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学科主题: 临床医学
题名:
Pharmacokinetic and pharmacodynamic effects of clonazepam in children with epilepsy treated with valproate: A preliminary study
作者: Wang, L; Wang, XD
关键词: quantitative pharmaco-EEG ; clonazepam ; pharmacokinetics ; pharmacodynamics ; epilepsy ; children
刊名: THERAPEUTIC DRUG MONITORING
发表日期: 2002-08-01
卷: 24, 期:4, 页:532-536
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology ; Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Medical Laboratory Technology ; Pharmacology & Pharmacy ; Toxicology
英文摘要:

The authors report the use of the quantitative pharmaco-EEG (QPEEG) technique to study the pharmacokinetics (PK) and pharmacodynamics (PD) of clonazepam (CZP) in four epileptic children who Suffered uncontrolled seizures despite long-term valproate (VPA) therapy. After a sin.-le dose of CZP (0.05 mg/kg PO). blood samples were collected at 0, 0.5, 1.0, 1.5, 2.0, 3.0, 4.0 8.0 12.0, and 24.0 hours. CZP and VPA concentrations were measured by HPLC or GC assay, respectively. At each blood collection time point, EEG signals (60 s) were recorded for brain electrical activity mapping, and the power percentage average (PPA) of each frequency band was calculated. The relationship between drug concentrations and their corresponding PPA of each frequency hand was analyzed. VPA steady-state drug concentrations (C-ss) were within the therapeutic range and not affected by CZP. The peak concentration (C-max) of CZP and the time intervals from dosing to C-max (T-max) were 20.9 ng/mL to 113.8 ng/mL and I hour to 1.5 hours, respectively. There was no significant correlation between VPA concentrations and the PPA of any of the EEG frequency hands. CZP blood concentrations showed significant correlation with PPA in 3 of the 4 patients. Our results suggested CZP Could affect fast wave activities in proportion to CZP blood concentrations. We propose that QPEEG is a promising technique to study the PK and PD of selected anti-epileptic drugs.

语种: 英语
WOS记录号: WOS:000177060100012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63597
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, First Hosp, Beijing 100034, Peoples R China

Recommended Citation:
Wang, L,Wang, XD. Pharmacokinetic and pharmacodynamic effects of clonazepam in children with epilepsy treated with valproate: A preliminary study[J]. THERAPEUTIC DRUG MONITORING,2002,24(4):532-536.
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