IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Antipsychotic polypharmacy in schizophrenia patients in China and its association with treatment satisfaction and quality of life: Findings of the third national survey on use of psychotropic medications in China
Li, Qian1,2; Xiang, Yu-Tao3; Su, Yun-Ai1,2; Shu, Liang1,2; Yu, Xin1,2; Chiu, Helen F. K.4; Correll, Christoph U.5; Ungvari, Gabor S.6; Lai, Kelly Y. C.4; Ma, Cui7; Wang, Gao-Hua8; Bai, Pei-Shen9; Li, Tao10; Sun, Li-Zhong11; Shi, Jian-Guo12; Chen, Xian-Sheng13; Mei, Qi-Yi14; Li, Ke-Qing15; Si, Tian-Mei1,2
关键词Antipsychotic polypharmacy prescription patterns schizophrenia
刊名AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
2015-02-01
DOI10.1177/0004867414536931
49期:2页:129-136
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]ATYPICAL ANTIPSYCHOTICS ; SOCIAL DETERMINANTS ; EAST-ASIA ; PREDICTORS ; MONOTHERAPY ; PREVALENCE ; BENZODIAZEPINES ; TOLERABILITY ; PRESCRIPTION ; METAANALYSIS
英文摘要

Objective: This study examined the use, demographic and clinical correlates of antipsychotic polypharmacy (APP) and its associations with treatment satisfaction and quality of life (QOL) in schizophrenia patients in China.

Method: A total of 4239 patients in 45 nationwide Chinese psychiatric hospitals/centers were interviewed in 2012 in the third cross-sectional study, with the first two having been conducted in 2002 and 2006. Patients′ socio-demographic and clinical characteristics, including psychopathology, side effects, satisfaction with treatment and QOL, were recorded using a standardized protocol and data collection procedure.

Results: The proportion of APP prescriptions in 2012 was 34.2%, which was significantly higher than the frequency of APP in 2002 (26.1%) and 2006 (26.4%) (p<0.001). Of patients on APP, 91.1% received two antipsychotics, 8.6% received three and 0.3% received four or more antipsychotics. Multiple logistic regression analyses revealed that compared to those on antipsychotic monotherapy, patients on APP and their families had lower satisfaction with treatment, had higher QOL in the mental domain, younger age of onset, more side effects, higher doses of antipsychotics and were more likely to receive first-generation antipsychotics and less likely to receive benzodiazepines (total R-2=0.31, p<0.001).

Conclusions: APP was found in about one in three schizophrenia patients. The prevalence of APP seems to have been increasing since 2002. Considering the increased frequency of drug-induced side effects and the patients′ and their relatives′ dissatisfaction with antipsychotic treatment, further examination of the rationale and appropriateness of APP and its alternatives is warranted.

语种英语
WOS记录号WOS:000348645600007
项目编号2011ZX09302-004
资助机构12th Five-Year Plan of the National Key Technologies R&amp ; D Program of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63583
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
北京大学精神卫生研究所_药理室
作者单位1.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
3.Univ Macau, Fac Hlth Sci, Macau, Macao, Peoples R China
4.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
5.North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
6.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
7.Hosp Psychiat, Guangzhou, Guangdong, Peoples R China
8.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430072, Peoples R China
9.Shanxi Med Univ, Hosp 1, Taiyuan, Shanxi Province, Peoples R China
10.Sichuan Univ, West China Hosp, Chengdu, Peoples R China
11.Neuropsychiat Hosp, Changchun, Jilin, Peoples R China
12.Mental Hlth Ctr, Xian, Peoples R China
13.Jiangxi Psychiat Hosp, Nanchang, Jiangxi, Peoples R China
14.Suzhou Guangji Hosp, Suzhou, Peoples R China
15.Hebei Mental Hlth Ctr, Baoding, Hebei, Peoples R China
推荐引用方式
GB/T 7714
Li, Qian,Xiang, Yu-Tao,Su, Yun-Ai,et al. Antipsychotic polypharmacy in schizophrenia patients in China and its association with treatment satisfaction and quality of life: Findings of the third national survey on use of psychotropic medications in China[J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,2015,49(2):129-136.
APA Li, Qian.,Xiang, Yu-Tao.,Su, Yun-Ai.,Shu, Liang.,Yu, Xin.,...&Si, Tian-Mei.(2015).Antipsychotic polypharmacy in schizophrenia patients in China and its association with treatment satisfaction and quality of life: Findings of the third national survey on use of psychotropic medications in China.AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,49(2),129-136.
MLA Li, Qian,et al."Antipsychotic polypharmacy in schizophrenia patients in China and its association with treatment satisfaction and quality of life: Findings of the third national survey on use of psychotropic medications in China".AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY 49.2(2015):129-136.
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