IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Orally Administered Lactoferrin Preserves Bone Mass and Microarchitecture in Ovariectomized Rats
Guo, Hui Yuan1,2; Jiang, Lu1,2; Ibrahim, Salam A.3; Zhang, Lian4; Zhang, Hao1,2; Zhang, Ming1,2; Ren, Fa Zheng1,2
刊名JOURNAL OF NUTRITION
2009-05-01
DOI10.3945/jn.108.100586
139期:5页:958-964
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
资助者National Key Technologies R &amp ; D Program of China ; National Key Technologies R &amp ; D Program of China
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]BOVINE LACTOFERRIN ; INGESTED LACTOFERRIN ; IN-VIVO ; CELLS ; OSTEOPOROSIS ; PROTEIN ; IMMUNE ; MICE ; PROLIFERATION ; RESPONSES
英文摘要

Lactoferrin (LF) is reported to stimulate osteoblast proliferation and inhibit osteoclast activity in bone cell culture. However, the effect of oral LF on bone in osteoporosis needs to be explored. Three-month-old female Sprague-Dawley rats (n = 70) were assigned to the following groups: sham-operated, ovariectomized (OVX) untreated, OVX + bovine serum albumin (BSA; 85 mg/kg body weight), OVX + LF (0.85 mg/kg, 8.5 mg/kg, and 85 mg/kg body weight), and OVX + 17 beta-estradiol (E-2; 10 mu g/kg body weight). After 3 mo of treatment, E-2 completely prevented the OVX-induced bone loss. OVX rats treated with LF were protected against the OVX-induced reduction of bone volume, trabecular number, and thickness, and the elevation of trabecular separation was prevented. LF also increased bone mineral density and increased the parameters of mechanical strength at 8.5- and 85-mg/kg doses. Greater bone formation and reduced bone resorption, as assessed by biochemical markers of bone remodeling, occurred in rats administered LF. LF at 8.5- and 85-mg/kg concentrations caused a significant decrease in serum calcium, but this reduction did not occur in rats fed 0.85 mg/kg LF. In addition, serum tumor necrosis factor-a and interleukin-6 production were suppressed and serum calcitonin was elevated significantly in LF-fed rats at all 3 doses. These findings indicated that oral LF not only preserved bone mass but also improved bone microarchitecture. The absorption of LF peptides and their effects on bone cells could to some extent account for the osteogenic function of oral LF. J. Nutr. 139: 958-964, 2009.

语种英语
所属项目编号2006BAD04A06
资助者National Key Technologies R &amp ; D Program of China ; National Key Technologies R &amp ; D Program of China
WOS记录号WOS:000265424500022
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63599
专题北京大学临床肿瘤学院
作者单位1.Minist Educ, Key Lab Funct Dairy, Beijing 100083, Peoples R China
2.Beijing Univ, Sch Oncol, Beijing 100036, Peoples R China
3.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
4.N Carolina Agr & Tech State Univ, Food Microbiol & Biotechnol Lab, Greensboro, NC 27411 USA
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GB/T 7714
Guo, Hui Yuan,Jiang, Lu,Ibrahim, Salam A.,et al. Orally Administered Lactoferrin Preserves Bone Mass and Microarchitecture in Ovariectomized Rats[J]. JOURNAL OF NUTRITION,2009,139(5):958-964.
APA Guo, Hui Yuan.,Jiang, Lu.,Ibrahim, Salam A..,Zhang, Lian.,Zhang, Hao.,...&Ren, Fa Zheng.(2009).Orally Administered Lactoferrin Preserves Bone Mass and Microarchitecture in Ovariectomized Rats.JOURNAL OF NUTRITION,139(5),958-964.
MLA Guo, Hui Yuan,et al."Orally Administered Lactoferrin Preserves Bone Mass and Microarchitecture in Ovariectomized Rats".JOURNAL OF NUTRITION 139.5(2009):958-964.
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