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学科主题临床医学
Methylation of p16 CpG islands correlated with metastasis and aggressiveness in papillary thyroid carcinoma
Wang, Peng1; Pei, Renguang2; Lu, Zheming3; Rao, Xiaosong4; Liu, Baoguo3,5
关键词CpG islands methylation P16 papillary thyroid carcinoma
刊名JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
2013-03-01
DOI10.1016/j.jcma.2012.11.007
76期:3页:135-139
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]TUMOR-SUPPRESSOR GENE ; GASTRIC-CANCER ; LUNG-CANCER ; ABERRANT METHYLATION ; CHROMATIN-STRUCTURE ; CELL-LINES ; HYPERMETHYLATION ; P16(INK4A) ; CARCINOGENESIS ; EXPRESSION
英文摘要

Background: Inactivation of p16 by methylation of CpG islands is a frequent early event in human cancers, including papillary thyroid carcinoma (PTC). This study was to observe the methylation status of the p16 gene in papillary thyroid carcinoma (PTC) and its correlation with clinical parameters.

Methods: Methylation-specific PCR (MSP) was used to analyze the methylation status of the p16 gene in 74 PTCs and 21 adjacent normal thyroid tissues.

Results: Hypermethylation of p16 gene was observed in 27.0% (20/74) of PTC. None of the normal thyroid tissues was methylated, when compared to the PTCs (p < 0.05). There was no marked relationship between the methylation of p16 gene and the patients′ age, gender, size of cancer, histological subtypes and occurrence of recurrent disease (p > 0.05). The methylation of p16 gene was positively associated with metastasis, a high AMES (age, metastasis to distant sites, extrathyroidal invasion, size) risk group (p < 0.05) and advanced pathological tumor lymph node-metastasis stages.

Conclusion: The methylation of the p16 gene, one event of significance in molecular biology, was common and correlated with biological metastasis and histological features in PTC, and may be involved in thyroid tumorigenesis and aggressiveness. Copyright (C) 2012 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.

语种英语
WOS记录号WOS:000317945700004
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63592
专题北京大学首钢医院_病理科
北京大学临床肿瘤学院_头颈外科
北京大学临床肿瘤学院_病因学研究室
作者单位1.Zhejiang Canc Hosp, Dept Head & Neck Surg, Hangzhou, Zhejiang, Peoples R China
2.Wannan Med Coll, Yijishan Hosp, Dept Intervent & Radiol, Wuhu, Peoples R China
3.Peking Univ, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Etiol,Sch Oncol, Beijing 100142, Peoples R China
4.Peking Univ, Shougang Hosp, Dept Pathol, Beijing 100142, Peoples R China
5.Peking Univ, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Head & Neck Surg,Sch Oncol, Beijing 100142, Peoples R China
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Wang, Peng,Pei, Renguang,Lu, Zheming,et al. Methylation of p16 CpG islands correlated with metastasis and aggressiveness in papillary thyroid carcinoma[J]. JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,2013,76(3):135-139.
APA Wang, Peng,Pei, Renguang,Lu, Zheming,Rao, Xiaosong,&Liu, Baoguo.(2013).Methylation of p16 CpG islands correlated with metastasis and aggressiveness in papillary thyroid carcinoma.JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,76(3),135-139.
MLA Wang, Peng,et al."Methylation of p16 CpG islands correlated with metastasis and aggressiveness in papillary thyroid carcinoma".JOURNAL OF THE CHINESE MEDICAL ASSOCIATION 76.3(2013):135-139.
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