|Methylation of p16 CpG islands correlated with metastasis and aggressiveness in papillary thyroid carcinoma|
|Wang, Peng1; Pei, Renguang2; Lu, Zheming3; Rao, Xiaosong4; Liu, Baoguo3,5|
|关键词||CpG islands methylation P16 papillary thyroid carcinoma|
|刊名||JOURNAL OF THE CHINESE MEDICAL ASSOCIATION|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||TUMOR-SUPPRESSOR GENE ; GASTRIC-CANCER ; LUNG-CANCER ; ABERRANT METHYLATION ; CHROMATIN-STRUCTURE ; CELL-LINES ; HYPERMETHYLATION ; P16(INK4A) ; CARCINOGENESIS ; EXPRESSION|
Background: Inactivation of p16 by methylation of CpG islands is a frequent early event in human cancers, including papillary thyroid carcinoma (PTC). This study was to observe the methylation status of the p16 gene in papillary thyroid carcinoma (PTC) and its correlation with clinical parameters.
Methods: Methylation-specific PCR (MSP) was used to analyze the methylation status of the p16 gene in 74 PTCs and 21 adjacent normal thyroid tissues.
Results: Hypermethylation of p16 gene was observed in 27.0% (20/74) of PTC. None of the normal thyroid tissues was methylated, when compared to the PTCs (p < 0.05). There was no marked relationship between the methylation of p16 gene and the patients′ age, gender, size of cancer, histological subtypes and occurrence of recurrent disease (p > 0.05). The methylation of p16 gene was positively associated with metastasis, a high AMES (age, metastasis to distant sites, extrathyroidal invasion, size) risk group (p < 0.05) and advanced pathological tumor lymph node-metastasis stages.
Conclusion: The methylation of the p16 gene, one event of significance in molecular biology, was common and correlated with biological metastasis and histological features in PTC, and may be involved in thyroid tumorigenesis and aggressiveness. Copyright (C) 2012 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.
|作者单位||1.Zhejiang Canc Hosp, Dept Head & Neck Surg, Hangzhou, Zhejiang, Peoples R China|
2.Wannan Med Coll, Yijishan Hosp, Dept Intervent & Radiol, Wuhu, Peoples R China
3.Peking Univ, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Etiol,Sch Oncol, Beijing 100142, Peoples R China
4.Peking Univ, Shougang Hosp, Dept Pathol, Beijing 100142, Peoples R China
5.Peking Univ, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Head & Neck Surg,Sch Oncol, Beijing 100142, Peoples R China
|Wang, Peng,Pei, Renguang,Lu, Zheming,et al. Methylation of p16 CpG islands correlated with metastasis and aggressiveness in papillary thyroid carcinoma[J]. JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,2013,76(3):135-139.|
|APA||Wang, Peng,Pei, Renguang,Lu, Zheming,Rao, Xiaosong,&Liu, Baoguo.(2013).Methylation of p16 CpG islands correlated with metastasis and aggressiveness in papillary thyroid carcinoma.JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,76(3),135-139.|
|MLA||Wang, Peng,et al."Methylation of p16 CpG islands correlated with metastasis and aggressiveness in papillary thyroid carcinoma".JOURNAL OF THE CHINESE MEDICAL ASSOCIATION 76.3(2013):135-139.|