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学科主题: 基础医学
题名:
Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma
作者: Xiang, Y; Ma, B; Li, T; Yu, HM; Li, XJ
关键词: acetazolamide ; neoplasm metastasis ; aquaporins ; actin
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2002-08-01
卷: 23, 期:8, 页:745-751
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CARBONIC-ANHYDRASE INHIBITOR ; AQUAPORIN 1 ; CELLS
英文摘要:

AIM: To study the suppressing effect of acetazolamide on tumor metastasis in vivo and observe the protein alteration of lung in mice bearing Lewis lung carcinoma. METHODS: The functional role of aquaporin-1 (AQP(1)) was investigated in tumor tissues by SDS-PAGE and Western blot. The effect of acetazolamide on tumor metastasis was analyzed by Lewis-lung-carcinoma model. Differential protein was identified by SDS-PAGE, isoelectrofocusing (IEF) methods, and peptide mass fingerprinting (PMF). RESULTS: Acetazolamide (40 mg(.)kg(-1.)d(-1)po for 21 d) dramatically reduced the numbers of lung metastasis after sc inoculating Lewis lung carcinoma. The inhibition rate of lung metastases was 83.9 %. Simultaneously, the AQP(1) protein level and actin-cytoplasmic in lungs containing metastatic tumor deposits were found to be higher than that in the normal tissue. After treated with acetazolamide for 21 d, the expression of AQP(1) was obviously inhibited. CONCLUSION: Acetazolamide can suppress tumor metastasis, at least in part, by inhibiting the expression of AQP(1). AQP(1) and actin-cytoplasmic may be new prognostic molecules as well as new therapeutic targets for the prevention and treatment of metastatic tumor.

语种: 英语
WOS记录号: WOS:000177314800012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63614
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Natl Res Inst Family Planning, Beijing 100081, Peoples R China

Recommended Citation:
Xiang, Y,Ma, B,Li, T,et al. Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma[J]. ACTA PHARMACOLOGICA SINICA,2002,23(8):745-751.
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