IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Pharmacokinetic and pharmacodynamic effects of clonazepam in children with epilepsy treated with valproate: A preliminary study
Wang, L; Wang, XD
关键词quantitative pharmaco-EEG clonazepam pharmacokinetics pharmacodynamics epilepsy children
刊名THERAPEUTIC DRUG MONITORING
2002-08-01
24期:4页:532-536
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology ; Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Medical Laboratory Technology ; Pharmacology & Pharmacy ; Toxicology
英文摘要

The authors report the use of the quantitative pharmaco-EEG (QPEEG) technique to study the pharmacokinetics (PK) and pharmacodynamics (PD) of clonazepam (CZP) in four epileptic children who Suffered uncontrolled seizures despite long-term valproate (VPA) therapy. After a sin.-le dose of CZP (0.05 mg/kg PO). blood samples were collected at 0, 0.5, 1.0, 1.5, 2.0, 3.0, 4.0 8.0 12.0, and 24.0 hours. CZP and VPA concentrations were measured by HPLC or GC assay, respectively. At each blood collection time point, EEG signals (60 s) were recorded for brain electrical activity mapping, and the power percentage average (PPA) of each frequency band was calculated. The relationship between drug concentrations and their corresponding PPA of each frequency hand was analyzed. VPA steady-state drug concentrations (C-ss) were within the therapeutic range and not affected by CZP. The peak concentration (C-max) of CZP and the time intervals from dosing to C-max (T-max) were 20.9 ng/mL to 113.8 ng/mL and I hour to 1.5 hours, respectively. There was no significant correlation between VPA concentrations and the PPA of any of the EEG frequency hands. CZP blood concentrations showed significant correlation with PPA in 3 of the 4 patients. Our results suggested CZP Could affect fast wave activities in proportion to CZP blood concentrations. We propose that QPEEG is a promising technique to study the PK and PD of selected anti-epileptic drugs.

语种英语
WOS记录号WOS:000177060100012
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63597
专题北京大学第一临床医学院
作者单位Peking Univ, First Hosp, Beijing 100034, Peoples R China
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Wang, L,Wang, XD. Pharmacokinetic and pharmacodynamic effects of clonazepam in children with epilepsy treated with valproate: A preliminary study[J]. THERAPEUTIC DRUG MONITORING,2002,24(4):532-536.
APA Wang, L,&Wang, XD.(2002).Pharmacokinetic and pharmacodynamic effects of clonazepam in children with epilepsy treated with valproate: A preliminary study.THERAPEUTIC DRUG MONITORING,24(4),532-536.
MLA Wang, L,et al."Pharmacokinetic and pharmacodynamic effects of clonazepam in children with epilepsy treated with valproate: A preliminary study".THERAPEUTIC DRUG MONITORING 24.4(2002):532-536.
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