IR@PKUHSC  > 北京大学第二临床医学院  > 妇科肿瘤中心
学科主题临床医学
Characterization of differentially expressed genes in ovarian cancer by cDNA microarrays
Zhang, X.; Feng, J.; Cheng, Y.; Yao, Y.; Ye, X.; Fu, T.; Cheng, H.
关键词cDNA microarray gene expression ovarian cancer
刊名INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
2005
15期:1页:50-57
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Obstetrics & Gynecology
研究领域[WOS]Oncology ; Obstetrics & Gynecology
关键词[WOS]MOLECULAR-CLONING ; COMPLEMENTARY-DNA ; CELL CARCINOMA ; CD9 ANTIGEN ; PATTERNS ; FAMILY ; PTTG
英文摘要

The molecular events leading to the development and progression of ovarian carcinoma are not completely understood. We performed a large-scale survey for the identification of differentially expressed genes between ovarian carcinoma and normal ovarian tissue by using cDNA microarray analysis. We utilized 512 member human novel putative oncogene and tumor suppressor gene cDNA microarrays to study the differences in gene expression between ovarian carcinoma and normal ovarian tissues. Some differentially expressed genes have been further confirmed by immunohistochemical analysis. A total of 39 differentially expressed genes were identified, of which 16 and 23 were specifically expressed in ovarian cancer and normal ovarian tissue, respectively. The comparison of average signal of differentially expressed genes exhibited at least a twofold difference in expression. The differentially expressed genes may be related to the carcinogenesis and progression of the malignant growth. The use of cDNA microarrays allows simultaneous monitor of the expression of many genes, thereby it speeds up the identification of differentially expressed genes. It is essential for further exploration of the mechanisms of the disease.

语种英语
WOS记录号WOS:000226514700009
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63600
专题北京大学第二临床医学院_妇科肿瘤中心
作者单位Peking Univ Peoples Hosp, Gynecol Oncol Ctr, Beijing 100044, Peoples R China
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GB/T 7714
Zhang, X.,Feng, J.,Cheng, Y.,et al. Characterization of differentially expressed genes in ovarian cancer by cDNA microarrays[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2005,15(1):50-57.
APA Zhang, X..,Feng, J..,Cheng, Y..,Yao, Y..,Ye, X..,...&Cheng, H..(2005).Characterization of differentially expressed genes in ovarian cancer by cDNA microarrays.INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,15(1),50-57.
MLA Zhang, X.,et al."Characterization of differentially expressed genes in ovarian cancer by cDNA microarrays".INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 15.1(2005):50-57.
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