|Antipsychotic polypharmacy in schizophrenia patients in China and its association with treatment satisfaction and quality of life: Findings of the third national survey on use of psychotropic medications in China|
|Li, Qian1,2; Xiang, Yu-Tao3; Su, Yun-Ai1,2; Shu, Liang1,2; Yu, Xin1,2; Chiu, Helen F. K.4; Correll, Christoph U.5; Ungvari, Gabor S.6; Lai, Kelly Y. C.4; Ma, Cui7; Wang, Gao-Hua8; Bai, Pei-Shen9; Li, Tao10; Sun, Li-Zhong11; Shi, Jian-Guo12; Chen, Xian-Sheng13; Mei, Qi-Yi14; Li, Ke-Qing15; Si, Tian-Mei1,2|
|关键词||Antipsychotic polypharmacy prescription patterns schizophrenia|
|刊名||AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY|
|收录类别||SCI ; SSCI|
|WOS标题词||Science & Technology|
|关键词[WOS]||ATYPICAL ANTIPSYCHOTICS ; SOCIAL DETERMINANTS ; EAST-ASIA ; PREDICTORS ; MONOTHERAPY ; PREVALENCE ; BENZODIAZEPINES ; TOLERABILITY ; PRESCRIPTION ; METAANALYSIS|
Objective: This study examined the use, demographic and clinical correlates of antipsychotic polypharmacy (APP) and its associations with treatment satisfaction and quality of life (QOL) in schizophrenia patients in China.
Method: A total of 4239 patients in 45 nationwide Chinese psychiatric hospitals/centers were interviewed in 2012 in the third cross-sectional study, with the first two having been conducted in 2002 and 2006. Patients′ socio-demographic and clinical characteristics, including psychopathology, side effects, satisfaction with treatment and QOL, were recorded using a standardized protocol and data collection procedure.
Results: The proportion of APP prescriptions in 2012 was 34.2%, which was significantly higher than the frequency of APP in 2002 (26.1%) and 2006 (26.4%) (p<0.001). Of patients on APP, 91.1% received two antipsychotics, 8.6% received three and 0.3% received four or more antipsychotics. Multiple logistic regression analyses revealed that compared to those on antipsychotic monotherapy, patients on APP and their families had lower satisfaction with treatment, had higher QOL in the mental domain, younger age of onset, more side effects, higher doses of antipsychotics and were more likely to receive first-generation antipsychotics and less likely to receive benzodiazepines (total R-2=0.31, p<0.001).
Conclusions: APP was found in about one in three schizophrenia patients. The prevalence of APP seems to have been increasing since 2002. Considering the increased frequency of drug-induced side effects and the patients′ and their relatives′ dissatisfaction with antipsychotic treatment, further examination of the rationale and appropriateness of APP and its alternatives is warranted.
|资助机构||12th Five-Year Plan of the National Key Technologies R& ; D Program of China|
|作者单位||1.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China|
2.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
3.Univ Macau, Fac Hlth Sci, Macau, Macao, Peoples R China
4.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
5.North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
6.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
7.Hosp Psychiat, Guangzhou, Guangdong, Peoples R China
8.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430072, Peoples R China
9.Shanxi Med Univ, Hosp 1, Taiyuan, Shanxi Province, Peoples R China
10.Sichuan Univ, West China Hosp, Chengdu, Peoples R China
11.Neuropsychiat Hosp, Changchun, Jilin, Peoples R China
12.Mental Hlth Ctr, Xian, Peoples R China
13.Jiangxi Psychiat Hosp, Nanchang, Jiangxi, Peoples R China
14.Suzhou Guangji Hosp, Suzhou, Peoples R China
15.Hebei Mental Hlth Ctr, Baoding, Hebei, Peoples R China
|Li, Qian,Xiang, Yu-Tao,Su, Yun-Ai,et al. Antipsychotic polypharmacy in schizophrenia patients in China and its association with treatment satisfaction and quality of life: Findings of the third national survey on use of psychotropic medications in China[J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,2015,49(2):129-136.|
|APA||Li, Qian.,Xiang, Yu-Tao.,Su, Yun-Ai.,Shu, Liang.,Yu, Xin.,...&Si, Tian-Mei.(2015).Antipsychotic polypharmacy in schizophrenia patients in China and its association with treatment satisfaction and quality of life: Findings of the third national survey on use of psychotropic medications in China.AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,49(2),129-136.|
|MLA||Li, Qian,et al."Antipsychotic polypharmacy in schizophrenia patients in China and its association with treatment satisfaction and quality of life: Findings of the third national survey on use of psychotropic medications in China".AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY 49.2(2015):129-136.|