IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科
学科主题临床医学
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma
Lv, Liang1,2; Shen, Zhanlong1; Zhang, Jizhun1; Zhang, Hui1; Dong, Jianqiang3; Yan, Yichao1; Liu, Fangfang4; Jiang, Kewei1; Ye, Yingjiang1; Wang, Shan1
关键词Carcinogenesis Colorectal cancer Immunohistochemistry Prognosis SIRT1
刊名MEDICAL ONCOLOGY
2014-06-01
DOI10.1007/s12032-014-0965-9
31期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CANCER-CELLS ; DEACETYLASE ; SIRTUINS ; INFLAMMATION
英文摘要

Sirtuin 1 (SIRT1) has been reported to have diverse roles in various biological processes through deacetylation of histone and nonhistone proteins. However, the correlations between SIRT1 protein expression, clinicopathological parameters, and survival of colorectal cancer patients remain unclear. SIRT1 protein expression in a paraffin-embedded tissue microarray, including 13 benign adenomas, nine liver metastasis tissues, and 120 paired colorectal cancer and normal mucosa tissues, was measured by immunohistochemistry. SIRT1 mRNA and protein expression in colon cancer cell lines with different metastatic potential and normal colon cells were detected by real-time reverse transcription polymerase chain reaction (RT-PCR) and Western blotting. The correlations between SIRT1 protein expression, clinicopathological features, and prognosis were analyzed. All samples (100 %) were positive for SIRT1, with variable staining in the cytoplasm rather than the nucleus. There was significant difference in SIRT1 overexpression between adenocarcinomas and normal mucosal tissues (P < 0.01, chi(2) test). SIRT1 overexpression was more frequently observed in advanced-stage tumors and lymph node or liver metastases (P = 0.046, 0.002, and 0.004, respectively, chi(2) test). SIRT1 expression was also significantly elevated in the more aggressive colon cancer cell line SW620. SIRT1 overexpression was significantly correlated with poor overall survival (P = 0.013, log-rank test) and disease-free survival (P = 0.012, log-rank test). SIRT1 overexpression was correlated with advanced-stage and poor prognosis. SIRT1 may play an important role in the progression of colorectal cancer.

语种英语
WOS记录号WOS:000339003100003
项目编号81372290 ; 81372291 ; 2107000074 ; RDB 2012-18 ; RDB 2013-15
资助机构National Science Foundation of China ; Beijing Municipal Science and Technology Project ; Peking University People&prime ; s Hospital Research and Development Funds
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63596
专题北京大学第二临床医学院_胃肠外科
北京大学第二临床医学院_病理科
作者单位1.Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China
2.Qingdao Univ, Affiliated Hosp, Dept Gen Surg, Qingdao 266000, Shandong, Peoples R China
3.Peking Univ, Peoples Hosp, Cent Lab, Beijing 100044, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Lv, Liang,Shen, Zhanlong,Zhang, Jizhun,et al. Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma[J]. MEDICAL ONCOLOGY,2014,31(6).
APA Lv, Liang.,Shen, Zhanlong.,Zhang, Jizhun.,Zhang, Hui.,Dong, Jianqiang.,...&Wang, Shan.(2014).Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.MEDICAL ONCOLOGY,31(6).
MLA Lv, Liang,et al."Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma".MEDICAL ONCOLOGY 31.6(2014).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lv, Liang]的文章
[Shen, Zhanlong]的文章
[Zhang, Jizhun]的文章
百度学术
百度学术中相似的文章
[Lv, Liang]的文章
[Shen, Zhanlong]的文章
[Zhang, Jizhun]的文章
必应学术
必应学术中相似的文章
[Lv, Liang]的文章
[Shen, Zhanlong]的文章
[Zhang, Jizhun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。