IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma
Xiang, Y; Ma, B; Li, T; Yu, HM; Li, XJ
关键词acetazolamide neoplasm metastasis aquaporins actin
刊名ACTA PHARMACOLOGICA SINICA
2002-08-01
23期:8页:745-751
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CARBONIC-ANHYDRASE INHIBITOR ; AQUAPORIN 1 ; CELLS
英文摘要

AIM: To study the suppressing effect of acetazolamide on tumor metastasis in vivo and observe the protein alteration of lung in mice bearing Lewis lung carcinoma. METHODS: The functional role of aquaporin-1 (AQP(1)) was investigated in tumor tissues by SDS-PAGE and Western blot. The effect of acetazolamide on tumor metastasis was analyzed by Lewis-lung-carcinoma model. Differential protein was identified by SDS-PAGE, isoelectrofocusing (IEF) methods, and peptide mass fingerprinting (PMF). RESULTS: Acetazolamide (40 mg(.)kg(-1.)d(-1)po for 21 d) dramatically reduced the numbers of lung metastasis after sc inoculating Lewis lung carcinoma. The inhibition rate of lung metastases was 83.9 %. Simultaneously, the AQP(1) protein level and actin-cytoplasmic in lungs containing metastatic tumor deposits were found to be higher than that in the normal tissue. After treated with acetazolamide for 21 d, the expression of AQP(1) was obviously inhibited. CONCLUSION: Acetazolamide can suppress tumor metastasis, at least in part, by inhibiting the expression of AQP(1). AQP(1) and actin-cytoplasmic may be new prognostic molecules as well as new therapeutic targets for the prevention and treatment of metastatic tumor.

语种英语
WOS记录号WOS:000177314800012
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63614
Collection北京大学基础医学院_药理学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Natl Res Inst Family Planning, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Xiang, Y,Ma, B,Li, T,et al. Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma[J]. ACTA PHARMACOLOGICA SINICA,2002,23(8):745-751.
APA Xiang, Y,Ma, B,Li, T,Yu, HM,&Li, XJ.(2002).Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma.ACTA PHARMACOLOGICA SINICA,23(8),745-751.
MLA Xiang, Y,et al."Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma".ACTA PHARMACOLOGICA SINICA 23.8(2002):745-751.
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