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Biased genotype distributions of Candida albicans strains associated with vulvovaginal candidosis and candidal balanoposthitis in China
Li, Juan1; Fan, Shang-Rong7; Liu, Xiao-Ping7; Li, Dong-Ming2; Nie, Zhen-Hua10; Li, Fang3; Lin, Hua4; Huang, Wen-Ming8; Zong, Li-Li9; Jin, Jian-Gang5; Lei, Hong6; Bai, Feng-Yan1
刊名CLINICAL INFECTIOUS DISEASES
2008-11-01
DOI10.1086/592249
47期:9页:1119-1125
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Immunology ; Infectious Diseases ; Microbiology
研究领域[WOS]Immunology ; Infectious Diseases ; Microbiology
关键词[WOS]CLINICAL-MANIFESTATIONS ; INTESTINAL RESERVOIR ; VAGINITIS ; WOMEN ; MICROSATELLITE ; YEAST ; IDENTIFICATION ; EPIDEMIOLOGY ; TRANSMISSION ; PATHOGENESIS
英文摘要

Background. Vulvovaginal candidosis ( VVC), which is most frequently caused by Candida albicans, is one of the most common vaginal infections and is a common problem worldwide. Despite the fact that extensive epidemiological studies have been performed, what triggers VVC, especially recurrence of the infection, is still uncertain.

Methods. Genotypes of C. albicans strains associated with VVC and balanoposthitis and of strains isolated from samples from vaginas of asymptomatic women and from various extragenital sites were determined with use of C. albicans microsatellite locus I polymorphism analysis. Genetic similarity of representative strains with the same and different C. albicans microsatellite locus I genotypes were examined by sequence analysis of housekeeping genes CaADP1, CaSYA1, and CaVPS13.

Results. The C. albicans microsatellite locus I genotypes of independent C. albicans strains isolated from samples from extragenital sites were mostly of individual specificity. In contrast, strains associated with VVC were mainly concentrated to a few genotypes, with genotypes 30-45 and 32-46 being the most common. The overall frequencies of the 2 genotypes among C. albicans strains from vaginal samples from patients with VVC and from asymptomatic women were 59.1% and 24.0%, respectively (P = .002); the frequencies among patients with complicated VVC and among patients with uncomplicated VVC were 69.2% and 35.7%, respectively (P = .003). A similar genotype distribution pattern of C. albicans strains associated with balanoposthitis was also revealed. The genetic similarity of strains with the dominant genotypes associated with both VVC and balanoposthitis was confirmed by sequence analysis of the 3 genes.

Conclusions. The results suggest the existence of vaginopathic C. albicans strains with enhanced virulence and tropism for the vagina and the high possibility of sexual transmission of genital C. albicans infection. Identification of specific genotypes that correlate with severity of VVC is also of diagnostic and therapeutic significance.

语种英语
WOS记录号WOS:000259759100001
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63609
专题北京大学第三临床医学院_皮肤科
北京大学临床肿瘤学院_肿瘤放疗科
作者单位1.Chinese Acad Sci, Inst Microbiol, Systemat Mycol & Lichenol Lab, Beijing 100101, Peoples R China
2.Peking Univ, Hosp 3, Dept Dermatol, Beijing 100871, Peoples R China
3.Chaoyang Hosp, Dept Infect Dis & Clin Microbiol, Beijing, Peoples R China
4.China Japan Friendship Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
5.Peoples Liberat Army Gen Hosp, Affiliated Hosp 2, Dept Hematol, Beijing, Peoples R China
6.Peoples Liberat Army Gen Hosp, Affiliated Hosp 2, Dept Clin Lab, Beijing, Peoples R China
7.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen, Peoples R China
8.Guangdong Med Coll, Affiliated Hosp, Dept Dermatol, Zanjiang, Peoples R China
9.Nanfang Med Univ, Zhujiang Hosp, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China
10.Changzheng Hosp, Dept Dermatol & Venerol, Tianjin, Peoples R China
推荐引用方式
GB/T 7714
Li, Juan,Fan, Shang-Rong,Liu, Xiao-Ping,et al. Biased genotype distributions of Candida albicans strains associated with vulvovaginal candidosis and candidal balanoposthitis in China[J]. CLINICAL INFECTIOUS DISEASES,2008,47(9):1119-1125.
APA Li, Juan.,Fan, Shang-Rong.,Liu, Xiao-Ping.,Li, Dong-Ming.,Nie, Zhen-Hua.,...&Bai, Feng-Yan.(2008).Biased genotype distributions of Candida albicans strains associated with vulvovaginal candidosis and candidal balanoposthitis in China.CLINICAL INFECTIOUS DISEASES,47(9),1119-1125.
MLA Li, Juan,et al."Biased genotype distributions of Candida albicans strains associated with vulvovaginal candidosis and candidal balanoposthitis in China".CLINICAL INFECTIOUS DISEASES 47.9(2008):1119-1125.
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