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学科主题: 临床医学
题名:
Orally Administered Lactoferrin Preserves Bone Mass and Microarchitecture in Ovariectomized Rats
作者: Guo, Hui Yuan1,2; Jiang, Lu1,2; Ibrahim, Salam A.3; Zhang, Lian4; Zhang, Hao1,2; Zhang, Ming1,2; Ren, Fa Zheng1,2
刊名: JOURNAL OF NUTRITION
发表日期: 2009-05-01
DOI: 10.3945/jn.108.100586
卷: 139, 期:5, 页:958-964
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: BOVINE LACTOFERRIN ; INGESTED LACTOFERRIN ; IN-VIVO ; CELLS ; OSTEOPOROSIS ; PROTEIN ; IMMUNE ; MICE ; PROLIFERATION ; RESPONSES
英文摘要:

Lactoferrin (LF) is reported to stimulate osteoblast proliferation and inhibit osteoclast activity in bone cell culture. However, the effect of oral LF on bone in osteoporosis needs to be explored. Three-month-old female Sprague-Dawley rats (n = 70) were assigned to the following groups: sham-operated, ovariectomized (OVX) untreated, OVX + bovine serum albumin (BSA; 85 mg/kg body weight), OVX + LF (0.85 mg/kg, 8.5 mg/kg, and 85 mg/kg body weight), and OVX + 17 beta-estradiol (E-2; 10 mu g/kg body weight). After 3 mo of treatment, E-2 completely prevented the OVX-induced bone loss. OVX rats treated with LF were protected against the OVX-induced reduction of bone volume, trabecular number, and thickness, and the elevation of trabecular separation was prevented. LF also increased bone mineral density and increased the parameters of mechanical strength at 8.5- and 85-mg/kg doses. Greater bone formation and reduced bone resorption, as assessed by biochemical markers of bone remodeling, occurred in rats administered LF. LF at 8.5- and 85-mg/kg concentrations caused a significant decrease in serum calcium, but this reduction did not occur in rats fed 0.85 mg/kg LF. In addition, serum tumor necrosis factor-a and interleukin-6 production were suppressed and serum calcitonin was elevated significantly in LF-fed rats at all 3 doses. These findings indicated that oral LF not only preserved bone mass but also improved bone microarchitecture. The absorption of LF peptides and their effects on bone cells could to some extent account for the osteogenic function of oral LF. J. Nutr. 139: 958-964, 2009.

语种: 英语
所属项目编号: 2006BAD04A06
项目资助者: National Key Technologies R &amp ; D Program of China
WOS记录号: WOS:000265424500022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63599
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Minist Educ, Key Lab Funct Dairy, Beijing 100083, Peoples R China
2.Beijing Univ, Sch Oncol, Beijing 100036, Peoples R China
3.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
4.N Carolina Agr & Tech State Univ, Food Microbiol & Biotechnol Lab, Greensboro, NC 27411 USA

Recommended Citation:
Guo, Hui Yuan,Jiang, Lu,Ibrahim, Salam A.,et al. Orally Administered Lactoferrin Preserves Bone Mass and Microarchitecture in Ovariectomized Rats[J]. JOURNAL OF NUTRITION,2009,139(5):958-964.
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