHOD ; ORPHAN-RECEPTOR NUR77 ; CANCER CELLS ; IN-VITRO ; NANOPARTICLES SLN ; AQUEOUS SYSTEM ; APOPTOSIS ; DELIVERY ; PHARMACOKINETICS ; LIQUID
英文摘要

Amoitone B, a novel compound chemically synthesized as the analogue of cytosporone B, has been proved to own superior affinity with Nur77 than its parent compound and exhibit notable anticancer activity. However, its application is seriously restricted due to the water-insolubility and short biological half-time. The aim of this study was to construct an effective delivery system for Amoitone B to realize sustained release, thus prolong drug circulation time in body and improve the bioavailability. Nanostructured lipid carriers (NLC) act as a new type of colloidal drug delivery system, which offer the advantages of improved drug loading and sustained release. Amoitone B-loaded NLC (AmB-NLC) containing glyceryl monostearate (GMS) and various amounts of medium chain triglycerides (MCT) were successfully prepared by emulsion-evaporation and low temperature-solidification technology with a particle size of about 200 nm and a zeta potential value of about -20 mV. The results of X-ray diffraction and DSC analysis showed amorphous crystalline state of Amoitone B in NLC. Furthermore, the drug entrapment efficacy (EE) was improved compared with solid lipid nanoparticles (SLN). The EE range was from 71.1% to 84.7%, enhanced with the increase of liquid lipid. In vitro drug release studies revealed biphasic drug release patterns with burst release initially and prolonged release afterwards and the release was accelerated with augment of liquid lipid. These results demonstrated that AmB-NLC could be a promising delivery system to control drug release and improve loading capacity, thus prolong drug action time in body and enhance the bioavailability.

语种英语
WOS记录号WOS:000325713200003
项目编号2009CB930300
资助机构National Basic Research Program of China (973 Program)
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63577
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
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GB/T 7714
Luan, Jingjing,Zhang, Dianrui,Hao, Leilei,et al. Design and characterization of Amoitone B-loaded nanostructured lipid carriers for controlled drug release[J]. DRUG DELIVERY,2013,20(8):324-330.
APA Luan, Jingjing.,Zhang, Dianrui.,Hao, Leilei.,Li, Caiyun.,Qi, Lisi.,...&Zhang, Qiang.(2013).Design and characterization of Amoitone B-loaded nanostructured lipid carriers for controlled drug release.DRUG DELIVERY,20(8),324-330.
MLA Luan, Jingjing,et al."Design and characterization of Amoitone B-loaded nanostructured lipid carriers for controlled drug release".DRUG DELIVERY 20.8(2013):324-330.
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