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IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科  > 期刊论文
学科主题: 临床医学
题名:
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma
作者: Lv, Liang1,2; Shen, Zhanlong1; Zhang, Jizhun1; Zhang, Hui1; Dong, Jianqiang3; Yan, Yichao1; Liu, Fangfang4; Jiang, Kewei1; Ye, Yingjiang1; Wang, Shan1
关键词: Carcinogenesis ; Colorectal cancer ; Immunohistochemistry ; Prognosis ; SIRT1
刊名: MEDICAL ONCOLOGY
发表日期: 2014-06-01
DOI: 10.1007/s12032-014-0965-9
卷: 31, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CANCER-CELLS ; DEACETYLASE ; SIRTUINS ; INFLAMMATION
英文摘要:

Sirtuin 1 (SIRT1) has been reported to have diverse roles in various biological processes through deacetylation of histone and nonhistone proteins. However, the correlations between SIRT1 protein expression, clinicopathological parameters, and survival of colorectal cancer patients remain unclear. SIRT1 protein expression in a paraffin-embedded tissue microarray, including 13 benign adenomas, nine liver metastasis tissues, and 120 paired colorectal cancer and normal mucosa tissues, was measured by immunohistochemistry. SIRT1 mRNA and protein expression in colon cancer cell lines with different metastatic potential and normal colon cells were detected by real-time reverse transcription polymerase chain reaction (RT-PCR) and Western blotting. The correlations between SIRT1 protein expression, clinicopathological features, and prognosis were analyzed. All samples (100 %) were positive for SIRT1, with variable staining in the cytoplasm rather than the nucleus. There was significant difference in SIRT1 overexpression between adenocarcinomas and normal mucosal tissues (P < 0.01, chi(2) test). SIRT1 overexpression was more frequently observed in advanced-stage tumors and lymph node or liver metastases (P = 0.046, 0.002, and 0.004, respectively, chi(2) test). SIRT1 expression was also significantly elevated in the more aggressive colon cancer cell line SW620. SIRT1 overexpression was significantly correlated with poor overall survival (P = 0.013, log-rank test) and disease-free survival (P = 0.012, log-rank test). SIRT1 overexpression was correlated with advanced-stage and poor prognosis. SIRT1 may play an important role in the progression of colorectal cancer.

语种: 英语
所属项目编号: 81372290 ; 81372291 ; 2107000074 ; RDB 2012-18 ; RDB 2013-15
项目资助者: National Science Foundation of China ; Beijing Municipal Science and Technology Project ; Peking University People&prime ; s Hospital Research and Development Funds
WOS记录号: WOS:000339003100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63596
Appears in Collections:北京大学第二临床医学院_胃肠外科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China
2.Qingdao Univ, Affiliated Hosp, Dept Gen Surg, Qingdao 266000, Shandong, Peoples R China
3.Peking Univ, Peoples Hosp, Cent Lab, Beijing 100044, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100044, Peoples R China

Recommended Citation:
Lv, Liang,Shen, Zhanlong,Zhang, Jizhun,et al. Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma[J]. MEDICAL ONCOLOGY,2014,31(6).
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