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学科主题: 临床医学
题名:
Characterization of differentially expressed genes in ovarian cancer by cDNA microarrays
作者: Zhang, X.; Feng, J.; Cheng, Y.; Yao, Y.; Ye, X.; Fu, T.; Cheng, H.
关键词: cDNA microarray ; gene expression ; ovarian cancer
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
发表日期: 2005
卷: 15, 期:1, 页:50-57
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: MOLECULAR-CLONING ; COMPLEMENTARY-DNA ; CELL CARCINOMA ; CD9 ANTIGEN ; PATTERNS ; FAMILY ; PTTG
英文摘要:

The molecular events leading to the development and progression of ovarian carcinoma are not completely understood. We performed a large-scale survey for the identification of differentially expressed genes between ovarian carcinoma and normal ovarian tissue by using cDNA microarray analysis. We utilized 512 member human novel putative oncogene and tumor suppressor gene cDNA microarrays to study the differences in gene expression between ovarian carcinoma and normal ovarian tissues. Some differentially expressed genes have been further confirmed by immunohistochemical analysis. A total of 39 differentially expressed genes were identified, of which 16 and 23 were specifically expressed in ovarian cancer and normal ovarian tissue, respectively. The comparison of average signal of differentially expressed genes exhibited at least a twofold difference in expression. The differentially expressed genes may be related to the carcinogenesis and progression of the malignant growth. The use of cDNA microarrays allows simultaneous monitor of the expression of many genes, thereby it speeds up the identification of differentially expressed genes. It is essential for further exploration of the mechanisms of the disease.

语种: 英语
WOS记录号: WOS:000226514700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63600
Appears in Collections:北京大学第二临床医学院_妇科肿瘤中心_期刊论文

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作者单位: Peking Univ Peoples Hosp, Gynecol Oncol Ctr, Beijing 100044, Peoples R China

Recommended Citation:
Zhang, X.,Feng, J.,Cheng, Y.,et al. Characterization of differentially expressed genes in ovarian cancer by cDNA microarrays[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2005,15(1):50-57.
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