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学科主题: 临床医学
题名:
Serum immunoglobulins in psoriatic erythroderma
作者: Li, LF; Sujan, SA; Yang, H; Wang, WH
刊名: CLINICAL AND EXPERIMENTAL DERMATOLOGY
发表日期: 2005-03-01
DOI: 10.1111/j.1365-2230.2004.01717.x
卷: 30, 期:2, 页:125-127
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: HYPER-IGE ; TH2 RESPONSES ; IFN-GAMMA ; DERMATITIS ; EOSINOPHILS ; INFECTION ; IL-4
英文摘要:

The cause of psoriatic erythroderma (PE) is still unknown. Elevation of serum IgE has been reported in erythroderma, and as serum hyper-IgE is Th2 cell dominated it is of interest to investigate the serum IgE level in PE. In this study, the level of immunoglobulins in the sera of PE patients was analysed by a retrospective case-control study using psoriasis vulgaris (PV) patients as controls. The PE and PV patients were matched in a 1 : 3 pattern: the first three age and sex matched PV inpatients were selected. All of the subjects were nonatopic and without allergic history. The serum IgE level was found to be elevated in 81.3% of the PE group, which is much higher than that (6.3%) of the controls (odds ratio, 65.0; 95% CI, 11.7-361.2; P < 0.001; chi(2) test). The mean level of serum IgE was much higher in the PE group (272.38 +/- 207.63 IU/mL vs. 53.20 +/- 86.05 IU/mL, P < 0.001, Student′s t-test). No differences were found for other immunoglobulins. These results suggest that in PE the Th1/Th2 cell imbalance may be switched from Th1 dominant to Th2 dominant. The exact role of serum IgE in PE should be investigated further.

语种: 英语
WOS记录号: WOS:000227193300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63601
Appears in Collections:北京大学第三临床医学院_皮肤科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Dermatol, Beijing 100871, Peoples R China

Recommended Citation:
Li, LF,Sujan, SA,Yang, H,et al. Serum immunoglobulins in psoriatic erythroderma[J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY,2005,30(2):125-127.
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