IR@PKUHSC  > 北京大学第三临床医学院  > 皮肤科
学科主题临床医学
Serum immunoglobulins in psoriatic erythroderma
Li, LF; Sujan, SA; Yang, H; Wang, WH
刊名CLINICAL AND EXPERIMENTAL DERMATOLOGY
2005-03-01
DOI10.1111/j.1365-2230.2004.01717.x
30期:2页:125-127
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
关键词[WOS]HYPER-IGE ; TH2 RESPONSES ; IFN-GAMMA ; DERMATITIS ; EOSINOPHILS ; INFECTION ; IL-4
英文摘要

The cause of psoriatic erythroderma (PE) is still unknown. Elevation of serum IgE has been reported in erythroderma, and as serum hyper-IgE is Th2 cell dominated it is of interest to investigate the serum IgE level in PE. In this study, the level of immunoglobulins in the sera of PE patients was analysed by a retrospective case-control study using psoriasis vulgaris (PV) patients as controls. The PE and PV patients were matched in a 1 : 3 pattern: the first three age and sex matched PV inpatients were selected. All of the subjects were nonatopic and without allergic history. The serum IgE level was found to be elevated in 81.3% of the PE group, which is much higher than that (6.3%) of the controls (odds ratio, 65.0; 95% CI, 11.7-361.2; P < 0.001; chi(2) test). The mean level of serum IgE was much higher in the PE group (272.38 +/- 207.63 IU/mL vs. 53.20 +/- 86.05 IU/mL, P < 0.001, Student′s t-test). No differences were found for other immunoglobulins. These results suggest that in PE the Th1/Th2 cell imbalance may be switched from Th1 dominant to Th2 dominant. The exact role of serum IgE in PE should be investigated further.

语种英语
WOS记录号WOS:000227193300004
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63601
Collection北京大学第三临床医学院_皮肤科
作者单位Peking Univ, Hosp 3, Dept Dermatol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Li, LF,Sujan, SA,Yang, H,et al. Serum immunoglobulins in psoriatic erythroderma[J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY,2005,30(2):125-127.
APA Li, LF,Sujan, SA,Yang, H,&Wang, WH.(2005).Serum immunoglobulins in psoriatic erythroderma.CLINICAL AND EXPERIMENTAL DERMATOLOGY,30(2),125-127.
MLA Li, LF,et al."Serum immunoglobulins in psoriatic erythroderma".CLINICAL AND EXPERIMENTAL DERMATOLOGY 30.2(2005):125-127.
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